Role of orphan G-protein coupled receptors in tissue ischemia: A comprehensive review
European Journal of Pharmacology,
Journal Year:
2024,
Volume and Issue:
978, P. 176762 - 176762
Published: June 19, 2024
Language: Английский
Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: go broad or go narrow?
Hala Kawa,
No information about this author
Zubair Ahmed,
No information about this author
Arshad Majid
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et al.
Neuropharmacology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 110192 - 110192
Published: Oct. 1, 2024
Language: Английский
Anwulignan Alleviates IRI by the Activation of Nrf2/HO-1 Signaling Pathway and Inhibiting NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis in Rats
Tissue and Cell,
Journal Year:
2025,
Volume and Issue:
93, P. 102775 - 102775
Published: Feb. 6, 2025
Language: Английский
Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype
Neurochemistry International,
Journal Year:
2024,
Volume and Issue:
178, P. 105795 - 105795
Published: June 20, 2024
Language: Английский
Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(4), P. 3353 - 3363
Published: April 12, 2024
Donation
after
circulatory
death
(DCD)
is
a
promising
strategy
for
alleviating
donor
shortage
in
heart
transplantation.
Trehalose,
an
autophagy
inducer,
has
been
shown
to
be
cardioprotective
ischemia-reperfusion
(IR)
model;
however,
its
role
IR
injury
DCD
remains
unknown.
In
the
present
study,
we
evaluated
effects
of
trehalose
on
cardiomyocyte
viability
and
activation
model.
model,
cardiomyocytes
(H9C2)
were
exposed
1
h
warm
ischemia,
cold
reperfusion.
Trehalose
was
administered
before
ischemia
(preconditioning),
during
or
Cell
measured
using
Counting
Kit-8
treatment
with
trehalose.
Autophagy
by
measuring
flux
inhibitor,
chloroquine,
microtubule-associated
protein
1A/1B
light
chain
3
B
(LC3)-II
western
blotting.
ischemic
period
(trehalose
preconditioning)
increased
cell
viability.
The
protective
preconditioning
negated
chloroquine
treatment.
Furthermore,
flux.
through
which
could
prevention
damage
Language: Английский
Early Detection of Pressure Ulcers: Considering Dynamic Phenomena and Temperature
Nicolas Gillard,
No information about this author
P. Coignard,
No information about this author
J. Kerdraon
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et al.
2021 International Conference on Computational Science and Computational Intelligence (CSCI),
Journal Year:
2023,
Volume and Issue:
unknown, P. 1503 - 1506
Published: Dec. 13, 2023
Language: Английский
MECHANISMS OF VASOPROTECTION AND CARDIOPROTECTION IN HYPOXYTHERAPY OF ARTERIAL HYPERTENSION AND CORONARY ARTERY DISEASE
Г. А. Игнатенко
No information about this author
Complex Issues of Cardiovascular Diseases,
Journal Year:
2024,
Volume and Issue:
13(1), P. 98 - 108
Published: March 29, 2024
Highlights
The
article
presents
a
modern
understanding
of
the
main
links
functional
circulatory
regulation
system
and
its
response
to
exogenous
hypoxia,
as
well
describes
data
available
on
molecular
mechanisms
vasoprotection
cardioprotection
involved
in
hypoxytherapy
patients
with
arterial
hypertension
coronary
artery
disease.
Abstract
Hypoxic
conditioning
has
taken
an
important
place
range
non-drug
methods
for
stimulating
adaptive
potential
healthy
person
cardiovascular
diseases.
There
are
many
approaches
use
various
however,
there
is
no
consensus
essence
sanogenetic
that
provide
multi-level
maintaining
oxygen
supply
blood
circulation.
Adaptive
reactions
afferent,
central
efferent
hypoxia
described.
results
studies
physiological
systemic
realized
by
respiratory
vegetative
plasticity
using
interval
(intermittent)
presented.
In
disease,
facts
chemoreflective
stimulation
modulation
lung
ventilation,
autonomic
nervous
status,
especially
sympathetic
activity
peripheral
vessels
vagal
activation
cardiac
have
been
established.
vaso-
cardioprotective
properties
based
leveling
oxidative
stress,
inflammation,
angiogenesis,
shift
secretory
endothelium
towards
vasodilating,
antiproliferative,
antithrombotic
mediators.
We
present
evidence
role
shear
stress
state
glycocalyx,
angiopoietin
adrenomedulline
vascular
tone,
cytoprotective
cytoplasmic
mitochondrial
metabolic
factors
formation
ischemic
tolerance
cardiomyocytes.
issues
relationship
between
(neuronal
humoral)
structural
responses
target
cells
providing
adaptive/compensatory
regulating
circulation
under
influence
require
further
research
evaluation.
Language: Английский
Clinical usage of ischemic tolerance-where are its limits?
Asian Journal of Surgery,
Journal Year:
2024,
Volume and Issue:
47(11), P. 4674 - 4680
Published: May 31, 2024
Ischemic
tolerance
is
a
robust
internal
defense
mechanism
of
all
living
organisms.
The
effectiveness
this
has
been
repeatedly
demonstrated
in
experiments,
but
comprehensive
review
the
clinical
applicability
phenomenon
practice
not
yet
published.
results
sound
ambiguous
and
unconvincing
comparison
with
experimental
studies.
Also,
many
localities,
effect
ischemic
was
clinically
proven.
For
reasons
mentioned,
authors
analyze
possible
causes
mentioned
discrepancies
provide
insight
into
relevant
use
for
different
groups
patients.
Language: Английский