Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 24, 2024

Muscle loss is a significant health concern, particularly with the increasing trend of population aging, and sarcopenia has emerged as common pathological process muscle in elderly. Currently, there been progress research on sarcopenia, including in-depth analysis mechanisms underlying caused by aging development corresponding diagnostic criteria, forming relatively complete system. However, progresses, concept secondary also proposed. Due to incomplete understanding chronic diseases, are various limitations epidemiological, basic, clinical research. As result, comprehensive system have not yet established, which greatly hinders prevention treatment disease. This review focuses Type 2 Diabetes Mellitus (T2DM)-related comparing its similarities differences disuse atrophy. The show between three muscle-related issues terms changes, epidemiology manifestations, etiology, preventive therapeutic strategies. Unlike T2DM-related characterized reduction type I fibers, it differs from atrophy well. mechanism involving insulin resistance, inflammatory status, oxidative stress remains unclear. Therefore, future should further explore disease progression, prognosis develop targeted criteria effective strategies better address faced T2DM patients improve their quality life overall health.

Language: Английский

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17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

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Epigenetic factors and inflammaging: FOXO3A as a potential biomarker of sarcopenia and upregulation of DNMT3A and SIRT3 in older adults

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Background Epigenetic factors influence inflammaging and geriatric disorders such as sarcopenia frailty. It is necessary to develop a biomarker/panel of biomarkers for fast easy diagnostics. Currently, hard-to-access equipment required diagnose sarcopenia. The development will prevent many older adults from being excluded the diagnostic process. Methods In this study, we analyzed selected gene expression profiles, namely, SIRT1 , SIRT3 SIRT6 DNMT3A FOXO1 FOXO3A ELAVL1 in whole blood. study included 168 subjects divided into five groups: patients hospitalized at Geriatrics Clinic Polyclinic with sarcopenia, frailty syndrome, or without those (geriatric control), non-hospitalized healthy controls (HC) aged 25 30 years over 50 years. Results We revealed lower mRNA level (p<0.001) sarcopenic compared controls. Furthermore, detected upregulation (p=0.003) (p=0.015) HC old Interestingly, observed 2 cluster formations during correlation analysis ( ). also noted correlations clinical parameters levels group, vitamin D (r=0.64, p=0.010), creatine kinase (r=–0.58, p=0.032) (r=–0.59, p=0.026), creatinine (r=0.57, erythrocyte sedimentation rate (ESR) (r=0.69, p=0.004), lactate dehydrogenase (LDH) (r=–0.86, p=0.007). syndrome appendicular skeletal muscle mass (ASMM) (r=0.59, p=0.026) level. controls, serum iron (r=–0.79, p=0.036). Conclusions Our potential biomarker high epigenetic ) adults.

Language: Английский

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Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4673 - 4673

Published: May 14, 2025

Metabolic-Associated Fatty Liver Disease (MAFLD) is a public health concern that constantly expanding, with fast-growing prevalence, and it affects about quarter of the world's population. This condition significant risk factor for cardiovascular, hepatic, oncologic diseases, such as hypertension, hepatoma, atherosclerosis. Sarcopenia was long considered to be an aging-related syndrome, but today, acknowledged secondarily related chronic diseases metabolic cardiovascular conditions, liver among other comorbidities associated insulin resistance inflammation, besides inactivity poor nutrition. The physiopathology involving MAFLD sarcopenia has still not been solved. Inflammation, oxidative stress, mitochondrial dysfunction, seem some keys this relationship since hormone target mainly skeletal muscle. review aimed comprehensively discuss main physiological pathways involved in these conditions. are interconnected by complex network pathophysiological mechanisms, resistance, muscle tissue production capacity, inflammatory state, which contributors relationship. In addition, clinical analysis, patients manifest more severe hepatitis fibrosis when compared only MAFLD. These patients, both disorders, also present improvement their treated sarcopenia, reinforcing association between them. Lifestyle changes accompanied non-pharmacological interventions, dietary therapy increased physical activity, undoubtedly improve scenario.

