ACE2 and TMPRSS2 gene expression is reduced acutely in SARS-CoV-2 patients but returns to normal with recovery
Vivien Chen,
No information about this author
Joshua K. Tay,
No information about this author
Rijan Gurung
No information about this author
et al.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 14, 2025
Language: Английский
Age-associated changes in the heart: implications for COVID-19 therapies
Colby Wood,
No information about this author
Zach Saltera,
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Irvin Jither Garcia
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et al.
Aging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 13, 2025
Cardiac
aging
involves
progressive
structural,
functional,
cellular,
and
molecular
changes
that
impair
heart
function.
This
review
explores
key
mechanisms,
including
oxidative
stress,
mitochondrial
dysfunction,
impaired
autophagy,
chronic
low-grade
inflammation.
Excess
reactive
oxygen
species
(ROS)
damage
muscle
cells,
contributing
to
fibrosis
cellular
aging.
Mitochondrial
dysfunction
reduces
energy
production
increases
accelerating
cardiac
decline.
Impaired
autophagy
limits
the
removal
of
damaged
proteins
organelles,
while
inflammation
activates
signaling
molecules
drive
tissue
remodeling.
Gender
differences
reveal
estrogen's
protective
role
in
premenopausal
women,
with
men
showing
greater
susceptibility
injury.
After
menopause,
women
lose
this
hormonal
protection,
increasing
their
risk
cardiovascular
conditions.
Ethnic
disparities,
particularly
among
underserved
minority
populations,
emphasize
how
social
factors
such
as
access
care,
environment,
stress
contribute
worsening
outcomes.
The
coronavirus
disease
pandemic
has
introduced
further
challenges
by
incidence
through
inflammation,
blood
clots,
long-term
failure,
especially
older
adults
existing
metabolic
conditions
like
diabetes
high
pressure.
virus's
interaction
receptors
on
vessel
along
a
weakened
immune
response
adults,
intensifies
Emerging
therapies
include
delivery
therapeutic
extracellular
vesicles,
cell
modulation,
treatments
targeting
mitochondria.
In
addition,
lifestyle
strategies
regular
physical
activity,
nutritional
improvements,
reduction
remain
vital
maintaining
health.
Understanding
these
biological
intersect
is
critical
developing
targeted
promote
healthy
heart.
Language: Английский
The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination
Hannah L. Stimart,
No information about this author
Brittany Hipkins
No information about this author
Journal of Osteopathic Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
In
2019,
emergence
of
the
novel
and
communicable
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
took
scientific
communities
by
surprise
imposed
significant
burden
on
healthcare
systems
globally.
Although
advent
this
disease
piqued
interest
academic
centers,
systems,
general
public,
there
is
still
much
yet
to
be
elucidated
regarding
epidemiology,
pathophysiology,
long-term
impacts
2019
(COVID-19).
It
has
been
established
that
long
COVID-19
can
impact
multiple
organ
including
cardiovascular
system,
unfavorably.
pathophysiology
damage
not
well
understood,
adverse
sequelae
may
range
from
chest
pain
arrhythmias
heart
failure
(HF),
myocardial
infarction,
or
sudden
cardiac
death.
For
any
postacute
patient
requiring
a
surgical
procedure,
potential
for
injury
secondary
must
considered
in
preoperative
examination.
Language: Английский
Elevated CRP and IL6 Levels Predict Severe Cardiovascular Outcomes in COVID-19 Patients
Academia Open,
Journal Year:
2024,
Volume and Issue:
9(2)
Published: May 17, 2024
This
study
explores
the
association
between
C-reactive
protein
(CRP)
and
interleukin
6
(IL-6)
levels
cardiovascular
complications
in
COVID-19
patients.
Utilizing
an
ELISA
kit
for
IL-6
standard
tests
CRP,
we
analyzed
192
samples,
finding
higher
infection
rates
among
50-69
age
group,
with
significant
prevalence
of
morbid
obesity.
Results
showed
a
strong
correlation
elevated
CRP
severity
complications,
particularly
critical
cases.
These
findings
suggest
that
monitoring
these
biomarkers
could
be
crucial
early
intervention
managing
risks
patients,
potentially
improving
patient
outcomes
clinical
settings.
Highlights:
Biomarker
Correlation:
Elevated
are
linked
to
severe
Risk
Management:
Monitoring
helps
risks.
Demographic
Insights:
The
highest
complication
group
Keywords:
COVID-19,
Cardiovascular
Complications,
IL-6,
Language: Английский
Long-term mortality in different COVID-19 variants: 18-month follow-up
Russian Journal of Cardiology,
Journal Year:
2023,
Volume and Issue:
28(12), P. 5672 - 5672
Published: Dec. 20, 2023
The
viral
infection
and
pandemic
of
coronavirus
2019
(COVID-19)
was
characterized
not
only
by
high
morbidity
in-hospital
mortality,
but
also
an
increase
in
the
mortality
patients
after
hospital
discharge.
At
same
time,
differences
were
noted
hospitalization
rate,
number
complications
patients,
rate
between
different
waves
from
2020
to
2023.
Aim
.
To
compare
18-month
post-hospital
three
COVID-19
variants
(Alpha,
Delta
Omicron).
Material
methods
In
this
prospective,
single-center,
non-randomized
continuous
study,
2400
medical
records
with
Alpha
variant
(2020),
1826
(2021)
997
Omicron
(2022)
analyzed.
end
point
all-cause
during
follow-up
period.
Results
There
following
clinical
demographic
characteristics
context
strains:
more
women
hospitalized
waves;
wave,
older.
Also,
comorbid
common
than
(in
chronic
obstructive
pulmonary
disease,
hypertension
heart
failure),
kidney
disease
variants.
groups
differed
significantly
maximum
being
minimum
Omicron,
observed
first
90
days
Between
12
18
months,
survival
estimates
decreased
most
for
which
is
determined
risk
long-term
cardiovascular
consequences.
Conclusion
Clinical
variants,
as
well
a
significant
difference
waves,
emphasize
importance
personalized
approach
treatment
monitoring.
Language: Английский