Bulletin of Experimental Biology and Medicine, Journal Year: 2024, Volume and Issue: 178(2), P. 223 - 226
Published: Dec. 1, 2024
Language: Английский
Citations
1Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration Within the One Health Approach
Published: Nov. 13, 2023
This comprehensive review elucidates the profound relationship between human microbiome and breast cancer managrement. Recent findings highlight significance of microbial alterations in tissues, such as gut breast, their role influencing risk, development, progression, treatment outcomes. We delve into how can modulate systemic inflammatory responses estrogen levels, thereby impacting initiation therapeutic drug efficacy. Furthermore, we explore unique diversity within tissue, indicating potential imbalances brought about by highlighting specific microbes promising targets. Emphasizing a holistic One Health approach, this underscores importance integrating insights from human, animal, environmental health to gain deeper understanding complex microbe-cancer interplay. As field advances, strategic manipulation its metabolites presents innovative prospects for enhancing diagnostics therapeutics. However, rigorous clinical trials remain essential confirm microbiota-based interventions management.
Language: Английский
Citations
3Multiomics insights on the onset, progression, and metastatic evolution of breast cancer
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: Dec. 19, 2023
Breast cancer is the most common malignant neoplasm in women. Despite progress to date, 700,000 women worldwide died of this disease 2020. Apparently, prognostic markers currently used clinic are not sufficient determine appropriate treatment. For reason, great efforts have been made recent years identify new molecular biomarkers that will allow more precise and personalized therapeutic decisions both primary recurrent breast cancers. These include genetic post-transcriptional alterations, changes protein expression, as well metabolic, immunological or microbial identified by multiple omics technologies (e.g., genomics, epigenomics, transcriptomics, proteomics, glycomics, metabolomics, lipidomics, immunomics microbiomics). This review summarizes studies based on analysis for diagnosis, patient stratification, differentiation between stages tumor development (initiation, progression, metastasis/recurrence), their relevance treatment selection. Furthermore, highlights importance clinical trials multiomics need advance direction order establish therapies prolong disease-free survival these patients future.
Language: Английский
Citations
3Bibliometric analysis of global research trends between gut microbiota and breast cancer: from 2013 to 2023
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 31, 2024
Background Breast cancer is the most prevalent globally and associated with significant mortality. Recent research has provided crucial insights into role of gut microbiota in onset progression breast cancer, confirming its impact on disease’s management. Despite numerous studies exploring this relationship, there a lack comprehensive bibliometric analyses to outline field’s current state emerging trends. This study aims fill that gap by analyzing key directions identifying hotspots. Method Publications from 2013 2023 were retrieved Web Science Core Collection database. The VOSviewer, R language SCImago Graphica software utilized analyze visualize volume publications, countries/regions, institutions, authors, keywords field. Results A total 515 publications included study. journal Cancers was identified as prolific, contributing 21 papers. United States China leading contributors University Alabama at Birmingham productive institution. Peter Bai published papers, while James J. Goedert cited author. Analysis highly literature keyword clustering confirmed close relationship between cancer. Keywords such “metabolomics” “probiotics” have been prominently highlighted analysis, indicating future hotspots interaction metabolites microenvironment microbiota. Additionally, these suggest interest therapeutic potential probiotics for treatment. Conclusion Research expanding. Attention should be focused understanding mechanisms their interaction, particularly metabolite-microbiota-breast crosstalk. These advance prevention, diagnosis, treatment strategies provides assessment trends field, offering valuable perspectives
Language: Английский
Citations
0Bacteria and Cancer
Published: Jan. 1, 2024
Language: Английский
Citations
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