Exploring the Structure–Activity Relationship of F. velutipes Polysaccharide: A Novel Promising Anti-Inflammatory and Intestinal Barrier-Protective Molecule Extracted by Ultrasound DOI
Xin Chen, Jingsi Zhang, Qiping Zhan

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Ultrasonic extraction has the advantage of higher efficiency in F. velutipes polysaccharides (FVP), but structure and activities with application value FVP extracted by ultrasound (FVPUs) were unclear. FVPUs separated into FVPU1 FVPU2 subjected to structural analysis, anti-inflammatory activity, intestinal mucosal protection activity research. Compared FVPU1, exhibited a molecular weight, smaller crystallinity index, contents galactose, mannose, fucose, more stable triple helix structure, stronger binding ability Congo red calcium ions. The research disclosed that demonstrated significant alleviating abnormal surge NO, IL-1β, IL-6, TNF-α. This outcome was accomplished through suppression overactive TLR4/MyD88/NLRP3 signaling pathway. Furthermore, decreased death rate cells enhanced expression Occludin, ZO-1, trefoil factor-3 (TFF-3), epidermal growth factor (EGF), prostaglandin E synthase 2 (PTGES2) (p < 0.05). study sought advance comprehension relationship between polysaccharides, contributing valuable insights field food science.

Language: Английский

An injectable sequential dual-crosslinking catechol-functionalized hyaluronic acid hydrogel for enhanced regeneration of full-thickness burn injury DOI
Wenning Zhang, Shuo Zhang, Tianyu Zhao

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 545 - 555

Published: April 10, 2024

Language: Английский

Citations

7
Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen Effect DOI Creative Commons
Dmitri Atiakshin, M. Yu. Soboleva,

Dmitry Nikityuk

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 348 - 348

Published: Feb. 24, 2023

The mechanisms of regeneration for the fibrous component connective tissue dermis are still insufficiently studied. aim this study was to evaluate effectiveness use molecular hydrogen on local therapy a II degree burn wound with intensification collagen fibrillogenesis in skin. We analyzed involvement mast cells (MCs) fibers using water high content and therapeutic ointment cell wounds. Thermal burns led an increase skin MC population, accompanied by systemic rearrangement extracellular matrix. treatment wounds stimulated processes activating formation dermis, accelerating healing. Thus, comparable effects ointment. remodeling matrix correlated decrease area damaged Skin induced activation secretory activity MCs may be one possible points implementation biological positive repair can used clinical practice after thermal exposure.

Language: Английский

Citations

14
β-Carotene laden antibacterial and antioxidant gelatin/polyglyceryl stearate nano-hydrogel system for burn wound healing application DOI

Zenab Darban,

Hemant Singh, Udisha Singh

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 255, P. 128019 - 128019

Published: Nov. 10, 2023

Language: Английский

Citations

14
Topical Noneuphoric Phytocannabinoid Elixir 14 Reduces Inflammation and Mitigates Burn Progression DOI

Sean Christy,

Anders H. Carlsson, David A. Larson

et al.

Journal of Surgical Research, Journal Year: 2024, Volume and Issue: 296, P. 447 - 455

Published: Feb. 5, 2024

Language: Английский

Citations

5
Multifunctional hydrogels for wound healing DOI Creative Commons
Xinyu Yang, Jinyan Li, Xi Chen

et al.

Journal of Polymer Engineering, Journal Year: 2024, Volume and Issue: 44(3), P. 173 - 194

Published: Feb. 8, 2024

Abstract The process of wound healing is complex and dynamic. Given the unique nature skin, requires dressings that meet a wide range functional requirements. Due to their structure properties, hydrogel provide ideal conditions for supporting can be enhanced with additional functions specific requirements different types wounds. Compared traditional dressings, newly developed dressing offers several advantages, including its soft texture, ability retain moisture, oxygen permeability, comfort. With advancement medical technology, higher demands are being placed on functionality dressings. Therefore, this paper comprehensive overview various functions. These primarily include hemostatic antibacterial angiogenesis-promoting other also reviews research application these in recent years.

Language: Английский

Citations

5
Free Flap Failure and Complications in Acute Burns: A Systematic Review and Meta-analysis DOI Creative Commons
Júlia Adriana Kasmirski, Mario Alessandri‐Bonetti,

Hilary Liu

et al.

Plastic & Reconstructive Surgery Global Open, Journal Year: 2023, Volume and Issue: 11(10), P. e5311 - e5311

Published: Oct. 1, 2023

Severe acute burn injuries represent a challenge to the reconstructive surgeon. Free flap reconstruction might be required in cases of significant critical structure exposure and soft tissue deficits, when local options are unavailable. This study aimed determine free complication rate patients.A systematic review meta-analysis were conducted reported according Preferred Reporting Items for Systematic Reviews Meta-Analysis guidelines registered on International Prospective Register database (CRD42023404478). The following databases accessed: Embase, PubMed, Web Science, Cochrane Library. primary outcome was failure rate.The identified 31 articles inclusion. A total 427 patients (83.3% men, 16.7% women) accounting 454 flaps included. mean patient age 36.21 [95% confidence interval (CI), 31.25-41.16]. Total loss 9.91% CI, 7.48%-13.02%], partial 4.76% 2.66%-8.39%]. venous thrombosis 6.41% 3.90%-10.36%] arterial 5.08% 3.09%-8.26%]. Acute return operating room occurred 20.63% [16.33%-25.71%] cases. Stratified by body region, lower extremity had 8.33% 4.39%-15.24%], whereas upper extremity, 6.74% 3.95%-11.25%].This highlights high risk complications patients.

