Frontiers in Allergy,
Journal Year:
2022,
Volume and Issue:
3
Published: Sept. 12, 2022
MicroRNAs
(miRs)
have
gained
scientific
attention
due
to
their
importance
in
the
pathophysiology
of
allergic
diseases
as
well
potential
biomarkers
allergen-specific
treatment
options.
Their
function
post-transcriptional
regulators,
controlling
various
cellular
processes,
is
high
since
any
single
miR
can
target
multiple
mRNAs,
often
within
same
signalling
pathway.
MiRs
alter
dysregulated
expression
certain
responses
and
contribute
or
cause,
but
some
cases
prevent
repress,
development
diseases.
In
this
review
article,
we
describe
current
research
on
role
specific
miRs
regulating
immune
epithelial
cells
specialized
response
stimuli,
diseases,
regulation
therapeutic
approach
immunotherapy
(AIT).
Despite
fact
that
AIT
has
been
used
successfully
a
causative
option
more
than
century,
very
little
known
about
mechanisms
its
connections
with
microRNAs.
order
fill
gap,
aims
provide
an
overview
knowledge.
Food
allergies
are
a
growing
public
health
concern
worldwide,
especially
in
children
and
young
adults.
Allergen-specific
IgE
plays
central
role
the
pathogenesis
of
food
allergies,
but
their
titers
poorly
correlate
with
allergy
development.
Host
immune
systems
yield
allergen-specific
immunoglobulin
(Ig)A,
IgG
subclasses
low
or
high
affinities
differential
Fc
N-glycosylation
patterns
that
can
affect
allergic
reaction
to
multiple
ways.
High
affinity
is
required
induce
strong
mast
cell
activation
eventually
leading
anaphylaxis
while
even
inhibit
development
clinically
relevant
symptoms.
IgA
antibodies
IgE-mediated
through
various
mechanisms,
thereby
protecting
IgE-positive
individuals
from
The
production
allergenic
potential
seems
be
affected
by
signaling
strength
individual
B
receptors,
cytokines
T
cells.
This
review
provides
an
overview
diversity
response
diverse
roles
allergy.
Frontiers in Allergy,
Journal Year:
2022,
Volume and Issue:
3
Published: Sept. 12, 2022
MicroRNAs
(miRs)
have
gained
scientific
attention
due
to
their
importance
in
the
pathophysiology
of
allergic
diseases
as
well
potential
biomarkers
allergen-specific
treatment
options.
Their
function
post-transcriptional
regulators,
controlling
various
cellular
processes,
is
high
since
any
single
miR
can
target
multiple
mRNAs,
often
within
same
signalling
pathway.
MiRs
alter
dysregulated
expression
certain
responses
and
contribute
or
cause,
but
some
cases
prevent
repress,
development
diseases.
In
this
review
article,
we
describe
current
research
on
role
specific
miRs
regulating
immune
epithelial
cells
specialized
response
stimuli,
diseases,
regulation
therapeutic
approach
immunotherapy
(AIT).
Despite
fact
that
AIT
has
been
used
successfully
a
causative
option
more
than
century,
very
little
known
about
mechanisms
its
connections
with
microRNAs.
order
fill
gap,
aims
provide
an
overview
knowledge.
