Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes DOI

Dongxiao Lu,

Haohan Sun,

Hao Fan

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 563, P. 84 - 92

Published: Nov. 8, 2024

Language: Английский

Ferroptosis: Promising approach for cancer and cancer immunotherapy DOI
Shuyue Zheng,

Xin‐Yuan Guan

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216152 - 216152

Published: April 4, 2023

Language: Английский

Citations

38
M1-type microglia-derived exosomes contribute to blood–brain barrier damage DOI
Wen Jiang,

Yan Wu,

Ailan Pang

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1835, P. 148919 - 148919

Published: April 6, 2024

Language: Английский

Citations

9
Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer’s Disease DOI

Yaoxue Guo,

Junli Zhao, Yizhi Liu

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 11, 2025

Language: Английский

Citations

1
Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets in cancer DOI Creative Commons

Muhammad Azhar Ud Din,

Yan Lin,

Naijian Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 11, 2024

Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function ferroptosis in aetiology development cancer other disorders. Consequently, harnessing for disease treatment has diverted interest researchers field basic clinical research. The ubiquitin-proteasome system (UPS) represents a primary protein degradation pathway eukaryotes. It involves labelling proteins be degraded ubiquitin (Ub), followed recognition proteasome. Dysfunction UPS can contribute diverse pathological processes, emphasizing importance maintaining organismal homeostasis. regulation stability critical component intricate molecular mechanism underlying death. Moreover, involvement regulating death-related molecules signaling pathways, providing valuable insights targeted strategies. Besides, it highlights potential as promising target therapy, combination between UPS. mechanisms ferroptosis, including key regulators such glutathione peroxidase 4 (GPX4), cysteine/glutamate transporter (system XC-), metabolism, are thoroughly examined, alongside role modulating abundance activity crucial ferroptotic death, GPX4, nuclear factor erythroid 2–related 2 (NRF2). As pivotal regulatory macromolecular homeostasis, substantially impacts directly or indirectly associated pathways. This review explores diseases with ferroptosis.

Language: Английский

Citations

7
The dual role of microglia in intracerebral hemorrhage DOI
Yue Sun,

Wentao Sun,

Jiawei Liu

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 473, P. 115198 - 115198

Published: Aug. 10, 2024

Language: Английский

Citations

5
CircRNA circACTN4 Promotes the Progression of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the miR-424-5p/NCAPG/Wnt Axis DOI Creative Commons
Jie Shan,

Junxia Pu,

Xiaohao Chen

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 1, 2025

Growing research reveals that circular RNAs (circRNAs) play a major part in the progression and development of cancer. Here, we investigated oncogenic function regulatory mechanisms circRNA circACTN4 hepatocellular carcinoma (HCC), particularly tumor epithelial-mesenchymal transition (EMT). In vitro functional assays (Cell Counting Kit 8, TUNEL, scratch wound healing, invasion assays) HCC cell lines, alongside vivo analyses subcutaneous tumors nude model mice, were employed to assess impact on proliferation. Interactions concerning circACTN4, microRNA (miR)-424-5p, non-SMC condensing I complex subunit G (NCAPG) have been assessed deploying luciferase reporter also quantitative reverse transcription PCR investigation transcripts tissues. Findings indicated high expression HCC, promoted proliferation, while inhibiting apoptosis cells, correlated with poor prognosis. Mechanistically, served as rival internal RNA for miR-424 5p, controlling NCAPG level initiating Wnt/β-catenin signaling routes, which turn impacted EMT machinery HCC. According our surveys, circACTN4/miR-424 5p/NCAPG axis could be an intriguing candidate therapy address treatment

Language: Английский

Citations

0
Microglia-derived sEV: Friend or foe in the pathogenesis of cognitive impairment DOI
Lilin Chen, Wei Wang

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111287 - 111287

Published: Feb. 1, 2025

Language: Английский

Citations

0
Research Progress on the Mechanisms of Microglial Extracellular Vesicles Affecting the Prognosis of Ischemic Stroke DOI
Yang An, Gang Su, Wei Chen

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105949 - 105949

Published: Feb. 1, 2025

Language: Английский

Citations

0
PTEN: a new dawn in Parkinson’s disease treatment DOI Creative Commons
Xiuna Yang, Tianqi Liu, Hong Cheng

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 10, 2025

In recent years, the study of phosphatase and tension homolog (PTEN) has gradually become a research hotspot. As an important oncogene, role PTEN in cancer long been widely recognized intensively studied, but it relatively less studied other diseases. Parkinson’s disease (PD) is neurodegenerative refractory commonly observed middle-aged elderly individuals. The etiology pathogenesis PD are numerous, complex, incompletely understood. With continuous deepening research, numerous studies have proven that related to occurrence PD. this review, we discuss relationship between through phosphorylation ubiquitination possible regulatory mechanisms, including RNA molecules, exosomes, transcriptional regulation, chemical modification, subtype variation, with aim clarifying better elucidating its pathogenesis. Finally, summarize shortcomings highlight great potential future application clinical treatment. These findings provide ideas new perspectives for use as therapeutic target targeted drug development future.

Language: Английский

Citations

0
The role of neuroglial cells communication in ischemic stroke DOI Creative Commons
Yunling Yu, Xinglan Liao, Xinyu Xie

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 209, P. 110910 - 110910

Published: Feb. 27, 2024

Ischemic stroke is one of the leading causes death and disability globally, but its treatment options are limited due to therapeutic window reperfusion injury constraints. Microglia, astrocytes, oligodendrocytes major components neurovascular unit, there substantial evidence suggesting their contributions maintaining homeostasis in central nervous system. Neuroglial cells participate neuronal physiological functions repair damaged neurons through various communication methods, including gap junctions, chemical signaling, extracellular vesicles, conjunction with other unit. Ischemia-induced microglia astrocytes polarize into "M1/M2" "A1/A2" phenotypes exert neurotoxic or neuroprotective effects by releasing soluble factors, secreting forming syncytia networks acute (<72 h), subacute (>72 chronic phases (>6 weeks). Apoptosis ischemic hypoxia leads white matter injury, causing long-term cognitive dysfunction, promoting oligodendrogenesis a crucial direction for achieving functional recovery stroke. In this article, we summarize cellular interactions following cerebral ischemia, analyze roles neuroglial vesicles different stages stroke, further explore strategies intervening

Language: Английский

Citations

3