Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Jan. 27, 2023
After
an
ischemic
stroke
(IS)
occurs,
immune
cells
begin
traveling
to
the
brain
and
system
from
gut
gastrointestinal
tract,
where
most
of
them
typically
reside.
Because
majority
body’s
macrophages
more
than
70%
total
cell
pool
are
found
within
inflammation
responses
in
organs
require
mobilization
a
large
number
cells.
The
bidirectional
communication
pathway
between
is
often
referred
as
gut-brain
axis.
IS
usually
leads
intestinal
motility
disorders,
dysbiosis
microbiota,
leaky
gut,
which
associated
with
poor
prognosis
patients
IS.
In
recent
years,
several
studies
have
suggested
that
play
key
roles
development
IS,
thus
may
become
potential
therapeutic
targets
can
drive
new
strategies.
However,
research
on
after
remains
its
infancy.
A
better
understanding
be
important
for
developing
effective
therapies.
This
review
discusses
immune-related
mechanisms
axis
compiles
provide
ideas
strategies
future
treatment
Brain Behavior & Immunity - Health,
Journal Year:
2024,
Volume and Issue:
38, P. 100763 - 100763
Published: March 29, 2024
Postoperative
Cognitive
Dysfunction
(POCD)
is
a
common
yet
poorly
understood
complication
of
surgery
that
can
lead
to
long-term
cognitive
decline.
The
gut-brain
axis,
bidirectional
communication
system
between
the
central
nervous
and
gut
microbiota,
plays
significant
role
in
maintaining
health.
potential
for
anesthetic
agents
perioperative
medications
modulate
microbiota
influence
trajectory
POCD
suggests
need
more
integrated
approach
care.
Perioperative
medications,
including
opioids
antibiotics,
further
compound
these
disruptions,
leading
dysbiosis
consequent
systemic
neuroinflammation
implicated
impairment.
Understanding
how
surgical
interventions
associated
treatments
affect
this
relationship
crucial
developing
strategies
reduce
incidence
POCD.
Strategies
preserve
promote
healthy
microbiome
may
mitigate
risk
severity
Future
research
should
aim
clarify
mechanisms
linking
flora
alterations
outcomes
explore
targeted
interventions,
such
as
probiotic
supplementation
microbiota-friendly
prescription
practices,
safeguard
function
postoperatively.
Journal of Dental Research,
Journal Year:
2024,
Volume and Issue:
103(5), P. 494 - 501
Published: April 16, 2024
Periodontitis
is
associated
with
an
increased
risk
of
ischemic
stroke,
and
the
may
be
particularly
high
among
young
people
unexplained
stroke
etiology.
Thus,
we
investigated
in
a
case-control
study
whether
periodontitis
or
recent
invasive
dental
treatments
are
young-onset
cryptogenic
(CIS).
We
enrolled
participants
from
multicenter
SECRETO
including
adults
aged
18
to
49
y
presenting
imaging-positive
first-ever
CIS
stroke-free
age-
sex-matched
controls.
Thorough
clinical
radiographic
oral
examination
was
performed.
Furthermore,
measured
serum
lipopolysaccharide
(LPS)
lipotechoic
acid
(LTA)
levels.
Multivariate
conditional
regression
models
were
adjusted
for
factors,
regular
dentist
visits,
patent
foramen
ovale
(PFO)
status.
146
pairs
(median
age
41.9
y;
58.2%
males).
diagnosed
27.5%
patients
20.1%
controls
(
P
<
0.001).
In
fully
models,
periodontal
inflammation
burden
(odds
ratio
[OR],
95%
confidence
interval)
OR
10.48
(3.18–34.5)
severe
7.48
(1.24–44.9).
Stroke
severity
periodontitis,
having
6.43
(1.87–23.0)
stage
III
IV,
grade
C.
Invasive
performed
within
3
mo
prestroke
CIS,
2.54
(1.01–6.39).
Association
between
especially
strong
those
PFO
showing
6.26
(1.72–40.2).
LPS/LTA
did
not
differ
but
displayed
increasing
trend
severity.
procedures
after
controlling
multiple
confounders.
However,
role
bacteremia
as
mediator
this
confirmed.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Jan. 27, 2023
After
an
ischemic
stroke
(IS)
occurs,
immune
cells
begin
traveling
to
the
brain
and
system
from
gut
gastrointestinal
tract,
where
most
of
them
typically
reside.
Because
majority
body’s
macrophages
more
than
70%
total
cell
pool
are
found
within
inflammation
responses
in
organs
require
mobilization
a
large
number
cells.
The
bidirectional
communication
pathway
between
is
often
referred
as
gut-brain
axis.
IS
usually
leads
intestinal
motility
disorders,
dysbiosis
microbiota,
leaky
gut,
which
associated
with
poor
prognosis
patients
IS.
In
recent
years,
several
studies
have
suggested
that
play
key
roles
development
IS,
thus
may
become
potential
therapeutic
targets
can
drive
new
strategies.
However,
research
on
after
remains
its
infancy.
A
better
understanding
be
important
for
developing
effective
therapies.
This
review
discusses
immune-related
mechanisms
axis
compiles
provide
ideas
strategies
future
treatment
