Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: June 8, 2023
Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical
Language: Английский
Citations
474
Human Reproduction Update, Journal Year: 2023, Volume and Issue: 29(6), P. 773 - 793
Published: July 19, 2023
Abstract BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced is one of critical risk factors for female-related infertility. It well known that maternal positively correlates with deterioration oocyte quality and chromosomal abnormalities oocytes embryos. The effect on endometrial function may be equally important factor influencing implantation rate, pregnancy overall female fertility. However, there are only a few published studies this topic, suggesting area been under-explored. Improving our knowledge aging from biological (cellular, molecular, histological) clinical perspectives would broaden understanding risks age-related OBJECTIVE AND RATIONALE objective narrative review critically evaluate existing literature focus synthesizing evidence impact conception success. This provide insights into gaps application research findings promote development treatment options field. SEARCH METHODS was prepared using PubMed (Medline) until February 2023 keywords such as ‘endometrial aging’, ‘receptivity’, ‘decidualization’, ‘hormone’, ‘senescence’, ‘cellular’, ‘molecular’, ‘methylation’, ‘biological age’, ‘epigenetic’, ‘oocyte recipient’, donation’, ‘embryo transfer’, ‘pregnancy rate’. Articles language other than English were excluded. OUTCOMES In endometrium, alterations occur cellular, histological levels negative biology impair receptivity. Additionally, advanced influences cellular senescence, which plays role during initial phase major obstacle suitable senolytic agents aging. Aging also accountable chronic conditions associated inflammaging, eventually can lead increased pro-inflammation tissue fibrosis. Furthermore, epigenetic regulation thus altering relation between its chronological age. donation cycles determine receptivity respect rates implantation, pregnancy, miscarriage, live birth have revealed contradictory inferences indicating need future mechanisms corresponding causal effects women’s WIDER IMPLICATIONS Increasing infertility IVF failures. Based complied observations synthesized conclusions review, shown functioning. information recommendations focusing molecular composition, transcriptomic changes further prospective needed explore newly emerging therapeutic options, target without affecting decidualization. Moreover, trial protocols, cycles, beneficial direct implications outcomes.
Language: Английский
Citations
52
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: May 24, 2023
Knowledge of aging biology needs to be expanded due the continuously growing number elderly people worldwide. Aging induces changes that affect all systems body. The risk cardiovascular disease and cancer increases with age. In particular, age-induced adaptation immune system causes a greater susceptibility infections contributes inability control pathogen growth immune-mediated tissue damage. Since impact on function, is still fully elucidated, this review addresses some recent understanding age-related affecting key components immunity. emphasis immunosenescence inflammaging are impacted by common infectious diseases characterized high mortality, includes COVID-19, HIV tuberculosis.
Language: Английский
Citations
50
Cell, Journal Year: 2024, Volume and Issue: 187(15), P. 4030 - 4042.e13
Published: June 21, 2024
Language: Английский
Citations
23
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 87, P. 101909 - 101909
Published: March 12, 2023
Spaceflight and its associated stressors, such as microgravity, radiation exposure, confinement, circadian derailment disruptive workloads represent an unprecedented type of exposome that is entirely novel from evolutionary stand point. Within this perspective, we aimed to review the effects prolonged spaceflight on immune-neuroendocrine systems, brain brain-gut axis, cardiovascular system musculoskeletal apparatus, highlighting in particular similarities with accelerated aging process. In particular, spaceflight-induced muscle atrophy/sarcopenia bone loss, vascular metabolic changes, hyper hypo reaction innate adaptive immune appear be modifications shared Most these are mediated by molecular events include oxidative mitochondrial stress, autophagy, DNA damage repair telomere length alteration, among others, which directly or indirectly converge activation inflammatory response. According inflammaging theory aging, response could a driver acceleration normal, physiological rate it likely all systemic turn lead increase sort vicious cycle. The most updated countermeasures fight will also discussed light their possible application not only for astronauts' benefit, but older adults ground.
