Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 4, 2023
Oncolytic
viral
(OV)
therapies
are
promising
novel
treatment
modalities
for
cancers
refractory
to
conventional
treatment,
such
as
glioblastoma,
within
the
central
nervous
system
(CNS).
Although
OVs
have
received
regulatory
approval
use
in
CNS,
efficacy
is
hampered
by
obstacles
related
delivery,
under-/over-active
immune
responses,
and
"immune-cold"
nature
of
most
CNS
malignancies.
SUMO,
Small
Ubiquitin-like
Modifier,
a
family
proteins
that
serve
high-level
regulator
large
variety
key
physiologic
processes
including
host
response.
The
SUMO
pathway
has
also
been
implicated
pathogenesis
both
wild-type
viruses
As
such,
intersection
OV
biology
with
makes
SUMOtherapeutics
particularly
interesting
adjuvant
enhancement
alone
concert
other
immunotherapeutic
agents.
Accordingly,
authors
herein
provide:
1)
an
overview
its
role
malignancies;
2)
describe
current
state
CNS-targeted
OVs;
3)
interplay
between
lifecycle
The Journal of Experimental Medicine,
Journal Year:
2023,
Volume and Issue:
220(3)
Published: Jan. 13, 2023
The
cGAS-STING
pathway
is
an
evolutionarily
conserved
immune
signaling
critical
for
microbial
defense.
Unlike
other
innate
pathways
that
largely
rely
on
stationary
cascades
of
events,
STING
highly
mobile
in
the
cell.
activated
ER,
but
only
signals
after
it
arrives
Golgi,
and
then
quickly
degraded
by
lysosome.
Each
step
trafficking
through
secretory
regulated
host
factors.
Homeostatic
via
COPI-,
COPII-,
clathrin-coated
vesicles
important
maintaining
baseline
tissue
cellular
immunity.
Aberrant
vesicular
or
lysosomal
dysfunction
produces
signal
STING,
which
often
leads
to
pathology
mice
humans.
Many
trafficking-mediated
diseases
appear
impact
central
nervous
system,
leading
neurodegeneration.
Therefore,
introduces
a
new
dimension
likely
has
broad
implications
human
disease.
Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
29(1)
Published: July 6, 2023
Abstract
The
metabolism
of
glucose
and
lipids
is
essential
for
energy
production
in
the
body,
dysregulation
metabolic
pathways
these
molecules
implicated
various
acute
chronic
diseases,
such
as
type
2
diabetes,
Alzheimer’s
disease,
atherosclerosis
(AS),
obesity,
tumor,
sepsis.
Post-translational
modifications
(PTMs)
proteins,
which
involve
addition
or
removal
covalent
functional
groups,
play
a
crucial
role
regulating
protein
structure,
localization
function,
activity.
Common
PTMs
include
phosphorylation,
acetylation,
ubiquitination,
methylation,
glycosylation.
Emerging
evidence
indicates
that
are
significant
modulating
lipid
by
modifying
key
enzymes
proteins.
In
this
review,
we
summarize
current
understanding
regulatory
mechanisms
metabolism,
with
focus
on
their
involvement
disease
progression
associated
aberrant
metabolism.
Furthermore,
discuss
future
prospects
PTMs,
highlighting
potential
gaining
deeper
insights
into
related
diseases.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 9, 2024
Galectin-9
(Gal-9)
is
a
vital
member
of
the
galectin
family,
functioning
as
multi-subtype
galactose
lectin
with
diverse
biological
roles.
Recent
research
has
revealed
that
Gal-9’s
interaction
tumors
an
independent
factor
influences
tumor
progression.
Furthermore,
Gal-9
in
immune
microenvironment
cross-talks
tumor-associated
cells,
informing
clarification
identity
checkpoint.
A
thorough
investigation
into
role
various
cancer
types
and
its
could
yield
novel
strategies
for
subsequent
targeted
immunotherapy.
This
review
focuses
on
latest
advances
understanding
direct
indirect
cross-talk
between
hematologic
malignancies,
addition
to
solid
tumors.
In
addition,
we
discuss
prospects
immunotherapy,
including
ligand
TIM-3
potential
immune-combination
therapy.
EMBO Reports,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Histone
deacetylase
HDAC6
has
been
implicated
in
regulating
antiviral
innate
immunity.
However,
its
precise
function
response
to
DNA
virus
infection
remains
elusive.
Herein,
we
find
that
deficiency
promotes
the
activation
of
cGAS-STING
signaling
and
type
I
interferon
(IFN)
production,
both
vitro
vivo,
resulting
a
decrease
HSV-1
infection.
Mechanistically,
deacetylates
tripartite
motif
protein
56
(TRIM56)
at
K110
mice,
thereby
impairing
monoubiquitination
cGAS
binding
ability.
Overexpression
TRIM56
K110Q
protects
mice
against
Notably,
different
amino
acids
position
110
human
mouse
cause
species-specific
IFN
responses.
Further,
show
during
early
stages
infection,
viral
US3
phosphorylates
inhibit
cGAS-mediated
response.
Our
results
suggest
inhibits
through
deacetylation
manner.
Cancer Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 20
Published: Jan. 3, 2024
The
intricate
interplay
between
the
human
immune
system
and
cancer
development
underscores
central
role
of
immunotherapy
in
treatment.
Within
this
landscape,
innate
system,
a
critical
sentinel
protecting
against
tumor
incursion,
is
key
player.
cyclic
GMP-AMP
synthase
(cGAS)
stimulator
interferon
genes
(STING)
pathway
has
been
found
to
be
linchpin
immunity:
activation
signaling
orchestrates
production
type
I
(IFN-α/β),
thus
fostering
maturation,
differentiation,
mobilization
effectors
microenvironment.
Furthermore,
STING
facilitates
release
presentation
antigens,
therefore
an
attractive
target
for
immunotherapy.
Current
strategies
activate
pathway,
including
use
pharmacological
agonists,
have
made
substantial
advancements,
particularly
when
combined
with
checkpoint
inhibitors.
These
approaches
shown
promise
preclinical
clinical
settings,
by
enhancing
patient
survival
rates.
This
review
describes
evolving
understanding
cGAS-STING
pathway’s
involvement
biology
therapy.
Moreover,
explores
classical
non-classical
providing
insights
into
their
mechanisms
action
potential
optimizing
strategies.
Despite
challenges
complexities,
promising
avenue
treatment
efficacy,
revolutionize
outcomes.
