Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications

General Psychiatry, Journal Year: 2024, Volume and Issue: 37(1), P. e101374 - e101374

Published: Feb. 1, 2024

The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing microbiota-gut-brain axis, its metabolites regulate central nervous system through neural, endocrine immune pathways to ensure normal functioning of organism, tuning individuals’ health disease status. Short-chain fatty acids (SCFAs), main bioactive microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component axis In present review, roles major (acetate, propionate butyrate) pathophysiology depression summarised with respect chronic cerebral hypoperfusion, neuroinflammation, host epigenome neuroendocrine alterations. Concluding remarks biological mechanisms related will hopefully address clinical value microbiota-related treatments for

Language: Английский

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Effects of dietary fibre on metabolic health and obesity

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(5), P. 301 - 318

Published: Feb. 7, 2024

Language: Английский

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Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

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Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122815 - 122815

Published: June 11, 2024

Language: Английский

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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

The gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia Parkinson’s disease, represent substantial global health challenges. This review explores relationship between microbiota, modulation, decline, with particular focus gut-brain axis. Research indicates that bacteria produce metabolites, short-chain fatty acids (SCFAs), which affect mucosal immunity, antigen presentation, responses, thereby influencing A noteworthy correlation been identified imbalances in impairments, suggesting novel pathways for treatment disorders. Additionally, factors such diet, environment, pharmaceuticals play role shaping composition microbiome, subsequently impacting both health. article aims clarify complex interactions among regulation, evaluating their potential therapeutic targets. goal is promote microbiome-based treatments lay groundwork future this field.

Language: Английский

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Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer’s Disease Pathogenesis—From Gut Microbiota and Viruses to Brain Biofilms

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 90 - 90

Published: Jan. 5, 2025

For decades, Alzheimer's Disease (AD) research has focused on the amyloid cascade hypothesis, which identifies amyloid-beta (Aβ) as primary driver of disease. However, consistent failure Aβ-targeted therapies to demonstrate efficacy, coupled with significant safety concerns, underscores need rethink our approach AD treatment. Emerging evidence points microbial infections environmental factors in pathoetiology. Although a definitive causal link remains unestablished, collective is compelling. This review explores unconventional perspectives and emerging paradigms regarding involvement pathogenesis, emphasizing gut-brain axis, brain biofilms, oral microbiome, viral infections. Transgenic mouse models show that gut microbiota dysregulation precedes Aβ accumulation, signaling pathways. Viral like Herpes Simplex Virus Type 1 (HSV-1) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may lead by modulating host processes immune system. peptide's antimicrobial function response infection might inadvertently promote AD. We discuss potential microbiome-based promising strategies for managing potentially preventing progression. Fecal transplantation (FMT) restores balance, reduces improves cognition preclinical models. Probiotics prebiotics reduce neuroinflammation plaques, while antiviral targeting HSV-1 vaccines shingles vaccine mitigate pathology. Developing effective treatments requires standardized methods identify measure patients, enabling personalized address individual contributions pathogenesis. Further needed clarify interactions between microbes Aβ, explore bacterial interplay, understand their broader effects translate these insights into clinical interventions.

Language: Английский

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The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 386 - 386

Published: Jan. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Language: Английский

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Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347

Published: Jan. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Language: Английский

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Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102689 - 102689

Published: Feb. 1, 2025

Language: Английский

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The Role of Short-Chain Fatty Acids in Microbiota–Gut–Brain Cross-Talk with a Focus on Amyotrophic Lateral Sclerosis: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15094 - 15094

Published: Oct. 11, 2023

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease characterized by the gradual loss of motor neurons in brain and spinal cord, leading to progressive function decline. Unfortunately, there no effective treatment, its increasing prevalence linked an aging population, improved diagnostics, heightened awareness, changing lifestyles. In gastrointestinal system, gut microbiota plays vital role producing metabolites, neurotransmitters, immune molecules. Short-chain fatty acids, interest for their potential health benefits, are influenced fiber- plant-based diet, promoting diverse balanced microbiome. These acids impact body binding receptors on enteroendocrine cells, influencing hormones like glucagon-like peptide-1 peptide YY, which regulate appetite insulin sensitivity. Furthermore, these blood-brain barrier, neurotransmitter levels, neurotrophic factors, directly stimulate vagal afferent nerves, affecting gut-brain communication. The vagus nerve crucial link between brain, transmitting signals related appetite, inflammation, various processes. Dysregulation this pathway can contribute conditions obesity irritable bowel syndrome. Emerging evidence suggests complex interplay among microbiota, environmental factors influences processes via interconnected pathways, including function, anti-inflammation, energy metabolism. Embracing balanced, fiber-rich diet may foster microbiome, potentially impacting risk. Comprehensive understanding requires further research into interventions targeting microbiome acid production therapeutic neurodegeneration.

Language: Английский

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