Long-term mortality in different COVID-19 variants: 18-month follow-up DOI Creative Commons
И. А. Лакман, Д. Ф. Гареева, L. F. Sadikova

et al.

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 28(12), P. 5672 - 5672

Published: Dec. 20, 2023

The viral infection and pandemic of coronavirus 2019 (COVID-19) was characterized not only by high morbidity in-hospital mortality, but also an increase in the mortality patients after hospital discharge. At same time, differences were noted hospitalization rate, number complications patients, rate between different waves from 2020 to 2023. Aim . To compare 18-month post-hospital three COVID-19 variants (Alpha, Delta Omicron). Material methods In this prospective, single-center, non-randomized continuous study, 2400 medical records with Alpha variant (2020), 1826 (2021) 997 Omicron (2022) analyzed. end point all-cause during follow-up period. Results There following clinical demographic characteristics context strains: more women hospitalized waves; wave, older. Also, comorbid common than (in chronic obstructive pulmonary disease, hypertension heart failure), kidney disease variants. groups differed significantly maximum being minimum Omicron, observed first 90 days Between 12 18 months, survival estimates decreased most for which is determined risk long-term cardiovascular consequences. Conclusion Clinical variants, as well a significant difference waves, emphasize importance personalized approach treatment monitoring.

Language: Английский

ACE2 and TMPRSS2 gene expression is reduced acutely in SARS-CoV-2 patients but returns to normal with recovery DOI Creative Commons

Vivien Chen,

Joshua K. Tay, Rijan Gurung

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 14, 2025

Language: Английский

Citations

0
Age-associated changes in the heart: implications for COVID-19 therapies DOI Creative Commons

Colby Wood,

Zach Saltera,

Irvin Jither Garcia

et al.

Aging, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Cardiac aging involves progressive structural, functional, cellular, and molecular changes that impair heart function. This review explores key mechanisms, including oxidative stress, mitochondrial dysfunction, impaired autophagy, chronic low-grade inflammation. Excess reactive oxygen species (ROS) damage muscle cells, contributing to fibrosis cellular aging. Mitochondrial dysfunction reduces energy production increases accelerating cardiac decline. Impaired autophagy limits the removal of damaged proteins organelles, while inflammation activates signaling molecules drive tissue remodeling. Gender differences reveal estrogen's protective role in premenopausal women, with men showing greater susceptibility injury. After menopause, women lose this hormonal protection, increasing their risk cardiovascular conditions. Ethnic disparities, particularly among underserved minority populations, emphasize how social factors such as access care, environment, stress contribute worsening outcomes. The coronavirus disease pandemic has introduced further challenges by incidence through inflammation, blood clots, long-term failure, especially older adults existing metabolic conditions like diabetes high pressure. virus's interaction receptors on vessel along a weakened immune response adults, intensifies Emerging therapies include delivery therapeutic extracellular vesicles, cell modulation, treatments targeting mitochondria. In addition, lifestyle strategies regular physical activity, nutritional improvements, reduction remain vital maintaining health. Understanding these biological intersect is critical developing targeted promote healthy heart.

Language: Английский

Citations

0
The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination DOI Creative Commons

Hannah L. Stimart,

Brittany Hipkins

Journal of Osteopathic Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.

Language: Английский

Citations

1
Elevated CRP and IL6 Levels Predict Severe Cardiovascular Outcomes in COVID-19 Patients DOI

Ali Abdel Moneim Mohammed Hussain Al Khuzaie,

Enas Abdul Kareem Jabbar, Bushra Jabbar Albadry

et al.

Academia Open, Journal Year: 2024, Volume and Issue: 9(2)

Published: May 17, 2024

This study explores the association between C-reactive protein (CRP) and interleukin 6 (IL-6) levels cardiovascular complications in COVID-19 patients. Utilizing an ELISA kit for IL-6 standard tests CRP, we analyzed 192 samples, finding higher infection rates among 50-69 age group, with significant prevalence of morbid obesity. Results showed a strong correlation elevated CRP severity complications, particularly critical cases. These findings suggest that monitoring these biomarkers could be crucial early intervention managing risks patients, potentially improving patient outcomes clinical settings. Highlights: Biomarker Correlation: Elevated are linked to severe Risk Management: Monitoring helps risks. Demographic Insights: The highest complication group Keywords: COVID-19, Cardiovascular Complications, IL-6,

Language: Английский

Citations

0
Long-term mortality in different COVID-19 variants: 18-month follow-up DOI Creative Commons
И. А. Лакман, Д. Ф. Гареева, L. F. Sadikova

et al.

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 28(12), P. 5672 - 5672

Published: Dec. 20, 2023

The viral infection and pandemic of coronavirus 2019 (COVID-19) was characterized not only by high morbidity in-hospital mortality, but also an increase in the mortality patients after hospital discharge. At same time, differences were noted hospitalization rate, number complications patients, rate between different waves from 2020 to 2023. Aim . To compare 18-month post-hospital three COVID-19 variants (Alpha, Delta Omicron). Material methods In this prospective, single-center, non-randomized continuous study, 2400 medical records with Alpha variant (2020), 1826 (2021) 997 Omicron (2022) analyzed. end point all-cause during follow-up period. Results There following clinical demographic characteristics context strains: more women hospitalized waves; wave, older. Also, comorbid common than (in chronic obstructive pulmonary disease, hypertension heart failure), kidney disease variants. groups differed significantly maximum being minimum Omicron, observed first 90 days Between 12 18 months, survival estimates decreased most for which is determined risk long-term cardiovascular consequences. Conclusion Clinical variants, as well a significant difference waves, emphasize importance personalized approach treatment monitoring.

Language: Английский

Citations

0