Triglycerides and Acne: Assessing the Impact of Blood Lipid Levels on Acne Severity in Young Adults DOI
Erika Martining Wardani, Riezky Faisal Nugroho

Journal of Current Health Sciences, Journal Year: 2024, Volume and Issue: 4(2), P. 87 - 94

Published: Oct. 27, 2024

Acne vulgaris is a common chronic inflammatory skin condition that predominantly affects adolescents and young adults. This study aimed to examine the relationship between elevated blood triglyceride levels incidence severity of acne in A cross-sectional design was utilized, involving 85 patients aged 17-25 years from cosmetic clinic Surabaya, Indonesia. Triglyceride were measured classified into two categories: normal (less than 150 mg/dL) high (more mg/dL). The assessed using Global Grading System (GAGS). Statistical analysis chi-square test revealed significant association (p = 0.03). However, no correlation found 0.09). These findings suggest while may increase risk developing vulgaris, other factors such as hormonal, genetic, lifestyle elements play more prominent role determining severity. Clinically, reducing through dietary interventions or pharmacological therapies serve preventive measure for vulgaris. Further research required explore mechanisms underlying this potential lipid management treatment.

Language: Английский

Exploring Isotretinoin’s Unexpected Acceleration of wound Healing: A rat model study DOI
Mohammad Hasan Maleki, Behnoosh Miladpour, Seyed Amirhossein Mazhari

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114145 - 114145

Published: Jan. 31, 2025

Language: Английский

Citations

0
Systematic Review of Rare Major Adverse Cardiovascular Events Associated With the Treatment of Acne With Isotretinoin DOI Creative Commons
Timothy Cowan,

Mark E. Stark,

Simona Sarmiento

et al.

Australasian Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Acne vulgaris is a common inflammatory condition that often treated by dermatologists with isotretinoin. Isotretinoin has number of effects on pathways, clear efficacy in managing acne vulgaris. There are also well-documented side isotretinoin, including hyperlipidemia; however, the overall cardiovascular risk unclear. This systematic review revealed low evidence for major adverse events associated use isotretinoin patients. Despite this evidence, rare may be and should still considered when using

Language: Английский

Citations

0
Recommendations to Improve Outcomes in Acne and Acne Sequelae: A Focus on Trifarotene and Other Retinoids DOI Creative Commons
Naiem T. Issa, Andrew Alexis,

Hilary Baldwin

et al.

Dermatology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Acne vulgaris affects nearly 50 million people in the USA, ranking as eighth most prevalent disease globally. This chronic inflammatory skin condition often results sequelae, including atrophic acne scars, acne-induced macular erythema and hyperpigmentation, impacting patients' quality of life. commentary article reviews use topical retinoids, with a particular emphasis on trifarotene cream 0.005%, for managing both sequelae. Topical retinoids are considered central to improving treatment outcomes because their established efficacy, safety tolerability. Adapalene, tretinoin tazarotene have demonstrated efficacy reducing sequelae several studies. Trifarotene has been extensively studied Phase 3 trials, demonstrating notable success treating mild-to-moderate acne. Recently, two large-scale, randomized, blinded, 4 clinical trials investigated 0.005% patients scarring hyperpigmentation across all Fitzpatrick phototypes. The START study found that there was greater reduction total scar count group compared vehicle at Week 24 (55.2% vs 29.9%) statistical significance early 2 (P = 0.001). Based this evidence, we recommend should be introduced first-line therapy Retinoids implemented into routine possible, especially darker phototypes or risk scarring. Furthermore, incorporated within comprehensive skincare regimen includes adequate photoprotection when Finally, management include maintenance retinoids. supports American Academy Dermatology's call guidance emphasizes need continued research optimize patient care.

Language: Английский

Citations

0
Plant-Based Foods for Chronic Skin Diseases: A Focus on the Mediterranean Diet DOI Creative Commons
Giuseppe Annunziata, Ludovica Verde, Alexander Zink

et al.

