Association between occupational exposure of laboratory technicians to ionizing radiation and impact on blood biomarkers

Radiation Physics and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 112713 - 112713

Published: March 1, 2025

Language: Английский

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Knowledge and practice of radiation safety among radiographers in the radiology department in Pune, India

The Egyptian Journal of Radiology and Nuclear Medicine, Journal Year: 2025, Volume and Issue: 56(1)

Published: March 29, 2025

Abstract Background Knowledge of radiation safety and practices among radiographers working in the radiology department a tertiary care hospital is crucial for ensuring patient staff safety. This research aims to evaluate radiographers' understanding adherence protocols, thereby identifying areas improvement promoting culture within department. prospective cross-sectional survey 90 participants assesses knowledge Pune's departments. A convenience sampling technique was used as professionals were at hospitals Pune. Data collection via Google Form questionnaire ensures confidentiality informed consent. SPSS software analyze data. Pearson correlation analysis compare relationships between variables. Results Out total participants, 65 male 25 female, showing an overall 55.71% level knowledge. There statistical significance score by year experience qualification. According years experience, zero four high whereas taking academic qualification, diploma graduates inadequate. Conclusions Our study reveals that collective all average. Participants with 0–4 demonstrated higher levels, indicating both novices veterans radiography profession could benefit from enhanced understanding. Development tailored continuous education modules emphasizing protocols experienced gaps needed.

Language: Английский

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Effects of Ionizing Radiation on the Biophysical Properties of Type I Collagen Fibrils

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319777 - e0319777

Published: April 2, 2025

Ionizing radiation is extensively employed in both diagnostic and therapeutic medical practices. The impact of this on collagen, a primary structural protein humans, remains underexplored, particularly at varying doses hydration states. This study explores the ionizing type I collagen fibrils three (diagnostic, therapeutic, sterilization) under two conditions using an engineered acellular membrane to reflect biological conditions. Techniques including atomic force microscopy (AFM), fluorescence lifetime imaging (FLIM), Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) were utilized assess changes mechanical properties, biochemical stability, molecular structure respectively. Our results demonstrate that alters properties fibrils, notably indentation modulus, which reflects stiffness or elasticity. These modifications depended state time exposure; hydrated typically exhibited increased stiffness, suggesting enhanced cross-linking, whereas dehydrated showed reduced indicative weakening, possibly due bond breakdown. Morphological minimal, primarily affects internal rather than overall appearance fibrils. Biochemically, variations lifetimes highlighted collagen’s environment, dependent dose state. Despite these changes, FTIR analysis indicated was largely preserved post-irradiation for all examined levels. findings imply can modify potentially affecting tissue integrity clinical settings. could influence management radiation-induced like osteoradionecrosis, fibrosis cancer metastasis. Overall, our underscores need further research into effects proteins better understand mitigate damage.

Language: Английский

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Precise Electromagnetic Modulation of the Cell Cycle and Its Applications in Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4445 - 4445

Published: May 7, 2025

Precise modulation of the cell cycle via electromagnetic (EM) control presents a groundbreaking approach for cancer therapy, especially in development personalized treatment strategies. EM fields can precisely regulate key cellular homeostatic mechanisms such as proliferation, apoptosis, and repair by finely tuning parameters like frequency, intensity, duration. This review summarizes through which influence dynamics, highlighting recent developments high-throughput platforms that facilitate precise regulation. Additionally, integration with emerging technologies artificial intelligence, immunotherapy, nanotechnology is explored, collectively enhancing targeting precision, immune activation, therapeutic efficacy. A systematic analysis existing clinical studies indicates technology significantly overcomes challenges tumor heterogeneity, microenvironment complexity, treatment-related adverse effects. prospects translation future research directions, emphasizing its critical potential core element individualized multimodal

Language: Английский

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Effect of gamma irradiation on structural, morphological, optical and thermal properties of Ca doped CuO nanostructure thin films

Radiation effects and defects in solids, Journal Year: 2023, Volume and Issue: 178(3-4), P. 521 - 538

Published: Jan. 16, 2023

Semiconductor optoelectronic and photonic devices are used in many harsh environment applications such as space nuclear reactor etc. Gamma radiation environments significantly interacts with the semiconductor materials these devices, changing their structural, optical, morphological thermal properties. Therefore, it is vital to investigate gamma effect of material be exposed terms performance lifetime application. In this study, nanostructured thin films were produced by doping different ratios (0, 0.3, 1.25, 2.5 5 mg/mL) Ca copper oxide (CuO) a devices. The deposited on glass substrate spin coating method. effects rays morphological, optical properties investigated irradiating doses (1, 5, 15, 50, 100 150 kGy) Cobalt-60 source. doped CuO using X-ray diffractometer (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), atomic force microscope (AFM), mechanical profilometer, UV-Vis spectrophotometry (UV-Vis) thermogravimetric differential analyzer (TG/DTA). band gap been calculated Tauc’s plot. obtained results showed that high-dose caused defects undoped affected Despite resulting defects, higher absorption intensity stability against rays. These suitable for reactors.

