Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 9, 2024
Reproductive
success
hinges
on
the
presence
of
a
robust
and
functional
placenta.
Examining
placenta
provides
insight
about
progression
pregnancy
valuable
information
normal
developmental
trajectory
fetus.
The
current
limitations
using
bulk
RNA-sequencing
(RNA-seq)
analysis
stem
from
diverse
composition
placenta,
hindering
comprehensive
description
how
distinct
trophoblast
cell
expression
patterns
contribute
to
establishment
sustenance
successful
pregnancy.
At
present,
transcriptional
landscape
intricate
tissues
increasingly
relies
single-cell
RNA
sequencing
(scRNA-seq).
A
few
investigations
have
utilized
scRNA-seq
technology
examine
codes
governing
transcriptome
regulation
in
cells
at
maternal-fetal
interface.
In
this
review,
we
explore
fundamental
principles
technology,
offering
latest
overview
human
placental
studies
utilizing
method
across
various
gestational
weeks
both
pregnancies
pregnancy-related
diseases,
including
recurrent
loss
(RPL),
preeclampsia
(PE),
preterm
birth,
diabetes
mellitus
(GDM).
Furthermore,
discuss
future
perspectives
within
realm
reproduction.
It
seems
that
stands
out
as
one
crucial
tools
for
studying
etiology
complications.
direction
applications
may
involve
devolving
into
biology,
with
primary
focus
understanding
variations
activity
among
highly
specific
populations.
Our
goal
is
provide
obstetricians
an
updated
related
complications,
providing
understandings
aid
diagnosis
treatment
these
conditions,
ultimately
improving
maternal
fetal
prognosis.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 19, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
and
resulting
disease
(COVID-19)
causes
placental
dysfunction,
which
increases
the
risk
of
adverse
pregnancy
outcomes.
While
abnormal
pathology
from
COVID-19
is
common,
direct
placenta
rare.
This
suggests
that
pathophysiology
associated
with
maternal
COVID-19,
rather
than
infection,
responsible
for
dysfunction
alteration
transcriptome.
We
hypothesized
circulating
extracellular
vesicles
(EVs),
altered
by
during
pregnancy,
contribute
to
dysfunction.
To
examine
this
hypothesis,
we
characterized
EVs
pregnancies
complicated
tested
their
effects
on
trophoblast
cell
physiology
Epigenomics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 775 - 793
Published: May 6, 2024
Single-cell
sequencing
technologies
enhance
our
understanding
of
cellular
dynamics
throughout
pregnancy.
We
outlined
the
workflow
single-cell
techniques
and
reviewed
studies
in
maternal
child
health.
conducted
a
literature
review
single
cell
on
health
using
PubMed.
summarized
findings
from
16
atlases
human
mammalian
placenta
across
gestational
stages
31
exposures
complications
including
infection,
obesity,
diet,
diabetes,
pre-eclampsia,
environmental
exposure
preterm
birth.
provides
insights
novel
types
type-specific
marks
associated
with
complications.
FASEB BioAdvances,
Journal Year:
2024,
Volume and Issue:
6(11), P. 503 - 518
Published: Sept. 21, 2024
The
human
placenta
is
a
vital
organ,
encompassing
many
distinct
cell
types,
that
maintains
the
growth
and
development
of
fetus
essential
for
substance
exchange,
defense,
synthesis,
immunity.
Abnormalities
in
placental
cells
can
lead
to
various
pregnancy
complications,
but
mechanisms
remain
largely
unclear.
Single-cell
spatial
transcriptomics
technologies
have
been
developed
recent
years
demonstrate
heterogeneity
molecular
localization.
Here,
we
review
summarize
current
literature,
demonstrating
these
showing
cell-cell
communication
normal
placenta,
as
well
placenta-related
diseases,
such
preeclampsia,
gestational
diabetes
mellitus,
advanced
maternal
age,
recurrent
loss,
accreta
spectrum
disorders.
Meanwhile,
weaknesses
future
direction
were
discussed.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 9, 2024
Reproductive
success
hinges
on
the
presence
of
a
robust
and
functional
placenta.
Examining
placenta
provides
insight
about
progression
pregnancy
valuable
information
normal
developmental
trajectory
fetus.
The
current
limitations
using
bulk
RNA-sequencing
(RNA-seq)
analysis
stem
from
diverse
composition
placenta,
hindering
comprehensive
description
how
distinct
trophoblast
cell
expression
patterns
contribute
to
establishment
sustenance
successful
pregnancy.
At
present,
transcriptional
landscape
intricate
tissues
increasingly
relies
single-cell
RNA
sequencing
(scRNA-seq).
A
few
investigations
have
utilized
scRNA-seq
technology
examine
codes
governing
transcriptome
regulation
in
cells
at
maternal-fetal
interface.
In
this
review,
we
explore
fundamental
principles
technology,
offering
latest
overview
human
placental
studies
utilizing
method
across
various
gestational
weeks
both
pregnancies
pregnancy-related
diseases,
including
recurrent
loss
(RPL),
preeclampsia
(PE),
preterm
birth,
diabetes
mellitus
(GDM).
Furthermore,
discuss
future
perspectives
within
realm
reproduction.
It
seems
that
stands
out
as
one
crucial
tools
for
studying
etiology
complications.
direction
applications
may
involve
devolving
into
biology,
with
primary
focus
understanding
variations
activity
among
highly
specific
populations.
Our
goal
is
provide
obstetricians
an
updated
related
complications,
providing
understandings
aid
diagnosis
treatment
these
conditions,
ultimately
improving
maternal
fetal
prognosis.
