Targeting Alzheimer's Disease with Novel Dual-Function 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives DOI Creative Commons

Aikaterini Katsogiannou,

Danai Karta,

Antonio Di Stefano

et al.

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100235 - 100235

Published: Oct. 1, 2024

Language: Английский

Natural flavonoids from herbs and nutraceuticals as ferroptosis inhibitors in central nervous system diseases: current preclinical evidence and future perspectives DOI Creative Commons

Qiuhe Li,

Xiaohang Yang, Tiegang Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Flavonoids are a class of important polyphenolic compounds, renowned for their antioxidant properties. However, recent studies have uncovered an additional function these natural flavonoids: ability to inhibit ferroptosis. Ferroptosis is key mechanism driving cell death in central nervous system (CNS) diseases, including both acute injuries and chronic neurodegenerative disorders, characterized by iron overload-induced lipid peroxidation dysfunction the defense system. This review discusses therapeutic potential flavonoids from herbs nutraceuticals as ferroptosis inhibitors CNS focusing on molecular mechanisms, summarizing findings preclinical animal models, providing insights clinical translation. We specifically highlight such Baicalin, Baicalein, Chrysin, Vitexin, Galangin, Quercetin, Isoquercetin, Eriodictyol, Proanthocyanidin, (−)-epigallocatechin-3-gallate, Dihydromyricetin, Soybean Isoflavones, Calycosin, Icariside II, Safflower Yellow, which shown promising results models injuries, ischemic stroke, cerebral ischemia-reperfusion injury, intracerebral hemorrhage, subarachnoid traumatic brain spinal cord injury. Among these, Baicalin its precursor Baicalein stand out due extensive research favorable outcomes injury models. Mechanistically, not only regulate Nrf2/ARE pathway activate GPX4/GSH-related pathways but also modulate metabolism proteins, thereby alleviating overload inhibiting While show promise especially settings, further needed evaluate efficacy, safety, pharmacokinetics, blood-brain barrier penetration application.

Language: Английский

Citations

0

A transcriptomic and proteomic analysis and comparison of human brain tissue from patients with and without epilepsy DOI Creative Commons

Taiyang Zhu,

Yan Zhou, Lei Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 11, 2025

The present study was to investigate potential biomarkers and therapeutic targets for epilepsy by conducting a transcriptomic proteomic analysis of human brain tissue from patients with epileptic lesions. Brain collected the lesions after surgical resection removed non-epileptic patients. Using RNA sequencing iTRAQ-based analysis, identified 1,604 DEGs, 584 upregulated 1,020 downregulated. 694 DEPs, 331 363 combined showed that DEGs DEPs were mainly enriched in biological processes such as D-aspartate transport, transmembrane cell junctions, vesicle metabolic processes. Tubulin polymerization promoting protein family member-3 (TPPP3), proprotein convertase subtilisin/kexin type-1 (PCSK1), dihydropyrimidinase-like 3 (DPYSL3) significantly altered patients, their expression trends confirmed RT-qPCR, WB, IHC staining results. By integrating analyses, we genes proteins expressed differently associated Three key (TPPP3, PCSK1, DPYSL3) identified, indicating significance pathological mechanisms epilepsy.

Language: Английский

Citations

0

A Ru3+-Functionalized-NMOF Nanozyme as an Inhibitor and Disaggregater for β-Amyloid Aggregates DOI

Luo Wan-chun,

Lina Bao, Yufan Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A novel nanozyme based on Ru 3+ -chelated nanoscale metal organic frameworks (Ru -NMOFs) displayed peroxidase-like activity, and employed in inhibiting disaggregating β-amyloid aggregates both vitro vivo .

Language: Английский

Citations

1

Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk DOI Creative Commons
Patricia Guevara-Ramí­rez, Rafael Tamayo‐Trujillo, Santiago Cadena-Ullauri

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 3, 2024

Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual degeneration neurons within nervous system. Even though, each pathology presents diverse etiologies develops in different brain sites, they may share cellular molecular mechanisms, such as inflammation, protein aggregation, DNA RNA defects. Heavy metal contamination is global public health concern, given that anthropogenic activities like paint manufacturing, mining, oil refining contribute substantially heavy pollution. Consequently, studies have investigated its potential etiological factors neurodegenerative diseases. This review examines impact dietary exposure metals, specifically mercury, cadmium, lead, chromium, arsenic, zinc, on development progression Evidence from range indicates these metals play significant role advancing by disrupting essential functions, induction oxidative stress impairments mitochondrial function. findings underscore need for further research elucidate toxicological mechanisms develop preventive strategies, chelation therapies environmental remediation. Addressing risks especially critical protect neurocognitive health, particularly aging populations.

Language: Английский

Citations

1

Plant-derived compounds and neurodegenerative diseases: Different mechanisms of action with therapeutic potential DOI
Carolina Echeverry, Mariana Pazos,

Maximiliano Torres-Pérez

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1

Targeting Alzheimer's Disease with Novel Dual-Function 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives DOI Creative Commons

Aikaterini Katsogiannou,

Danai Karta,

Antonio Di Stefano

et al.

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100235 - 100235

Published: Oct. 1, 2024

Language: Английский

Citations

0