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 6, 2025

In this narrative review, we provide an overview of how adherence to a Mediterranean dietary pattern can complement traditional treatment strategies for psoriasis, acne, and hidradenitis suppurativa. We emphasize the importance integrated approach, with interventions as key component holistic patient care. Psoriasis, suppurativa are immune-mediated chronic diseases marked by systemic inflammation, genetic environmental factors influencing their onset. The diet, rich in plant-based foods antioxidant anti-inflammatory properties-such whole-grain cereals, extra-virgin olive oil, vegetables, legumes, fruits, nuts-has been shown reduce clinical severity these conditions. It also supports weight control positively impacts metabolic cardiovascular risk factors, which closely linked diseases. Dietary education, particularly about plays crucial role management skin serves important non-pharmacological option that influence prognosis. This review offers specific nutrition recommendations prescribing diet patients inflammatory

Language: Английский

Citations

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Multi-target mechanisms and potential applications of quercetin in the treatment of acne vulgaris DOI Creative Commons
Bo Yang, Yiming Li

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 7, 2025

Acne vulgaris, a prevalent inflammatory dermatosis, afflicts approximately 90% of adolescents globally. Despite the efficacy conventional therapies, including antibiotics and retinoids, their use is frequently limited by adverse effects emergence drug resistance. Quercetin, naturally occurring flavonoid, has garnered significant attention owing to its diverse biological activities, encompassing anti-inflammatory, antioxidant, antimicrobial, immunomodulatory properties. This review comprehensively explores multi-target mechanisms quercetin in treatment acne, focusing on ability modulate cytokine production, oxidative stress pathways, sebaceous gland activity, microbial populations. Additionally, promotes skin barrier repair reduces post-inflammatory hyperpigmentation scarring through antioxidant anti-fibrotic effects. promising vitro preclinical findings, challenges such as quercetin's low bioavailability lack robust clinical evidence necessitate further research. Advanced delivery systems, nanoparticles combination may optimize therapeutic potential. provides insights into molecular applications quercetin, highlighting potential safe effective alternative for acne management.

Language: Английский

Citations

0
Isotretinoin-Loaded Topical Lipid Liquid Crystal for the Treatment of Acne: In-Vitro and In-Vivo Evaluations DOI Creative Commons

Armita Sedighidarijani,

Shiva Golmohammadzadeh, Hossein Kamali

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: April 29, 2025

Abstract Effective acne treatment is critical due to its profound impact on physical and psychological well-being. It was shown that severe systemic side effects, including teratogenicity, ovarian reserve reduction, depression, dry skin, hypertriglyceridemia, intracranial hypertension limited oral isotretinoin usage. Therefore, this study addresses these challenges by developing isotretinoin-loaded lipid liquid crystal (LLC-IT) nanoparticles for topical application, aiming enhance localized delivery while minimizing exposure. LLC-IT were prepared using a top-down method evaluated their physicochemical properties, photostability, cytotoxicity, antimicrobial activity, in-vitro drug release, in-vivo therapeutic efficacy. A testosterone-induced mouse model used compare with untreated commercial gel-treated groups. exhibited uniform particle size (69.57 ± 0.51 nm), low polydispersity index (0.264 0.01), stable zeta potential (- 19.3 0.2 mV). High encapsulation efficiency (95% 3) effective loading capacity (1.15% 0.13) achieved. Drug release diffusion-controlled minimal UV-induced degradation. Stability assessments over 12 months confirmed consistent properties across varying storage temperatures. displayed significant antibacterial activity reduced skin irritation in Draize tests compared gels. In-vivo , inflammation significantly more than or groups, indicating enhanced efficacy of formulation. The formulation shows superior stability effects conventional treatments, offering patient-friendly solution, as well promising alternative industrial production management. Graphical

Language: Английский

Citations

0
Spatiotemporal Expression of IRS-1 During Brain Development and its Role in Neural Stem Cell Differentiation DOI

Junjiao Zhang,

Xiao Li, Fan Zhang

et al.

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: May 2, 2025

Language: Английский

Citations

0
INTERVENÇÕES TERAPÊUTICAS PARA O CONTROLE E TRATAMENTO DE ACNE: ESTUDO DE CASO DOI
Carla Barreto Silva de Cerqueira,

Thaís Botelho Lima,

Isadora de Carvalho Hegouet

et al.

