Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 24, 2025
Flavonoids
are
a
class
of
important
polyphenolic
compounds,
renowned
for
their
antioxidant
properties.
However,
recent
studies
have
uncovered
an
additional
function
these
natural
flavonoids:
ability
to
inhibit
ferroptosis.
Ferroptosis
is
key
mechanism
driving
cell
death
in
central
nervous
system
(CNS)
diseases,
including
both
acute
injuries
and
chronic
neurodegenerative
disorders,
characterized
by
iron
overload-induced
lipid
peroxidation
dysfunction
the
defense
system.
This
review
discusses
therapeutic
potential
flavonoids
from
herbs
nutraceuticals
as
ferroptosis
inhibitors
CNS
focusing
on
molecular
mechanisms,
summarizing
findings
preclinical
animal
models,
providing
insights
clinical
translation.
We
specifically
highlight
such
Baicalin,
Baicalein,
Chrysin,
Vitexin,
Galangin,
Quercetin,
Isoquercetin,
Eriodictyol,
Proanthocyanidin,
(−)-epigallocatechin-3-gallate,
Dihydromyricetin,
Soybean
Isoflavones,
Calycosin,
Icariside
II,
Safflower
Yellow,
which
shown
promising
results
models
injuries,
ischemic
stroke,
cerebral
ischemia-reperfusion
injury,
intracerebral
hemorrhage,
subarachnoid
traumatic
brain
spinal
cord
injury.
Among
these,
Baicalin
its
precursor
Baicalein
stand
out
due
extensive
research
favorable
outcomes
injury
models.
Mechanistically,
not
only
regulate
Nrf2/ARE
pathway
activate
GPX4/GSH-related
pathways
but
also
modulate
metabolism
proteins,
thereby
alleviating
overload
inhibiting
While
show
promise
especially
settings,
further
needed
evaluate
efficacy,
safety,
pharmacokinetics,
blood-brain
barrier
penetration
application.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 11, 2025
The
present
study
was
to
investigate
potential
biomarkers
and
therapeutic
targets
for
epilepsy
by
conducting
a
transcriptomic
proteomic
analysis
of
human
brain
tissue
from
patients
with
epileptic
lesions.
Brain
collected
the
lesions
after
surgical
resection
removed
non-epileptic
patients.
Using
RNA
sequencing
iTRAQ-based
analysis,
identified
1,604
DEGs,
584
upregulated
1,020
downregulated.
694
DEPs,
331
363
combined
showed
that
DEGs
DEPs
were
mainly
enriched
in
biological
processes
such
as
D-aspartate
transport,
transmembrane
cell
junctions,
vesicle
metabolic
processes.
Tubulin
polymerization
promoting
protein
family
member-3
(TPPP3),
proprotein
convertase
subtilisin/kexin
type-1
(PCSK1),
dihydropyrimidinase-like
3
(DPYSL3)
significantly
altered
patients,
their
expression
trends
confirmed
RT-qPCR,
WB,
IHC
staining
results.
By
integrating
analyses,
we
genes
proteins
expressed
differently
associated
Three
key
(TPPP3,
PCSK1,
DPYSL3)
identified,
indicating
significance
pathological
mechanisms
epilepsy.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
A
novel
nanozyme
based
on
Ru
3+
-chelated
nanoscale
metal
organic
frameworks
(Ru
-NMOFs)
displayed
peroxidase-like
activity,
and
employed
in
inhibiting
disaggregating
β-amyloid
aggregates
both
vitro
vivo
.
Food and Agricultural Immunology,
Journal Year:
2024,
Volume and Issue:
35(1)
Published: Dec. 3, 2024
Neurodegenerative
diseases
(NDDs)
affect
millions
of
lives
worldwide.
They
constitute
a
group
neurological
disorders
with
shared
common
features,
including
impaired
cognition,
behavior,
memory,
and
motor
functions.
These
conditions
arise
due
to
the
gradual
degeneration
neurons
within
nervous
system.
Even
though,
each
pathology
presents
diverse
etiologies
develops
in
different
brain
sites,
they
may
share
cellular
molecular
mechanisms,
such
as
inflammation,
protein
aggregation,
DNA
RNA
defects.
Heavy
metal
contamination
is
global
public
health
concern,
given
that
anthropogenic
activities
like
paint
manufacturing,
mining,
oil
refining
contribute
substantially
heavy
pollution.
Consequently,
studies
have
investigated
its
potential
etiological
factors
neurodegenerative
diseases.
This
review
examines
impact
dietary
exposure
metals,
specifically
mercury,
cadmium,
lead,
chromium,
arsenic,
zinc,
on
development
progression
Evidence
from
range
indicates
these
metals
play
significant
role
advancing
by
disrupting
essential
functions,
induction
oxidative
stress
impairments
mitochondrial
function.
findings
underscore
need
for
further
research
elucidate
toxicological
mechanisms
develop
preventive
strategies,
chelation
therapies
environmental
remediation.
Addressing
risks
especially
critical
protect
neurocognitive
health,
particularly
aging
populations.
