Cureus,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 7, 2023
Peritoneal
adhesions
are
an
unwanted
and
frequent
event
following
abdominal
surgery,
with
a
response
rate
that
can
reach
100%.
The
be
symptomatic,
becoming
source
of
pain
discomfort
for
the
patient,
or
asymptomatic,
possible
chronic
acute
visceral
dysfunction.
article
reviews
what
diagnostic
strategies
discusses
could
causes
lead
to
in
presence
adhesions.
text
reports
knowledge
literature
on
manual
treatment
illustrates
symptoms
not
easily
recognized
by
clinician.
To
conclude,
proposes
osteopathic
approaches
derived
from
clinical
experience
has
been
explained
about
formation
peritoneal
Research
must
make
further
efforts
identify
only
triggering
neogenesis
but
also
seek
most
appropriate
non-invasive
treatments
help
patient.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(2)
Published: Feb. 1, 2025
ABSTRACT
Clinical
studies
have
revealed
a
significant
correlation
between
pain
and
neurodegenerative
diseases,
particularly
Alzheimer's
disease
(AD).
However,
due
to
cognitive
speech
impairments,
AD
patients,
especially
those
in
moderate
severe
stages,
are
often
overlooked
management.
The
challenges
obtaining
pain‐related
information
from
this
population
exacerbate
the
issue.
Although
recent
clinical
research
has
increasingly
recognized
comorbidity
of
pain,
pathological
alterations
interactive
mechanisms
underlying
relationship
remain
inadequately
explored.
This
review
provides
comprehensive
analysis
features
with
without
comorbidity.
It
examines
processes,
including
neuroinflammation,
peripheral‐central
immune
interactions,
neurotransmitter
dynamics.
Furthermore,
it
highlights
current
assessment
management
strategies
patients.
By
offering
theoretical
framework,
aims
support
development
effective
approaches
serve
as
reference
for
interventions
targeting
AD‐associated
pain.
Highlights
CP
encompasses
multiple
interrelated
biological
pathways,
such
neurodegeneration
inflammatory
responses.
damage
neurons
synapses
patients
influences
brain
regions
responsible
processing
thereby
reducing
response.
Neuroinflammation
plays
vital
role
both
CP.
Enhanced
responses
an
impact
on
CNS
promote
sensitization.
Common
exist
CP,
influencing
cognition,
emotion,
perception.
Biochemical Pharmacology,
Journal Year:
2024,
Volume and Issue:
228, P. 116182 - 116182
Published: March 30, 2024
Osteoarthritis
(OA)
is
the
most
common
form
of
musculoskeletal
disease,
and
its
prevalence
increasing
due
to
aging
population.
Chronic
pain
burdensome
symptom
OA
that
significantly
lowers
patients'
quality
life,
also
frequent
association
with
emotional
comorbidities,
such
as
anxiety
depression.
In
recent
years,
both
chronic
mood
alterations
have
been
linked
development
neuroinflammation
in
peripheral
nervous
system,
spinal
cord
supraspinal
brain
areas.
Thus,
mechanisms
at
basis
neuroinflammatory
process
may
indicate
promising
targets
for
novel
treatment
affective
comorbidities
accompany
OA.
order
assess
key
role
maintenance
potential
involvement
psychiatric
components,
monoiodoacetate
(MIA)
model
rodents
has
used
validated.
present
commentary
article,
we
aim
summarize
up-to-date
results
achieved
this
experimental
OA,
focusing
on
glia
activation
cytokine
production
sciatic
nerve,
dorsal
root
ganglia
(DRGs),
The
a
state
anxiety-
depression-like
behaviors
are
discussed.
Results
suggest
cells
molecules
involved
represent
innovative
pharmacological
treatments
comorbidities.
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
193, P. 106443 - 106443
Published: Feb. 21, 2024
The
coexistence
of
chronic
pain
and
depression
in
clinical
practice
places
a
substantial
social
burden
profoundly
impacts
patients.
Although
clear
correlation
exists,
the
underlying
mechanism
comorbidity
between
remains
elusive.
Research
conducted
recent
decades
has
uncovered
that
soluble
epoxide
hydrolase,
pivotal
enzyme
metabolism
polyunsaturated
fatty
acids,
plays
crucial
role
inflammation.
Interestingly,
this
is
intricately
linked
to
development
both
depression.
With
understanding,
review
aims
summarize
roles
hydrolase
pain,
depression,
their
comorbidity.
Simultaneously,
we
will
also
explore
mechanisms,
providing
guidance
for
future
research
drug
development.
Inflammopharmacology,
Journal Year:
2024,
Volume and Issue:
32(5), P. 3357 - 3373
Published: July 2, 2024
Previous
observational
studies
have
indicated
a
complex
association
between
gut
microbiota
(GM)
and
neuropathic
pain
(NP).
Nonetheless,
the
precise
biological
mechanisms
underlying
this
remain
unclear.
Therefore,
we
adopted
Mendelian
randomization
(MR)
approach
to
investigate
causal
relationship
GM
including
post-herpetic
neuralgia
(PHN),
painful
diabetic
peripheral
neuropathy
(PDPN),
trigeminal
(TN),
as
well
explore
potential
mediation
effects
of
immune
cells.
International Journal of Food Science & Technology,
Journal Year:
2024,
Volume and Issue:
59(9), P. 5902 - 5911
Published: July 31, 2024
Summary
Short‐chain
fatty
acids
(SCFAs)
hold
exert
many
nutritional
benefits
on
both
physiological
and
pathological
processes,
including
host
metabolism,
immune
modulation,
appetite
control.
Originating
from
the
microbial
fermentation
of
resistant
starches
dietary
fibre
in
colon,
SCFAs
have
capability
to
traverse
blood–brain
barrier
(BBB).
It
is
evident
that
play
a
critical
role
development
neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD).
AD
most
common
form
dementia
characterised
by
deposition
amyloid
β
peptides
(Aβ)
tau
hyperphosphorylation.
demonstrated
potential
interfere
with
protein–protein
interactions
required
for
Aβ
neurotoxic
oligomers.
Moreover,
research
indicates
ability
maintain
endothelial
integrity
interact
neuroglial
cells
through
BBB
may
assist
downregulating
excessive
neuroinflammatory
responses
peptides.
This
review
summarises
SCFAs'
understand
their
mechanism
actions
astrocytes
microglia.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 30, 2024
There
are
few
efficient
treatment
options
for
alcohol
addiction,
which
continues
to
be
a
serious
public
health
concern.
The
possible
contribution
of
gut
microbiota
the
onset
and
progression
addiction
has
been
brought
light
by
recent
studies.
Probiotics
have
become
cutting-edge
intervention
in
consumption
disorder
because
its
favorable
effects
on
health.
purpose
this
systematic
review
is
assess
body
research
advantages
probiotics
treating
alcoholism
associated
neuroinflammatory
conditions.
