Impact of Fermented Milk On Gut Microbiota And Human Health: A Comprehensive Review

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(3)

Published: Jan. 31, 2025

Language: Английский

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Short-Chain Fatty Acids in the Microbiota–Gut–Brain Axis: Role in Neurodegenerative Disorders and Viral Infections

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(6), P. 1045 - 1062

Published: March 3, 2023

The gut-brain axis (GBA) is the umbrella term to include all bidirectional communication between brain and gastrointestinal (GI) tract in mammalian body. Evidence from over two centuries describes a significant role of GI microbiome health disease states host organism. Short-chain fatty acids (SCFAs), mainly acetate, butyrate, propionate that are physiological forms acetic acid, butyric propionic acid respectively, bacteria derived metabolites. SCFAs have been reported influence cellular function multiple neurodegenerative diseases (NDDs). In addition, inflammation modulating properties make them suitable therapeutic candidates neuroinflammatory conditions. This review provides historical background GBA current knowledge individual central nervous system (CNS) disorders. Recently, few reports also identified effects metabolites case viral infections. Among these viruses, flaviviridae family associated with neuroinflammation deterioration CNS functions. this context, we additionally introduce SCFA based mechanisms different pathogenesis understand former's potential as agents against flaviviral disease.

Language: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

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Homeostasis and Dysbiosis of the Intestinal Microbiota: Comparing Hallmarks of a Healthy State with Changes in Inflammatory Bowel Disease

Microorganisms, Journal Year: 2022, Volume and Issue: 10(12), P. 2405 - 2405

Published: Dec. 5, 2022

The gut microbiota, which represent a community of different microorganisms in the human intestinal tract, are crucial to preserving health by participating various physiological functions and acting as metabolic organ. In conditions, microbiota-host partnership exerts homeostatic stability; however, changes microbiota composition (dysbiosis) an important factor pathogenesis inflammatory bowel disease its two main entities: ulcerative colitis Crohn's disease. incidence prevalence these conditions have increased rapidly last decade, becoming significant problem for healthcare system true challenge finding novel therapeutic solutions. issue is that, despite numerous studies, etiopathogenesis not completely clear. Based on current knowledge, chronic inflammation occurs due altered environmental factors, well complex interplay between genetic predisposition host inappropriate innate acquired immune response. It note that development biological immunomodulatory therapy has led progress treating Certain lifestyle approaches-including fecal transplantation nutritional supplementation with probiotics, prebiotics, synbiotics-have offered solutions dysbiosis management paved way towards restoring healthy microbiome, only minimal long-term unfavorable effects.

Language: Английский

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The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2097 - 2097

Published: April 27, 2023

Describing diet-related effects on the gut microbiome is essential for understanding its interactions with fat and/or sugar-rich diets to promote obesity-related metabolic diseases. Here, we sequenced V3-V4 hypervariable region of bacterial 16S rRNA gene study composition and dynamics adult mice fed rich in sugar, at 9 18 weeks diet. Under high-fat, high-sugar diet, abundances

Language: Английский

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Relationship between changes in microbiota induced by resveratrol and its anti-diabetic effect on type 2 diabetes

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 6, 2023

Although a general healthy gut microbiota cannot be defined due to numerous internal and external individual factors, such as sex, age, ethnicity, genetics, environment, diet drugs affect its composition, certain microbial species compositions seem related the progression of insulin resistance type 2 diabetes, well development microvascular macrovascular complications diabetes. The present review aimed at gathering reported information describing how resveratrol induced changes in composition can mediate positive effects this polyphenol on glucose homeostasis under diabetic conditions, both animals humans. Based fact that some observed patients are reversed by treatment, taking into account mediated similar those anti-diabetic metformin, it proposed four genera, Alistipes, Allobaculum, Desulfovibrio Blautia could involved benefits glycameic control. Nevertheless limitations research field: (a) number studies analyzing same cohort animals, order know potential involvement phenolic compound, very scarce practically inexistent case humans., (b) inconsistencies concerning changes, (c) experimental design used do not allow researchers establish causal relationship between effect, vast majority studies, (d) knowledge about role each bacteria glycaemic control is sufficient so far.

