A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep
Yu Cai,
No information about this author
Hui Xu,
No information about this author
Kaiping Deng
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 141271 - 141271
Published: Feb. 1, 2025
Language: Английский
Identifying Shared Molecular Landscape between Uterine Fibroids and Recurrent Implantation Failure: An Integrated Bioinformatics Study
Heliyon,
Journal Year:
2025,
Volume and Issue:
unknown, P. e43006 - e43006
Published: Feb. 1, 2025
Language: Английский
IGF2BP2 regulates the proliferation and migration of endometrial stromal cells through the PI3K/AKT/mTOR signaling pathway in Hu sheep
Journal of Animal Science,
Journal Year:
2024,
Volume and Issue:
102
Published: Jan. 1, 2024
Abstract
Insulin-like
growth
factor
2
mRNA
binding
protein
(IGF2BP2),
a
significant
member
of
the
conserved
RNA-binding
family,
plays
various
roles
in
numerous
physiological
and
pathological
processes.
However,
specific
function
IGF2BP2
regulating
endometrial
sheep
remains
largely
unknown.
In
this
study,
we
observed
upregulation
abundance
endometrium
during
luteal
phase
compared
to
follicular
Hu
sheep.
The
knockdown
resulted
accelerated
cell
proliferation
migration
stromal
cells
(ESCs).
Moreover,
RNA
sequencing
analysis
revealed
that
genes
with
significantly
altered
expression
were
predominantly
enriched
receptivity-related
signaling
pathways,
such
as
cytokine-cytokine
receptor
interaction,
NOD-like
receptor,
PI3K-AKT,
JAK-STAT
pathway.
Additionally,
increased
matrix
metalloprotein
9
(MMP9),
vascular
endothelial
factor,
prolactin
(PRL)
ESCs.
was
also
stimulate
PI3K/AKT/mTOR
pathway
by
upregulating
integrin
β4
(ITGB4)
expression.
Notably,
downregulation
ITGB4
attenuates
knockdown-induced
facilitation
ESCs
inhibiting
Collectively,
these
findings
highlight
important
role
function,
particularly
through
modulation
ESC
via
Language: Английский
Heat Stress Impairs Endometrial Function During Implantation by Regulating Autophagy in Hainan Black Goat
Xiaoping Li,
No information about this author
Yanyu Sun,
No information about this author
Min Yi
No information about this author
et al.
Animals,
Journal Year:
2024,
Volume and Issue:
14(22), P. 3213 - 3213
Published: Nov. 8, 2024
Heat
stress
(HS)
is
a
significant
factor
that
adversely
affects
the
health,
welfare,
and
productivity
of
domestic
animals,
particularly
impacting
embryo
implantation
rates.
However,
effects
HS
on
endometrial
function
during
peri-implantation
period
in
Hainan
black
goats
remain
unclear.
This
study
explores
influence
endometrium
these
goats.
We
collected
uterine
tissue
samples
from
both
control
heat-stressed
performed
vitro
experiments
using
2
×
factorial
design.
design
included
two
temperature
conditions
(37
°C
as
42
to
simulate
heat
stress)
pharmacological
treatments:
chloroquine
(CQ),
an
autophagy
inhibitor,
rapamycin
(RAPA),
activator.
Our
results
showed
initially
suppresses
activity,
which
subsequently
enhanced
with
prolonged
exposure.
The
pharmacologic
modulation
autophagy,
through
activation
or
inhibition,
resulted
corresponding
upregulation
downregulation
epithelial
cells'
(EECs)
receptivity
markers.
overexpression
ATG7
partially
reversed
HS-induced
Additionally,
TJP1,
tight-junction
marker,
was
degraded
under
genetic
but
accumulated
more
EECs
pre-treated
CQ.
These
findings
suggest
plays
protective
role
maintaining
offers
valuable
insights
into
proposes
potential
strategy
mitigate
adverse
goat
reproduction.
Language: Английский