Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1944 - 1944

Published: Oct. 31, 2023

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted, leading cardiac damage and massive loss of viable cardiomyocytes. Timely restoration coronary considered gold standard treatment for MI patients limits infarct size; however, this intervention, known as reperfusion, initiates a complex pathological process that somewhat paradoxically also contributes injury. Despite being sterile environment, ischemia/reperfusion (I/R) injury triggers inflammation, which expansion subsequent remodeling wound healing. The immune response comprised subsets both myeloid lymphoid-derived cells act in concert modulate pathogenesis resolution I/R Multiple mechanisms, including altered metabolic status, regulate cell activation function setting acute MI, yet our understanding remains incomplete. While numerous studies demonstrated benefit following strategies target inflammation preclinical models, therapeutic attempts mitigate were less successful. Therefore, further investigation leveraging emerging technologies needed better characterize intricate inflammatory elucidate its influence on progression heart failure.

Language: Английский

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Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(8), P. 556 - 573

Published: March 18, 2024

Language: Английский

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Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within myocardium. Data associated with pro-angiogenic activity mitochondria have not completely elucidated terms cardiac tissue regeneration. Here, we aimed highlight recent studies advantages related application mass How which mechanisms, can reduce aberrant myocardial remodeling via different pathways such as angiogenesis de novo blood formation was discussed detail. We hope that data from current review article help us understand molecular cellular mechanisms transplanted exert their properties

Language: Английский

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Evidence-based practice enhances patient outcomes: Early pressure ulcer detection with biocapacitance technology among critically ill patients

Intensive and Critical Care Nursing, Journal Year: 2025, Volume and Issue: 89, P. 103950 - 103950

Published: Feb. 13, 2025

Language: Английский

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Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 16

Published: Dec. 26, 2022

Background. Myocardial infarction (MI) is a severe clinical condition caused by decreased or complete cessation of blood flow to portion the myocardium. Aconite, lateral roots Aconitum carmichaelii Debx., well-known Chinese medicine for treatment heart failure and related cardiac diseases. The present study aimed at investigating cardioprotective effect aconite on isoproterenol- (ISO)- induced MI. Methods. qualitative analysis aqueous extracts from brained (AEBA) was conducted HPLC. A rat model MI ISO established examine effects AEBA. function assessed echocardiography. serum levels SOD, CK-MB, cTnT, cTnI were detected estimate myocardial injury. pathological changes tissue evaluated 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin-eosin (HE) Masson’s trichrome staining. expressions abnormal vascular remodeling hypoxia-related components inflammation-associated genes proteins RT-qPCR, western blotting, immunofluorescence. Results. contents benzoylaconine, benzoylmesaconine, benzoylhypacoitine, hypaconitine in AEBA 1.35 μg/g, 37.35 57.10 2.46 respectively. obviously improved through promoting echocardiographic parameters, radial strain, circumferential strain. data TTC HE staining disclosed that could significantly reduce infarct size, inhibit inflammatory cell infiltration, decrease fibrosis. Moreover, distinctly suppressed MDA, ISO-induced rats. results RT-qPCR indicated inhibited hypoxia- inflammation-related genes, including VEGF, PKM2, GLUT-1, LDHA, TNF-α, IL-1β, IL-6, COX2. In addition, blotting immunofluorescence analyses further confirmed RT-qPCR. Conclusion. summary, our indicate improve function, alleviating hypoxia, inhibiting response fibrosis tissue.

Language: Английский

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Circular RNA regulatory role in pathological cardiac remodelling

British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Cardiac remodelling involves structural, cellular and molecular alterations in the heart after injury, resulting progressive loss of function ultimately leading to failure. Circular RNAs (circRNAs) are a recently rediscovered class non-coding that play regulatory roles pathogenesis cardiovascular diseases, including Thus, more comprehensive understanding role circRNAs processes governing cardiac may set ground for development circRNA-based diagnostic therapeutic strategies. In this review, current knowledge about circRNA origin, conservation, characteristics is summarized. Bioinformatics wet-lab methods used research discussed. The mechanisms such as cell death, cardiomyocyte hypertrophy, inflammation, fibrosis metabolism highlighted. Finally, key challenges opportunities discussed, orientations future work address pharmacological potential failure proposed.