Language: Английский

Citations

11
Outcomes of Burn Injury in Organ Transplant Patients: A 12-Year Review DOI

Rebecca Hohsfield,

Darko Quispe Orozco, Hilary Y. Liu

et al.

Journal of Burn Care & Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Journal Article Corrected proof Outcomes of Burn Injury in Organ Transplant Patients: A 12-Year Review Get access Rebecca Hohsfield, BS, BS Department Plastic Surgery, University Pittsburgh Medical Center, Pittsburgh, PA, United States https://orcid.org/0009-0000-1992-1932 Search for other works by this author on: Oxford Academic Google Scholar David Orozco, MD, MD https://orcid.org/0000-0002-3236-228X Hilary Y Liu, Francesco M Egro, MSc, MRCS StatesDepartment Corresponding author: M. Egro ([email protected]). https://orcid.org/0000-0003-1536-7713 Care & Research, irae212, https://doi.org/10.1093/jbcr/irae212 Published: 06 January 2025 history and typeset: 13

Language: Английский

Citations

0
Self-Healing Oxidized Dextran/Sodium Alginate Hydrogel Dressing with Hemostatic Activity Speeds Up Wound Healing in Burn Injuries DOI
Jingya Zhao,

Huiqing Zhu,

Tianmin Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(2), P. 2940 - 2951

Published: Jan. 7, 2025

This study introduced a hydrogel dressing, termed SODex-gel, which was constructed by establishing Schiff base and hydrogen bonds with the precursors of oxidized dextran (ODex) succinic dihydrazide (SD)-modified sodium alginate (SD-mod-SA). Through comprehensive in vitro vivo studies, adhesive properties, self-healing capabilities, hemostatic potential, wound healing efficacy SODex-gel dressing were meticulously evaluated. The 1H NMR, FTIR, TGA analyses confirmed fabrication its constituent elements. Scanning electron microscopy (SEM) imaging showcased uniform pore structures dressing. In assessments demonstrated that noncytotoxic exhibits strong adhesion, enabling it to attach various surfaces. Noteworthy findings from studies mouse liver incisions tail amputation models proved ability Moreover, their remarkable wound-healing capabilities prominently through treatment model afflicted burn skin injuries. Evidence neovascularization effects corroborated upregulation CD31 vascular endothelial growth factor (VEGF) expression treated samples. Collectively, experimental data unequivocally established is promising therapeutic approach accelerate recovery, thereby exhibiting substantial potential for clinical applications treating

Language: Английский

Citations

0
A scATAC-seq atlas of stasis zone in rat skin burn injury wound process DOI Creative Commons

Ruikang Li,

Jiashan Li, Shuai Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

Burn injuries often leave behind a "stasis zone", region of tissue critically important for determining both the severity injury and potential recovery. To understand intricate cellular epigenetic changes occurring within this critical zone, we utilized single-cell assay transposase-accessible chromatin sequencing (scATAC-seq) to profile over 31,500 cells from healthy rat skin stasis zone at nine different time points after burn injury. This comprehensive approach revealed 26 distinct cell types dynamic shifts in proportions these time. We observed gene activation patterns various stages post-burn, highlighting key players immune activation, regeneration, blood vessel repair. Importantly, our analysis uncovered regulatory networks governing genes, offering valuable insights into mechanisms orchestrating wound healing. molecular atlas provides powerful resource developing targeted therapies aimed improving recovery minimizing long-term consequences.

Language: Английский

Citations

0
Investigation of the Effect of Camellia Sinensis Essence Cream on Skin Burns DOI Creative Commons
Tolga Mercantepe, Adnan Yılmaz, Atilla Topçu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 176 - 176

Published: Jan. 25, 2025

Background/Objective: Burn injuries are among the most common causes of trauma globally, affecting millions annually. Current treatments often rely on topical agents, but alternatives to synthetic formulations increasingly sought due safety and efficacy concerns. This study aimed evaluate therapeutic effects a cream containing Camellia sinensis (white tea) extract third-degree burn-induced skin lesions in rat model. Methods: Thirty-two male Sprague-Dawley rats were randomized into four groups: control, only, + extract, cream. Skin biopsies evaluated using histopathological, immunohistochemical, biochemical methods. Malondialdehyde (MDA) glutathione (GSH) levels measured assess oxidative stress, while histological damage immunoreactivity for collagen I, III, NF-kβ/p65, TNF-alfa, 8-OhDG, caspase-3 analyzed. Results: The significantly reduced MDA increased GSH compared burn-only group (p < 0.001). Histological analysis revealed enhanced epidermal regeneration dermal damage. immunohistochemical findings demonstrated caspase-3, III immunopositivity cream-treated Conclusions: significant protective reparative damage, suggesting its potential as natural, effective, safe alternative burn management.

Language: Английский

Citations

0