Increased DNA Damage of Adipose Tissue-Derived Mesenchymal Stem Cells Under Inflammatory Conditions DOI Creative Commons
Zoltán G. Páhi, Diána Szűcs,

Vanda Miklós

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36275 - e36275

Published: Aug. 23, 2024

Cells have evolved various DNA repair mechanisms to prevent damage from building up. Malfunctions during can influence cellular homeostasis because they bring on genomic instability through the improper recognition of or dysregulation process. Maintaining proper is also essential for stem cells (SCs), as provide a differentiated cell population living organism. SCs are regularly used in personalized therapy. Patients must be treated with specific activators produce these effectively. This report investigated impact treating mesenchymal (MSC) lipopolysaccharide, tumor necrosis factor, interferon-gamma, polyinosinic acid, interleukin 1 beta, while monitoring their transcription-related response using next-generation sequencing. RNA sequencing revealed robust gene expression changes, including those genes encoding proteins implicated response. Stem effectively damages; moreover, fail undergo senescence death when genetic lesions accumulate. Here, we draw attention an elevated activation following MSC induction, which may main reason ineffective transplantation and contribute drift that initiate formation.Graphical abstract

Language: Английский

The Metabolic Syndrome, a Human Disease DOI Open Access
M. Alemany

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

Citations

32
Advancements in innate immune regulation strategies in islet transplantation DOI Creative Commons

Kehang Duan,

Jiao Liu, Jian Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 15, 2024

As a newly emerging organ transplantation technique, islet has shown the advantages of minimal trauma and high safety since it was first carried out. The proposal Edmonton protocol, which been widely applied, breakthrough in this method. However, direct contact between islets portal vein blood will cause robust innate immune response leading to massive apoptosis graft, macrophages play an essential role response. Therefore, therapeutic strategies targeting have become popular research topic recent years. This paper summarize analyze on for regulating immunity, primarily focusing macrophages, field transplantation, including drug therapy, optimization preparation process, engineering Mesenchymal stem cells cotransplantation. We also expounded heterogeneity, plasticity activation mechanism providing theoretical basis further research.

Language: Английский

Citations

5
Licensing effects of inflammatory factors and TLR ligands on the regenerative capacity of adipose-derived mesenchymal stem cells DOI Creative Commons
Diána Szűcs, Tamás Monostori,

Vanda Miklós

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 28, 2024

Introduction: Adipose tissue-derived mesenchymal stem cells are promising contributors to regenerative medicine, exhibiting the ability regenerate tissues and modulate immune system, which is particularly beneficial for addressing chronic inflammatory ulcers wounds. Despite their inherent capabilities, research suggests that pretreatment amplifies therapeutic effectiveness. Methods: Our experimental design exposed adipose-derived six factors 24 h. We subsequently evaluated gene expression proteome profile alterations observed wound closure rate post-treatment. Results: Specific pretreatments, such as IL‐1β, notably demonstrated an accelerated wound‐healing process. Analysis of protein profiles revealed in pathways associated with tissue regeneration. Discussion: This licensed exhibit potentially higher efficiency than untreated cells, shedding light on optimizing strategies using adipose cells.

Language: Английский

Citations

2
Cell Origin and Microenvironment: The Players of Differentiation Capacity in Human Mesenchymal Stem Cells DOI
Seyed Mehdi Hoseini, Fateme Montazeri

Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102709 - 102709

Published: Dec. 31, 2024

Language: Английский

Citations

2
Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications DOI Creative Commons

Xu-huan Li,

Han-xi Xiao,

Zu-xiu Wang

et al.

Cell Transplantation, Journal Year: 2024, Volume and Issue: 33

Published: Jan. 1, 2024

This article presents a comprehensive review of the factors influencing efficacy mesenchymal stem cells (MSCs) transplantation and its association with platelet concentrates (PCs). It focuses on investigating impact PCs’ composition, age health status donors, application methods, environmental outcomes relevant treatments. In addition, it delves into strategies mechanisms for optimizing MSCs PCs, encompassing preconditioning combined therapies. Furthermore, provides an in-depth exploration signaling pathways proteomic characteristics associated emphasizes specific effects therapy. The also introduces latest advancements in biomaterials regenerative medical strategies, stimulating scholarly discourse this subject. Through review, primary goal is to facilitate more profound comprehension treatment outcomes, as well medicine, offering theoretical guidance practical references related research clinical practice.

Language: Английский

Citations

1
Mesenchymal stem cell-based therapy for paraquat-induced lung injury DOI Creative Commons

Xiaping Zhang,

Ting Li, Yuan‐Qiang Lu

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Aug. 13, 2024

Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective repairing the injured lung tissues. Recent research has highlighted promise of using stem cell therapy, namely mesenchymal cells, as a new method for treating paraquat toxicity. These cells have shown effectiveness decreasing inflammation, apoptosis, and fibrosis mice lungs subjected to paraquat. The therapeutic implications believed arise from their release bioactive proteins capacity regulate inflammatory responses. However, additional clinical study is required validate these therapies' efficacy. This review thoroughly explores pathophysiology properties cells. Additionally, it critically assesses long-term safety therapies, which crucial developing more dependable treatment protocols. In summary, although offer promising prospects injuries, investigations optimize ensure safe application context poisoning.

Language: Английский

Citations

1
Increased DNA Damage of Adipose Tissue-Derived Mesenchymal Stem Cells Under Inflammatory Conditions DOI Creative Commons
Zoltán G. Páhi, Diána Szűcs,

Vanda Miklós

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36275 - e36275

Published: Aug. 23, 2024

Cells have evolved various DNA repair mechanisms to prevent damage from building up. Malfunctions during can influence cellular homeostasis because they bring on genomic instability through the improper recognition of or dysregulation process. Maintaining proper is also essential for stem cells (SCs), as provide a differentiated cell population living organism. SCs are regularly used in personalized therapy. Patients must be treated with specific activators produce these effectively. This report investigated impact treating mesenchymal (MSC) lipopolysaccharide, tumor necrosis factor, interferon-gamma, polyinosinic acid, interleukin 1 beta, while monitoring their transcription-related response using next-generation sequencing. RNA sequencing revealed robust gene expression changes, including those genes encoding proteins implicated response. Stem effectively damages; moreover, fail undergo senescence death when genetic lesions accumulate. Here, we draw attention an elevated activation following MSC induction, which may main reason ineffective transplantation and contribute drift that initiate formation.Graphical abstract

Language: Английский

Citations

0