Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
98(4), P. 1181 - 1197
Published: March 26, 2024
Evidence
in
the
literature
indicates
that
aerobic
physical
activity
may
have
a
protective
role
aging
pathologies.
However,
it
has
not
been
clarified
whether
different
types
of
exercise
produce
effects.
In
particular,
these
potential
differences
explored
patients
with
Alzheimer’s
disease
(AD).
The
present
narrative
review
specific
aim
evaluating
land
(walking/running)
and
water
(swimming)
activities
exert
effects
on
cognitive
functions
neural
correlates
AD
patients.
investigation
is
carried
out
by
comparing
evidence
provided
from
studies
animal
models
On
whole,
we
ascertained
both
human
documented
beneficial
cognition
AD.
Also,
modulation
numerous
biological
processes
association
structural
modifications.
Remarkably,
found
appears
to
improve
per
se,
independently
kind
performed.
Aerobic
promotes
brain
functioning
through
secretion
molecular
factors
skeletal
muscles
liver.
These
stimulate
neuroplasticity,
reduce
neuroinflammation,
inhibit
neurodegenerative
leading
amyloid-β
accumulation.
Additionally,
improves
mitochondrial
activity,
reducing
oxidative
stress
enhancing
ATP
production.
protect
against
AD,
but
implementing
protocols
for
challenging.
We
suggest
health
policies
specialized
institutions
should
direct
increasing
attention
as
lifestyle
modifiable
factor
successful
age-related
conditions.
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 10, 2023
Introduction
Cognitive
decline
is
a
central
manifestation
of
Alzheimer's
disease
(AD),
and
its
process
inseparable
from
changes
in
synaptic
plasticity.
The
aim
this
review
was
to
summarize
evaluate
the
effectiveness
exercise
on
cognitive
function
plasticity
AD
animal
models.
Materials
methods
Eligible
studies
were
searched
PubMed,
MEDLINE,
EMBASE,
Web
Science,
Cochrane
Library
April
May
2022.
risk
bias
evaluated
by
Systematic
Review
Centre
for
Laboratory
Animal
Experimentation
(SYRCLE).
Morris
water
maze
(MWM)
test
considered
outcome
measures.
Data
analyzed
using
random-effects
meta-analyses
software
Stata.
Heterogeneity
examined
I2
test.
Sensitivity
analysis
publication
also
assessed.
Results
A
total
20
randomized
controlled
eligible
study
inclusion.
Compared
with
controls,
decreased
escape
latency
(SMD
=
−0.86,
95%
CI:
−1.21
−0.50,
P
<
0.001),
increased
platform
crossover
numbers
1.34,
0.57–2.11,
0.001)
time
target
quadrant
1.65,
0.95–2.36,
expression
PSD95
0.73,
0.25–1.21,
0.003)
animals.
results
subgroup
showed
that
before
had
greater
effect
−0.88,
−1.25
−0.52,
1.71,
1.23–2.18,
2.03,
1.19–2.87,
0.94,
0.19–1.69,
0.014)
than
after
AD.
treadmill
running
might
be
an
appropriate
type.
Conclusion
Our
findings
suggested
potential
improving
It
can
play
better
neuroprotective
role
registration
PROSPERO,
identifier:
CRD42022328438.