Language: Английский

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Identification of Peucedanum japonicum Thunb. extract components and their protective effects against dexamethasone-induced muscle atrophy

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155449 - 155449

Published: Feb. 13, 2024

Language: Английский

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Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia

Cells, Journal Year: 2023, Volume and Issue: 12(22), P. 2608 - 2608

Published: Nov. 11, 2023

Sarcopenia is a disease characterized by the progressive loss of skeletal muscle mass and function that occurs with aging. The progression sarcopenia correlated onset physical disability, inability to live independently, increased mortality. Due global increases in lifespan demographic aging developed countries, has become major socioeconomic burden. Clinical therapies for are based on therapy nutritional support, although these may suffer from low adherence variable outcomes. There currently no clinically approved drugs sarcopenia. Consequently, there large amount pre-clinical research focusing discovering new candidate novel targets. In this review, recent progress will be discussed, along challenges preclude successful translational clinic. types examined include mitochondria-targeting compounds, anti-diabetes agents, small molecules target non-coding RNAs, protein therapeutics, natural products, repositioning candidates. light number targets being reported, it can envisioned pharmaceuticals prevent or even mitigate within reach.

Language: Английский

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SLC25 family with energy metabolism and immunity in malignant tumors

ONCOLOGIE, Journal Year: 2023, Volume and Issue: 26(1), P. 65 - 77

Published: Dec. 5, 2023

Abstract Solute Carrier Family 25 ( SLC25 ) is the largest family of mitochondrial membrane proteins in human body, consisting 53 members. Mitochondrial phosphate carriers (MPiC), cellular iron metabolism, voltage-dependent anion channels (VDAC), and oxidative phosphorylation play dominant roles material transport, energy etc. family-related are involved regulation progression a variety cancers, including colon, gastric, lung cancers. In addition, has been implicated endoplasmic reticulum stress (ERS) immunity. Since cancer associated with immunity, exploring inhibitors essential. However, exact mechanism cancer, as well potential targets have not reported literature. This article focuses on summarizing relevance to ERS, review also provides comprehensive overview inhibitors.

Language: Английский

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Insights into the Therapeutic Potential of Active Ingredients of Citri Reticulatae Pericarpium in Combatting Sarcopenia: An In Silico Approach

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11451 - 11451

Published: Oct. 25, 2024

Sarcopenia is a systemic medical disorder characterized by gradual decline in muscular strength, function, and skeletal muscle mass. Currently, there no medication specifically approved for the treatment of this condition. Therefore, identification new pharmacological targets may offer opportunities development novel therapeutic strategies. The current silico study investigated active ingredients mode action

Language: Английский

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The essential role of dual-energy x-ray absorptiometry in the prediction of subclinical cardiovascular disease

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 29, 2024

Subclinical cardiovascular disease (Sub-CVD) is an early stage of and often asymptomatic. Risk factors, including hypertension, diabetes, obesity, lifestyle, significantly affect Sub-CVD. Progress in imaging technology has facilitated the timely identification phenotypes risk categorization. The critical function dual-energy x-ray absorptiometry (DXA) predicting Sub-CVD was subject this research. Initially used to evaluate bone mineral density, DXA now evolved into indispensable tool for assessing body composition, which a pivotal determinant estimating risk. offers precise measurements fat, lean muscle mass, abdominal aortic calcification, rendering it essential evaluation. This study examined efficacy integrating various factors comprehensive assessment how application machine learning could enhance discovery control risks. exhibits distinct advantages constraints compared alternative modalities such as ultrasound, computed tomography, magnetic resonance imaging, positron emission tomography. review advocates incorporation health assessments, emphasizing its crucial role management

Language: Английский

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Fermented red ginseng extract improves sarcopenia-related muscle atrophy in old mice through regulation of muscle protein metabolism

Food Science and Biotechnology, Journal Year: 2024, Volume and Issue: 34(3), P. 793 - 802

Published: Sept. 23, 2024

Language: Английский

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