Language: Английский

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DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering

Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

In inflammatory bowel diseases (IBD), the most promising therapies targeting cytokines or immune cell trafficking demonstrate around 40% efficacy. As IBD is a multifactorial inflammation of intestinal tract, single-target approach unlikely to solve this problem, necessitating an alternative strategy that addresses its variability. One often overlooked by pharmaceutically driven therapeutic options address impact environmental factors. This somewhat surprising considering increasingly viewed as condition heavily influenced such factors, including diet, stress, and pollution-often referred "Western lifestyle". IBD, responses result from complex interplay among genetic background patient, molecules, cells, local microenvironment where danger- microbe-associated molecular patterns (D/MAMPs) provide adjuvant-rich environment. Through activating DAMP receptors, array pro-inflammatory factors can stimulate, for example, NLRP3 inflammasome-a major amplifier response in various cells via non-specific bystander activation myeloid (e.g., macrophages) lymphocytes tissue-resident memory T cells). Current biological treatment approaches dampen response, but without reducing exposure e.g., changing diet (reducing ultra-processed foods), landscape never resolved continues drive mucosal dysregulation. Thus, are not enough put out fire. The resultant smoldering, low-grade diminishes physiological resilience (micro)environment, perpetuating state chronic disease. Therefore, our hypothesis posits successful interventions must complexity disease simultaneously all modifiable aspects: innate immunity microbiota, adaptive cytokines, relate (micro)environment. Thus be comprehensively treated across nano-, meso-, microscales, rather than with focus on single targets. A broader perspective also includes adapt DAMPing (micro)environment warranted.

Language: Английский

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Long-lasting Depressive Behavior of Adolescent Chronically Stressed Mice is Mediated by Gut Microbiota Dysbiosis

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

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Volatilome and machine learning in ischemic heart disease: Current challenges and future perspectives

World Journal of Cardiology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 21, 2025

Integrating exhaled breath analysis into the diagnosis of cardiovascular diseases holds significant promise as a valuable tool for future clinical use, particularly ischemic heart disease (IHD). However, current research on volatilome (exhaled composition) in remains underexplored and lacks sufficient evidence to confirm its validity. Key challenges hindering application diagnosing IHD include scarcity studies (only three published papers date), substantial methodological bias two these studies, absence standardized protocols implementation. Additionally, inconsistencies methodologies-such sample collection, analytical techniques, machine learning (ML) approaches, result interpretation-vary widely across further complicating their reproducibility comparability. To address gaps, there is an urgent need establish unified guidelines that define best practices data analysis, ML integration, biomarker annotation. Until are systematically resolved, widespread adoption reliable diagnostic distant goal rather than imminent reality.

Language: Английский

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Antibiotics and Antimicrobial Resistance Genes in a Gut Microbiota as a Reservoir—A Review

Advanced Gut & Microbiome Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The human microbiota is one of the most powerful sites for antibiotic resistance (AR) genes. It home to thousands microbes at various stages development. complex inner environment has potential affect host’s immunity, metabolism, and genetic makeup. gut an incredibly high level gene diversity. Its 3.3 million nonredundant genes even outnumber 150 total genomes. In gut, where 10–100 trillion diversity‐enhanced microbe cells reside, horizontal transfer (HGT) prevalent occurs a rate approximately 25 times higher than in any other ecosystem. AR threatens global health by causing stronger infection rates death tolls. nonmedical setting that aids spread antimicrobial (AMR) microbiome. Antibiotic (ARGs) from commensal, anthropogenic, environmental make up resistome. evolutionary force use antibiotics agriculture medicine increases AMR. dynamics AMR are significantly influenced diverse microbial phyla microbiota. Within gastrointestinal tract, ARGs traded transferred between bacterial species quite often. This emphasizes how important it we understand body functions on inside as well outside sources infections. could potentially come oral Even absence direct selection pressure, linked can still be expressed there. epidemic claims millions lives poses serious risk public economy. Bacterial evolution, overuse misuse, genetically modified foods, drug‐resistant pathogens through international travel possibly contributing Sustaining requires surveillance, which hampered inadequate data collection, knowledge gaps, low awareness. addition raising rates, also raises healthcare costs, diminishes treatment effectiveness, promotes growth bacteria. Without considering agriculture, gap, or proper antibiotics, biological factors have contributed escalation research summarizes current gaps antimicrobial‐ antibiotic‐resistant contribution AR.

Language: Английский

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