Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery

Life Sciences, Journal Year: 2025, Volume and Issue: 368, P. 123499 - 123499

Published: Feb. 22, 2025

Language: Английский

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Medicinal Plant Extracts Targeting UV-Induced Skin Damage: Molecular Mechanisms and Therapeutic Potential

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2278 - 2278

Published: March 4, 2025

The depletion of the ozone layer has intensified ultraviolet (UV) radiation exposure, leading to oxidative stress, DNA damage, inflammation, photoaging, and skin cancer. Medicinal plants, widely used in Traditional Herbal Medicine (THM), particularly Chinese (TCM), have demonstrated significant therapeutic potential due their well-characterized active compounds established photoprotective effects. This review systematically evaluates 18 medicinal plants selected based on traditional use skin-related conditions emerging evidence supporting efficacy against UV-induced damage. Their bioactive components exert antioxidant, anti-inflammatory, repair, depigmentation effects by modulating key signaling pathways, including Nrf2/ARE-, MAPK/AP-1-, PI3K/Akt-, MITF/TYR-related melanogenesis pathways. Moreover, novel drug delivery systems, such as exosomes, hydrogels, nanoemulsions, significantly enhanced stability, bioavailability, penetration these compounds. However, challenges remain standardizing plant-derived formulations, elucidating complex synergistic mechanisms, translating preclinical findings into clinical applications. Future interdisciplinary research technological advancements will be essential harness full for damage prevention treatment.

Language: Английский

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Nanomanaging Chronic Wounds with Targeted Exosome Therapeutics

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 366 - 366

Published: March 13, 2025

Chronic wounds pose a significant healthcare challenge, impacting millions of patients worldwide and burdening systems substantially. These often occur as comorbidities are prone to infections. Such infections hinder the healing process, complicating clinical management proving recalcitrant therapy. The environment within wound itself poses challenges such lack oxygen, restricted blood flow, oxidative stress, ongoing inflammation, bacterial presence. Traditional systemic treatment for chronic peripheral may not be effective due inadequate supply, resulting in unintended side effects. Furthermore, topical applications impervious persistent biofilm A growing concern is therapeutic modalities treating wounds. Additionally, chemically harsh microenvironment can reduce effectiveness treatments, highlighting need drug delivery that deliver therapies precisely where needed with optimal dosages. Compared cell-based therapies, exosome-based offer distinct advantages cell-free approach treatment. Exosomes endosomal origin enable cell-to-cell communications, they possess benefits, including biocompatibility decreased immunogenicity, making them ideal vehicles efficient targeting minimizing off-target damage. However, exosomes rapidly cleared from body, it difficult maintain concentrations at sites. hydrogel-based development biocompatible scaffolds beneficial sustained release prolong presence these Engineered have been shown stability promoting compared their unmodified counterparts. Significant progress has made this field, but further research essential unlock potential. This review seeks explore benefits opportunities wounds, ensuring efficacy precise despite obstacles posed by environment.

Language: Английский

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Cartilage-targeting Exosomes for Delivery of Receptor Antagonist of Interleukin-1 in Osteoarthritis treatment

Osteoarthritis and Cartilage, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Optimization of exosome-based cell-free strategies to enhance endogenous cell functions in tissue regeneration

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 171, P. 68 - 84

Published: Sept. 19, 2023

Language: Английский

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