Unraveling the Immunometabolism Puzzle: Deciphering Systemic Sclerosis Pathogenesis DOI Creative Commons
Maryam Masoumi,

Ali Bodaghi,

Hossein Khorramdelazad

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35445 - e35445

Published: July 31, 2024

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder skin and organ fibrosis manifestation, vasculopathy, immune dysregulation. A growing amount research indicates that plays significant role in diseases, including SSc. review explores intricate interplay between dysfunction metabolic alterations, focusing metabolism glucose, lipids, amino acids, TCA (tricarboxylic acid) cycle, oxidative stress disease. According to recent research, there are changes various pathways could trigger or perpetuate Glycolysis play pivotal through inducing fibrosis. Dysregulated fatty acid β-oxidation (FAO) consequent lipid result dysregulated extracellular matrix (ECM) breakdown induction. altered acids can significantly be involved mechanisms. Reactive oxygen species (ROS) production has crucial damage patients. Indeed, involvement highlighted, which offers potential therapeutic avenues. underscores need for comprehensive studies unravel multifaceted mechanisms driving progression.

Language: Английский

Unraveling the Immunometabolism Puzzle: Deciphering Systemic Sclerosis Pathogenesis DOI Creative Commons
Maryam Masoumi,

Ali Bodaghi,

Hossein Khorramdelazad

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35445 - e35445

Published: July 31, 2024

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder skin and organ fibrosis manifestation, vasculopathy, immune dysregulation. A growing amount research indicates that plays significant role in diseases, including SSc. review explores intricate interplay between dysfunction metabolic alterations, focusing metabolism glucose, lipids, amino acids, TCA (tricarboxylic acid) cycle, oxidative stress disease. According to recent research, there are changes various pathways could trigger or perpetuate Glycolysis play pivotal through inducing fibrosis. Dysregulated fatty acid β-oxidation (FAO) consequent lipid result dysregulated extracellular matrix (ECM) breakdown induction. altered acids can significantly be involved mechanisms. Reactive oxygen species (ROS) production has crucial damage patients. Indeed, involvement highlighted, which offers potential therapeutic avenues. underscores need for comprehensive studies unravel multifaceted mechanisms driving progression.

Language: Английский

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