Could Urinary Amino Acids Be as New Biomarkers for Detection of Sarcopenia? DOI Creative Commons
Rıdvan Sivritepe, Sema Basat, Neslihan Gökmen İnan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background Sarcopenia is one of the syndromes that cause falls, fractures, and morbidity in geriatric patients. Early diagnosis sarcopenia important as it known muscle functions improve with early intervention. We aimed to investigate whether urinary amino acid levels are a biomarker sarcopenia. Methods The study included ninety-one patients aged 45–65 who applied our outpatient clinic. underwent physical examinations, blood tests sixteen different urine were analyzed. Anthropometric measurements made. Physical performances evaluated. Muscle strengths measured. masses Patients divided into 4 groups: pre-sarcopenic, sarcopenic, severe sarcopenic non-sarcopenic. Statistical significance level was determined p < 0.05. Results A total patients, fifty-three female thirty-eight males, study. Three had pre-sarcopenia, eleven sarcopenia, two met criteria for while seventy-five non sarcopenic. significant difference found between non-sarcopenia groups terms glutamine valine (p 0.001 both). In ROC analysis, cut-off value detecting 492 micromole/L 209 (AUC:0.875;0.968 respectively). correlation analysis strength-mass negative leucine strength mass. Conclusions high associated both

Language: Английский

Could Urinary Amino Acids Be as New Biomarkers for Detection of Sarcopenia? DOI Creative Commons
Rıdvan Sivritepe, Sema Basat, Neslihan Gökmen İnan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background Sarcopenia is one of the syndromes that cause falls, fractures, and morbidity in geriatric patients. Early diagnosis sarcopenia important as it known muscle functions improve with early intervention. We aimed to investigate whether urinary amino acid levels are a biomarker sarcopenia. Methods The study included ninety-one patients aged 45–65 who applied our outpatient clinic. underwent physical examinations, blood tests sixteen different urine were analyzed. Anthropometric measurements made. Physical performances evaluated. Muscle strengths measured. masses Patients divided into 4 groups: pre-sarcopenic, sarcopenic, severe sarcopenic non-sarcopenic. Statistical significance level was determined p < 0.05. Results A total patients, fifty-three female thirty-eight males, study. Three had pre-sarcopenia, eleven sarcopenia, two met criteria for while seventy-five non sarcopenic. significant difference found between non-sarcopenia groups terms glutamine valine (p 0.001 both). In ROC analysis, cut-off value detecting 492 micromole/L 209 (AUC:0.875;0.968 respectively). correlation analysis strength-mass negative leucine strength mass. Conclusions high associated both

Language: Английский

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