Language: Английский
Citations
40
International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(10), P. 5845 - 5845
Published: May 17, 2023
The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have thoroughly examined, and with them, their function role individual's systems. microbiota's taxonomical dramatically impacts older adults' health status. In this regard, it could either extend life expectancy via modulation metabolic processes immune system or, case dysbiosis, predispose them to age-related diseases, including bowel inflammatory musculoskeletal diseases neurological disorders. general, microbiome elderly tends present taxonomic functional changes, which can as a target modulate improve population. GM centenarians is unique, faculty-promoting pathways capable preventing counteracting different associated diseases. molecular mechanisms by exhibit anti-ageing properties are mainly based on anti-inflammatory antioxidant actions. This review focuses analysing current knowledge characteristics modifiers, relationship ageing, GM-modulating approaches increase expectancy.
Language: Английский
Citations
33
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: July 18, 2023
Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, there are several limitations that need to be addressed target more types. Natural killer (NK) a type innate represent unique biology surveillance. In particular, NK obtained from heathy donors can serve source for genetically engineered therapies. Therefore, NK-based therapies, including cells, CAR-NK and antibodies induce antibody-dependent cellular cytotoxicity emerged. With recent advances genetic engineering techniques, cell-based become promising approaches wide range cancers, viral infections, senescence. This review provides brief overview characteristics summarizes diseases could benefit addition, we discuss preclinical clinical investigations on adoptive transfer agents modulate activity.
Language: Английский
Citations
29
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11538 - 11538
Published: July 16, 2023
Ageing constitutes the biggest risk factor for poor health and adversely affects integrity function of all cells, tissues, organs in human body. Vascular ageing, characterised by vascular stiffness, endothelial dysfunction, increased oxidative stress, chronic low-grade inflammation, early-stage atherosclerosis, may trigger or exacerbate development age-related diseases, which each year contribute to more than 3.8 million deaths Europe alone necessitate a better understanding mechanisms involved. To this end, large number recent preclinical clinical studies have focused on exponential accumulation senescent cells system paid particular attention specific roles senescence-associated secretory phenotype, proteostasis age-mediated modulation certain microRNA (miRNAs), contribution other major factors, notably diabetes, hypertension, smoking, ageing elderly. The data generated paved way various senotherapeutic interventions, ranging from application synthetic natural senolytics senomorphics attempt modify lifestyle, control diet, restrict calorie intake. However, guidelines, considering severity characteristics need be established before widespread use these agents. This review briefly discusses molecular cellular summarises efficacy widely studied senotherapeutics context ageing.
Language: Английский
Citations
22
Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)
Published: Feb. 13, 2024
Abstract Emerging evidence suggests a potential role for natural killer (NK) cells in neurodegenerative diseases, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. However, the precise function of NK these diseases remains ambiguous. The existence two cell subsets, CD56 bright dim cells, complicates understanding contribution neurodegeneration their functions within context may differ significantly. are potent cytokine secretors considered more immunoregulatory less terminally differentiated than mostly cytotoxic counterparts. Hence, this review focusses on specifically diseases. Moreover, it explores mechanisms underlying ability to enter central nervous system. By consolidating current knowledge, we aim provide comprehensive overview Elucidating impact have implications future therapeutic interventions, potentially ameliorating pathogenesis.
Language: Английский
Citations
13
MedComm, Journal Year: 2024, Volume and Issue: 5(5)
Published: April 24, 2024
Abstract Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades, research into the role of senescence on tumor progression has received widespread attention. While how limits course cancer is well established, also been found to promote certain malignant phenotypes. The tumor‐promoting effect mainly elicited by a senescence‐associated secretory phenotype, which facilitates interaction senescent cells their surroundings. Targeting therefore offers promising technique for therapy. Drugs that pharmacologically restore normal function or eliminate them would assist reestablishing homeostasis cell signaling. Here, we describe its occurrence, impact biology. A “one‐two‐punch” therapeutic strategy first induced, followed use senotherapeutics eliminating introduced. advances application targeting treatment are outlined, an emphasis drug categories, strategies screening, design, efficient targeting. This work will foster thorough comprehension encourage additional within this field.
Language: Английский
Citations
12