
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100235 - 100235
Published: Oct. 1, 2024
Language: Английский
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100235 - 100235
Published: Oct. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 24, 2025
Flavonoids are a class of important polyphenolic compounds, renowned for their antioxidant properties. However, recent studies have uncovered an additional function these natural flavonoids: ability to inhibit ferroptosis. Ferroptosis is key mechanism driving cell death in central nervous system (CNS) diseases, including both acute injuries and chronic neurodegenerative disorders, characterized by iron overload-induced lipid peroxidation dysfunction the defense system. This review discusses therapeutic potential flavonoids from herbs nutraceuticals as ferroptosis inhibitors CNS focusing on molecular mechanisms, summarizing findings preclinical animal models, providing insights clinical translation. We specifically highlight such Baicalin, Baicalein, Chrysin, Vitexin, Galangin, Quercetin, Isoquercetin, Eriodictyol, Proanthocyanidin, (−)-epigallocatechin-3-gallate, Dihydromyricetin, Soybean Isoflavones, Calycosin, Icariside II, Safflower Yellow, which shown promising results models injuries, ischemic stroke, cerebral ischemia-reperfusion injury, intracerebral hemorrhage, subarachnoid traumatic brain spinal cord injury. Among these, Baicalin its precursor Baicalein stand out due extensive research favorable outcomes injury models. Mechanistically, not only regulate Nrf2/ARE pathway activate GPX4/GSH-related pathways but also modulate metabolism proteins, thereby alleviating overload inhibiting While show promise especially settings, further needed evaluate efficacy, safety, pharmacokinetics, blood-brain barrier penetration application.
Language: Английский
Citations
0Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: May 11, 2025
The present study was to investigate potential biomarkers and therapeutic targets for epilepsy by conducting a transcriptomic proteomic analysis of human brain tissue from patients with epileptic lesions. Brain collected the lesions after surgical resection removed non-epileptic patients. Using RNA sequencing iTRAQ-based analysis, identified 1,604 DEGs, 584 upregulated 1,020 downregulated. 694 DEPs, 331 363 combined showed that DEGs DEPs were mainly enriched in biological processes such as D-aspartate transport, transmembrane cell junctions, vesicle metabolic processes. Tubulin polymerization promoting protein family member-3 (TPPP3), proprotein convertase subtilisin/kexin type-1 (PCSK1), dihydropyrimidinase-like 3 (DPYSL3) significantly altered patients, their expression trends confirmed RT-qPCR, WB, IHC staining results. By integrating analyses, we genes proteins expressed differently associated Three key (TPPP3, PCSK1, DPYSL3) identified, indicating significance pathological mechanisms epilepsy.
Language: Английский
Citations
0Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A novel nanozyme based on Ru 3+ -chelated nanoscale metal organic frameworks (Ru -NMOFs) displayed peroxidase-like activity, and employed in inhibiting disaggregating β-amyloid aggregates both vitro vivo .
Language: Английский
Citations
1Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)
Published: Dec. 3, 2024
Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual degeneration neurons within nervous system. Even though, each pathology presents diverse etiologies develops in different brain sites, they may share cellular molecular mechanisms, such as inflammation, protein aggregation, DNA RNA defects. Heavy metal contamination is global public health concern, given that anthropogenic activities like paint manufacturing, mining, oil refining contribute substantially heavy pollution. Consequently, studies have investigated its potential etiological factors neurodegenerative diseases. This review examines impact dietary exposure metals, specifically mercury, cadmium, lead, chromium, arsenic, zinc, on development progression Evidence from range indicates these metals play significant role advancing by disrupting essential functions, induction oxidative stress impairments mitochondrial function. findings underscore need for further research elucidate toxicological mechanisms develop preventive strategies, chelation therapies environmental remediation. Addressing risks especially critical protect neurocognitive health, particularly aging populations.
Language: Английский
Citations
1Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
1European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100235 - 100235
Published: Oct. 1, 2024
Language: Английский
Citations
0