Language: Английский

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The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways

Genes and Immunity, Journal Year: 2024, Volume and Issue: 25(4), P. 277 - 296

Published: June 22, 2024

Abstract MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust targeting specific genes and signaling pathways. This review focuses on impact of inflammatory pathways triggered during injury highlights inflammation, playing critical pathophysiology Dysregulated expression contributes pathogenesis injury, therefore offers an opportunity restore homeostasis improve patient outcomes. Understanding complex network immunoregulatory could provide novel therapeutic interventions aimed at attenuating excessive inflammation preserving tissue integrity.

Language: Английский

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Cardioprotective effect of curcumin on myocardial ischemia/reperfusion injury: a meta-analysis of preclinical animal studies

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: May 22, 2023

Objective: This meta-analysis aimed to determine the efficacy of curcumin in preventing myocardial ischemia/reperfusion (I/R) injury animal models. Methods: Studies published from inception January 2023 were systematically searched databases including PubMed, Web Science, Embase, China's National Knowledge Infrastructure (CNKI), Wan-Fang database, and VIP database (VIP). The SYRCLE's RoB tool was used methodological quality. Sensitivity analysis subgroup performed when there high heterogeneity. Publication bias assessed using a funnel plot. Results: Thirty-seven studies involving 771 animals included this with methodology quality scores ranging 4 7. results indicated that treatment significantly improved infarction size standard mean difference (SMD) = -5.65; 95% confidence interval (CI): 6.94, -4.36; p < 0.01; I2 90%). sensitivity for infarct showed stable reliable. However, plot asymmetric. species, model, dose, administration, duration. dose statistically significant between subgroups. In addition, cardiac function, enzymes, oxidative stress levels models I/R injury. revealed is publication creatine kinase lactate dehydrogenase. Finally, we inflammatory cytokines apoptosis index. downregulated serum cytokine Conclusion: suggests has excellent potential conclusion needs be further discussed verified large human clinical trials. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42022383901.

Language: Английский

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The recent advancement in the chitosan hybrid-based scaffolds for cardiac regeneration after myocardial infarction

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 300, P. 120266 - 120266

Published: Oct. 26, 2022

Language: Английский

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Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation

BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Feb. 1, 2023

Abstract Background/Aims The activation of the complement system and subsequent inflammatory responses are important features myocardial ischemia/reperfusion (I/R) injury. Exosomes nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on I/R injury by inhibiting inflammation exosomal heat shock protein 90 (HSP90) mediates these effects. Methods Rat hearts underwent 30 min coronary ligation followed 2 h reperfusion. Plasma were isolated from RIPC rats injected into infarcted myocardium immediately after ligation. Sixty randomly divided Sham, I/R, + RIPC-Exo (50 µg/µl), GA (geldanamycin, 1 mg/kg, administration before ligation) groups. Cardiomyocyte apoptosis, release markers (LDH, cTnI CK-MB), infarct size, expression HSP90, component (C)3, C5a, c-Jun N-terminal kinase (JNK), interleukin (IL)-1β, tumor necrosis factor (TNF)-alpha intercellular adhesion molecule -1 (ICAM-1) assessed. Results treatment significantly reduced I/R-induced cardiomyocyte CK-MB) size. These beneficial accompanied decreased C3 C5a expression, levels (IL-1β, TNF-α, ICAM-1), JNK Bax, increased Bcl-2 expression. Meanwhile, HSP90 rat RIPC. However, with inhibitor reversed cardioprotection RIPC-Exo, as well activated component, signalling inflammation, indicating was mediating cardioprotective during I/R. Conclusion Exosomal induced played against injury, its function part linked inhibition system, local systemic ultimately alleviating apoptosis upregulation downregulation proapoptotic Bax.

Language: Английский

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