Revista Contemporânea, Journal Year: 2025, Volume and Issue: 5(5), P. e8072 - e8072

Published: May 9, 2025

No mundo atual, a preocupação com aparência física é crescente e impulsionada pelas mídias sociais. Algumas disfunções inestéticas vão de encontro esse objetivo, exemplo da acne. Esta, uma disfunção cutânea que afeta em média 85% população, impacta negativamente qualidade vida dos pacientes influenciada por hábitos alimentares condições hormonais emocionais, como o estresse. O presente estudo caso seguiu as diretrizes CARE descreve abordagem terapêutica bioativos recursos eletroterapêuticos paciente 29 anos acne inflamatória há quase 10 anos, não obteve resultados satisfatórios tratamentos anteriores. Após realização do exame clínico detalhado, foi estabelecido um plano tratamento consistiu na utilização terapia alta frequência, fotobiomodulação laser bioativos, seguida máscara calmante, fotodocumentação reavaliação após 48 horas. As intervenções utilizadas demonstraram efeito promissor no das lesões acnéicas paciente.

Citations

0
Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence DOI Creative Commons
Marco Rocha, M. Saint Aroman, V. Mengeaud

et al.

International Journal of Women s Health, Journal Year: 2024, Volume and Issue: Volume 16, P. 663 - 678

Published: April 1, 2024

Abstract: Previously considered a skin disease exclusively affecting adolescents, characterized by inflammatory and non-inflammatory lesions, acne vulgaris is now increasingly observed in adult life, including post-menopause. Today, female (AFA) common chronic of the pilosebaceous unit, with polymorphic lesions presenting as open or closed comedones, papules, pustules, even nodules cysts, often presence sequelae. AFA may persist from adolescence manifest de novo adulthood. Its etiology multifactorial, involving genetic, hormonal, dietary, environmental factors, yet still incompletely understood. Increased sebum production, keratinocyte hyper-proliferation, inflammation, reduced diversity Cutibacterium acnes strains are underlying mechanisms. During menopausal transition, relative increase androgen levels occurs, just estrogens begin to decline, which can itself acne. Whereas most exhibit few normo-androgenic serum levels, baseline investigations testing panel enable associated comorbidities be eliminated, such polycystic ovarian syndrome, congenital adrenal hyperplasia, tumors. Another interesting feature AFA's impact on quality greater than being similar other diseases like asthma. The therapeutic approach depends its severity features. This review investigates intricate facets AFA, specific focus incidence rates, treatment modalities, curious menopause. Utilizing insights contemporary literature scientific discussions, this article seeks advance our understanding offering new perspectives shape clinical practices improve patient outcomes. Keywords: acne, epidemiology, treatment, dermocosmetics, menopause, hormonal dynamics

Language: Английский

Citations

2
Exploring Stress-Induced Mechanisms in Acne Pathogenesis DOI Creative Commons

Ifrah Siddiqui,

Ubaid Rais,

Mehak Tahir

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Abstract Background: Acne vulgaris affects millions worldwide, with psychological stress emerging as a significant contributor to its development. Stress influences acne via hormonal fluctuations, inflammation, immune modulation, altered skin barrier function, and lifestyle changes. Understanding these mechanisms is crucial for developing effective management strategies. This study aims elucidate the role of in pathogenesis inform more targeted interventions.Methods: A comprehensive search encompassing databases such PubMed, MEDLINE, Google Scholar, open access / subscription-based journals, was conducted retrieve relevant articles investigation key through which impacts development exacerbation. Articles were searched without any date restrictions. Utilizing criteria delineated methodology section, studies systematically reviewed relationship between adheres PRISMA guidelines (Preferred Reporting Items Systematic Reviews Meta-Analyses).Results: Our revealed multiple Hormonal including increases cortisol androgens, stimulate sebaceous gland activity, leading excess sebum production. Inflammation, triggered by stress-induced cytokine release, exacerbates lesions. also impairs alters responses, factors diet, sleep, skincare habits, all contribute severity. Additionally, neuropeptides, oxidative stress, insulin resistance, pH, vascular changes, changes microbiome play roles pathogenesis. These findings highlight varied nature stress-acne interactions underscore importance addressing both physiological strategies.Conclusion: reveals stress's impact on function impairment, behavioral factors, distress, alterations. Addressing underscores need holistic strategies integrating reduction techniques conventional treatments. interplay emphasizes approaches improve outcomes, recognizing bidirectional

Language: Английский

Citations

2