A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 796 - 796

Published: Jan. 15, 2025

Vitamin D, also called the “sunshine” vitamin, has gained great attention recently due to observed high percentage of worldwide population being deficient in this essential bioactive vitamin. Primarily, vitamin D was known for its important role bone health. Nevertheless, recent research shown importance brain, heart, muscles, immune system, and skin health, distinct bio-functionality almost every tissue human body. Therefore, deficiency been highly correlated with multiple diseases, including dermatologically associated ones. Moreover, different methodologies are applied synthesize while main sources plasma levels factors that can cause adverse modifications multiple. Further upon exhibited notable against such as psoriasis, atopic dermatitis, vitiligo, acne, rosacea. In article, a critical review most relevant significant information regarding relationship between health is thoroughly conducted, emphasis given potential uses benefits several cosmetic applications. Current status, limitations, future perspectives potent extensively discussed.

Language: Английский

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Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Cosmetics, Journal Year: 2024, Volume and Issue: 11(2), P. 37 - 37

Published: March 1, 2024

Vitamin D is a natural photoproduct that has many beneficial effects on different organs, including skin. Active forms of vitamin and its derivatives exert biological skin cells, thus maintaining homeostasis. In keratinocytes, they inhibit proliferation stimulate differentiation, have anti-inflammatory properties, act as antioxidants, DNA damage repair after ultraviolet (UV) exposure. melanocytes, also cell proliferation, apoptosis antioxidants. fibroblasts, affect fibrotic processes collagen production, promote wound healing regeneration. On the other hand, cells ability to activate directly. These activities, along with projected topical application derivatives, are promising for care photo protection can be used in prevention or possible reversal aging.

Language: Английский

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Innovative Approaches for Maintaining and Enhancing Skin Health and Managing Skin Diseases through Microbiome-Targeted Strategies

Antibiotics, Journal Year: 2023, Volume and Issue: 12(12), P. 1698 - 1698

Published: Dec. 4, 2023

The skin microbiome is crucial in maintaining health, and its disruption associated with various diseases. Prebiotics are non-digestible fibers compounds found certain foods that promote the activity growth of beneficial bacteria gut or skin. On other hand, live microorganisms, known as probiotics, benefit sustaining healthy conditions when consumed reasonable quantities. They differ from postbiotics, which by-product release same effects their parent bacteria. human vital it comes to health preventing a variety dermatological conditions. This review explores novel strategies use microbiome-targeted treatments maintain enhance overall while managing disorders. It important understand dynamic relationship between these microorganisms diverse microbial communities present on create effective for using probiotics understanding can help optimize formulations treatment regimens improved outcomes skincare, particularly developing solutions problems.

Language: Английский

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Vitamin D: Beyond Traditional Roles—Insights into Its Biochemical Pathways and Physiological Impacts

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 803 - 803

Published: Feb. 26, 2025

Background: It is true that vitamin D did not earn its title as the "sunshine vitamin" for nothing. In recent years, however, there has been a shift in perception surrounding to type of hormone boasts countless bioactivities and health advantages. Historically, known take care skeletal integrity calcium-phosphorus balance body, but new scientific research displays much larger spectrum actions handled by this vitamin. Materials Methods: A systematic literature search was performed using following electronic databases: PubMed, Scopus, Web Science, Embase, Cochrane Library. Results: Many emerging ideas, especially concerning alternative hormonal pathways analogs, are uniformly challenging classic "one hormone-one receptor" hypothesis. To add more context this, receptor (VDR) previously assumed be only means through which biologically active steroid 1,25-dihydroxyvitamin D3 could impact body. Two other molecules apart from form 1,25(OH)2D3 have gained interest these reinvigorated on metabolism. These metabolites can interact with several nuclear receptors (like related orphan alpha-RORα, gamma-RORγ, aryl hydrocarbon receptor-AhR) trigger various biological responses. Conclusions: This paper thus makes case placing at forefront holistic dermatological investigating potential synergies between canonical noncanonical pathways. now plentiful opportunities manipulating understanding full actions, far beyond those minerals.

