Glial Cell Reprogramming in Ischemic Stroke: A Review of Recent Advancements and Translational Challenges

Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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Single-cell RNA sequencing provides new insights into the interaction between astrocytes and neurons after spinal cord injury in mice

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101917 - 101917

Published: Jan. 18, 2025

Language: Английский

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Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2913 - 2913

Published: Oct. 27, 2023

Chemical transdifferentiation is a technique that utilizes small molecules to directly convert one cell type into another without passing through an intermediate stem state. This offers several advantages over other methods of reprogramming, such as simplicity, standardization, versatility, no ethical and safety concern patient-specific therapies. has been successfully applied various types across different tissues organs, its potential applications are rapidly expanding scientists continue explore new combinations refine the mechanisms driving fate conversion. These have opened up possibilities for regenerative medicine, disease modeling, drug discovery tissue engineering. However, there still challenges limitations need be overcome before chemical can translated clinical practice. include low efficiency reproducibility, incomplete understanding molecular mechanisms, long-term stability functionality transdifferentiated cells, cell-type specificity scalability. In this review, we compared commonly used in recent years discussed current progress future perspective somatic cells impact on biomedicine. We believe with ongoing research technological advancements, holds tremendous promise harnessing power shape cellular landscape revolutionize field

Language: Английский

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Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 3, 2024

Abstract Promising therapeutic strategies are being explored to replace or regenerate the neuronal populations that lost in patients with neurodegenerative disorders. Several research groups have attempted direct reprogramming of astrocytes into neurons by manipulating expression polypyrimidine tract-binding protein 1 (PTBP1) and claimed putative converted be functional, which led improved disease outcomes animal models several However, a few other studies reported data contradict these claims, raising doubt about whether PTBP1 suppression truly reprograms potential this approach. This review discusses recent advances regenerative therapeutics including stem cell transplantations for central nervous system disorders, particular focus on Parkinson’s Alzheimer’s diseases. We also provide perspective controversy considering astrocyte heterogeneity may key understanding discrepancy published studies, certain subpopulations glial cells more readily neurons.

Language: Английский

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Advances in neuronal reprogramming for neurodegenerative diseases: Strategies, controversies, and opportunities

Experimental Neurology, Journal Year: 2024, Volume and Issue: 378, P. 114817 - 114817

Published: May 17, 2024

Language: Английский

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