Language: Английский

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A comprehensive analysis of the challenges and potential side effects of radiation therapy for palliative cancer treatment

Médecine Palliative, Journal Year: 2024, Volume and Issue: 23(2), P. 75 - 91

Published: Jan. 30, 2024

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Neuroprotective Action of Selected Natural Drugs Against Neurological Diseases and Mental Disorders: Potential Use Against Radiation Damage

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(9), P. 2336 - 2351

Published: June 12, 2024

Language: Английский

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The influence of apigenin on cellular responses to radiation: From protection to sensitization

BioFactors, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Apigenin, a dietary flavonoid, has gained increasing attention for its potential therapeutic applications in radiation protection and radiosensitization. Ionizing (IR) can harm healthy cells, but as radiotherapy remains crucial cancer treatment. Owing to the remarkable application of treatment cancers, it is vital protect cells from hazards while sensitivity radiation. This article reviews current understanding apigenin's radioprotective radiosensitive properties with focuses on involved signaling pathways key molecular targets. When exposed irradiation, apigenin reduces inflammation via cyclooxygenase‐2 inhibition modulates proapoptotic antiapoptotic biomarkers. Apigenin's radical scavenging abilities antioxidant enhancement mitigate oxidative DNA damage. It inhibits radiation‐induced mammalian target rapamycin activation, vascular endothelial growth factor (VEGF), matrix metalloproteinase‐2 (MMP), STAT3 expression, promoting AMPK, autophagy, apoptosis, suggesting prevention. As radiosensitizer, tumor by inducing suppressing VEGF‐C, necrosis alpha, STAT3, reducing MMP‐2/9 activity, inhibiting cell glucose uptake. Cellular animal studies support anticancer potential, making candidate further research. Investigation into efficacy diverse types damage essential.

Language: Английский

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Human DNA Mutations and their Impact on Genetic Disorders

Recent Patents on Biotechnology, Journal Year: 2023, Volume and Issue: 18(4), P. 288 - 315

Published: Nov. 8, 2023

Abstract: DNA is a remarkably precise medium for copying and storing biological information. It serves as design cellular machinery that permits cells, organs, even whole organisms to work. The fidelity of replication results from the action hundreds genes involved in proofreading damage repair. All human cells can acquire genetic changes their all over life. Genetic mutations are sequence happen during cell division when make copies themselves. Mutations cause illnesses such cancer, or they could help humans better adapt environment time. endogenous reactive metabolites, therapeutic medicines, an excess environmental mutagens, UV rays continuously DNA, compromising its integrity. One more chromosomal alterations point at single site (monogenic mutation) including deletions, duplications, inversions illustrate mutations. conditions occur altered gene inherited parents, which increases risk developing particular condition, some randomly. Moreover, symptoms depend on has mutation. There many different diseases caused by Some most common Alzheimer’s disease, cancers, cystic fibrosis, Down syndrome, sickle disease. Interestingly, scientists find than formerly thought. This review outlines main along genome influence health. subject patents pertaining disorders been brought up.

Language: Английский

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Transition Metal Borides for All-in-One Radiation Shielding

Materials, Journal Year: 2023, Volume and Issue: 16(19), P. 6496 - 6496

Published: Sept. 29, 2023

All-in-one radiation shielding is an emerging concept in developing new-generation protection materials since various forms of ionizing radiation, such as neutrons and gamma rays, can occur simultaneously. In this study, we examine the ability transition metal borides to attenuate both photon particle radiation. Specifically, fourteen different (including inner borides) are selected for examination based on their thermodynamic stabilities, molecular weights, neutron capture cross-sections elements they contain. Radiation characteristics computationally investigated using Phy-X/PSD, EpiXS NGCal software. The gamma-ray capabilities evaluated terms mass attenuation coefficient (μm), linear (µ), effective atomic number (Zeff), half-value layer (HVL), tenth-value (TVL), mean free path (MFP). factors identified thermal fast at energies 0.025 eV 4 MeV, respectively. Moreover, removal (∑R) calculated assess abilities. results revealed that metals with a high number, Re, W, Ta, possess outstanding performance. At MeV energy, layers ReB2 WB2 compounds were found 1.38 cm 1.43 cm, Most notably, these HVL values lower than value toxic Pb (1.45 MeV), which one conventional materials. On other hand, SmB6 DyB6 demonstrated exceptional due Sm, Dy, B. outcomes study reveal be suitable candidates against mixed

Language: Английский

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