Language: Английский

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Molecular insights of vitamin D receptor SNPs and vitamin D analogs: a novel therapeutic avenue for vitiligo

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

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Taiwanese Dermatological Association consensus recommendations for the diagnosis, assessment, and management of vitiligo

Dermatologica Sinica, Journal Year: 2025, Volume and Issue: 43(1), P. 14 - 25

Published: Jan. 1, 2025

Language: Английский

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Correlation between anthropometric and biological parameters of the offspring and parental plasma 25-hydroxyvitamin D levels: a cross-sectional study conducted at Oran, Algeria.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Background Vitamin D is critical in overall health, particularly during pregnancy, as it supports a healthy pregnancy and promotes proper fetal development. This study examined the link between parental 25-hydroxyvitamin (25(OH)D) deficiency their offspring's anthropometric biological parameters. Methods A cross-sectional was conducted involving 50 Algerian families, which included pregnant women third trimester, fathers, newborns. Blood samples were collected from both parents umbilical cord of Serum 25(OH)D concentrations measured, demographic health-related information gathered participants. The parameters newborns recorded at birth. Results In our study, 16% insufficient 25(OH)D, 54% deficient, remaining 30% exhibited severe deficiency, with mean levels 24.53 ng/ml, 14.23 7.69 respectively. Among males, 40% insufficient, 42% 18% had 25 15.78 8.53 Furthermore, 24% 52% 23.53 13.46 7.53 Maternal positively correlated (height, femur length, weight, Apgar scores 1 5 minutes after birth). Conversely, paternal showed no correlation these Conclusion significantly impacts represents significant risk to development, whereas has impact on measured

Language: Английский

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Impact of vitamin D on ultraviolet-induced photoaging and skin diseases

Exploration of Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 363 - 383

Published: May 20, 2024

Excessive exposure to ultraviolet (UV) radiation causes premature aging of the skin, known as photoaging. UV induces DNA damage, oxidative stress, inflammatory reactions, and degradation extracellular matrix (ECM) proteins, contributing aged skin phenotype. The synthesizes vitamin D upon UVB exposure, which plays a pivotal role in proper function multiple body systems. Vitamin protects from photo-damage by repairing cyclobutane pyrimidine dimers, reversing reducing chronic inflammation. Moreover, various epidemiological studies have identified deficiency marker for common dermatological disorders. Improvement clinical outcomes with supplementation further suggests its protective against pathologies. This review comprehensively covers involvement combating UV-induced photoaging disorders, highlighting significance maintaining adequacy healthy skin.

Language: Английский

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Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(21), P. 19323 - 19341

Published: Nov. 1, 2024

Vitiligo is the most common cause of depigmentation worldwide, with immunosuppressive treatments often being inefficient and prone to recurrence, making it essential identify new therapeutic targets. Periplakin (PPL) has been identified confirmed as a key factor in vitiligo-related depigmentation. Based on this, series selective PPL agonists, specifically benzenesulfonamides, have developed. Among these, compound I-3 exhibits superior efficacy compared ruxolitinib, only FDA-approved treatment for vitiligo. shown increase cAMP levels by regulating PPL, which enhances MITF expression, transcription melanin biosynthesis. Additionally, promotes production tryptophan metabolism. In summary, promising drug target, strong potential future vitiligo due its high selectivity favorable druggability.

Language: Английский

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Skin Disorders and Osteoporosis: Unraveling the Interplay Between Vitamin D, Microbiota, and Epigenetics Within the Skin–Bone Axis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 179 - 179

Published: Dec. 28, 2024

Growing scientific evidence suggests a strong interconnection between inflammatory skin diseases and osteoporosis (OP), systemic condition characterized by decreased bone density structural fragility. These conditions seem to share common pathophysiological mechanisms, including immune dysregulation, chronic inflammation, vitamin D deficiency, which play crucial role in both health. Additionally, the roles of gut microbiota (GM) epigenetic regulation via microRNAs (miRNAs) emerge as key elements influencing progression conditions. This review aims examine skin–bone axis, exploring how factors such D, GM, miRNAs interact subtle interplay driving inflammation immune-metabolic alterations. Recent research that combined therapeutic approaches—including supplementation, targeted interventions, miRNA-based therapies—could be promising strategies for managing comorbid OP. perspective highlights need multidisciplinary approaches clinical management related skin-bone axis.

Language: Английский

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