Triglycerides and Acne: Assessing the Impact of Blood Lipid Levels on Acne Severity in Young Adults DOI
Erika Martining Wardani, Riezky Faisal Nugroho

Journal of Current Health Sciences, Journal Year: 2024, Volume and Issue: 4(2), P. 87 - 94

Published: Oct. 27, 2024

Acne vulgaris is a common chronic inflammatory skin condition that predominantly affects adolescents and young adults. This study aimed to examine the relationship between elevated blood triglyceride levels incidence severity of acne in A cross-sectional design was utilized, involving 85 patients aged 17-25 years from cosmetic clinic Surabaya, Indonesia. Triglyceride were measured classified into two categories: normal (less than 150 mg/dL) high (more mg/dL). The assessed using Global Grading System (GAGS). Statistical analysis chi-square test revealed significant association (p = 0.03). However, no correlation found 0.09). These findings suggest while may increase risk developing vulgaris, other factors such as hormonal, genetic, lifestyle elements play more prominent role determining severity. Clinically, reducing through dietary interventions or pharmacological therapies serve preventive measure for vulgaris. Further research required explore mechanisms underlying this potential lipid management treatment.

Language: Английский

The effect of isotretinoin therapy on the circulatory system DOI Creative Commons

Paula Banderowicz,

Agnieszka Roszyk, Natalia Wierzbowska

et al.

Forum Dermatologicum, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 16, 2024

Isotretinoin is a drug belonging to the group of retinoids, which mainly used in dermatology. Through its mechanism action, it leads reduction sebum production, effectively inhibits formation acne. Unfortunately, this exhibits numerous side effects. This study aimed review literature terms clinical cases and articles on effects isotretinoin context cardiovascular system. It has been proven that can harm circulatory system, causing changes structure heart walls, thromboembolic episodes, coronary events lipid metabolism disorders. Further trials are needed better understand these

Language: Английский

Citations

1
Deficit of Omega-3 Fatty Acids in Acne Patients—A Cross-Sectional Pilot Study in a German Cohort DOI Creative Commons
Anne Guertler, Tobias Fiedler,

Diana Lill

et al.

Life, Journal Year: 2024, Volume and Issue: 14(4), P. 519 - 519

Published: April 17, 2024

Omega-3 fatty acids (ω-3 FAs) exert anti-inflammatory effects, including the downregulation of pro-inflammatory cytokines, eicosanoids, and insulin-like growth factor-1. Therefore, they may improve acne severity as an adjunct treatment. However, there is a paucity data regarding patients’ existing deficits. The aim this study was to determine ω-3 FA levels in patients correlation with self-reported dietary preferences clinical severity. A single-center, cross-sectional 100 conducted. Patients’ blood parameters, FAs levels, were assessed using HS-omega-3 Index® erythrocytes (Omegametrix® GmbH, Martinsried, Germany). Dietary standardized food frequency questionnaire. Clinical dermatologic evaluation performed Investigator Global Assessment (IGA) acne. values outside recommended range 8–11% 96 (mean 5.15%), independent or affected anatomic sites. severe deficit (HS-omega-3 < 4%) seen more commonly men than women (p = 0.021). regular consumption legumes significantly associated higher 0.003), oral supplementation 0.006) lack sunflower oil intake 0.008). This pilot demonstrated German cohort. Higher observed legume supplementation. Further prospective studies are needed investigate whether improves normal Index®.

Language: Английский

Citations

1
Cytarabine chemotherapy induces meibomian gland dysfunction DOI
Ren Liu,

Jianwen Xue,

Jiaxu Han

et al.

The Ocular Surface, Journal Year: 2024, Volume and Issue: 34, P. 444 - 458

Published: Oct. 1, 2024

Language: Английский

Citations

1
Role of Vitamin A on the Ocular Surface DOI
Huanhuan Ge, Guohu Di,

Peirong Song

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110179 - 110179

Published: Nov. 1, 2024

Language: Английский

Citations

1
Significance of host antimicrobial peptides in the pathogenesis and treatment of acne vulgaris DOI Creative Commons
Agata Lesiak, Paulina Paprocka, Urszula Wnorowska

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Acne vulgaris (AV) is a chronic inflammatory condition of the pilosebaceous units characterized by multiple immunologic, metabolic, hormonal, genetic, psycho-emotional dysfunctions, and skin microbiota dysbiosis. The latter manifested decreased population (phylotypes, i.e., genetically distinct bacterial subgroups that play different roles in health disease) diversity predominant commensal -

Language: Английский

Citations

1
Research progress on the role of macrophages in acne and regulation by natural plant products DOI Creative Commons
Dan Zhao, Yun Wang, Shuhui Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 26, 2024

Acne vulgaris is one of the most common skin diseases. The current understanding acne primarily revolves around inflammatory responses, sebum metabolism disorders, aberrant hormone and receptor expression, colonization by Cutibacterium acnes, abnormal keratinization follicular sebaceous glands. Although precise mechanism action remains incompletely understood, it plausible that macrophages exert an influence on these pathological features. Macrophages, as a constituent human innate immune system, typically manifest distinct phenotypes across various It has been observed polarization toward M1 phenotype plays pivotal role in pathogenesis acne. In recent years, extensive research revealed increasing number natural remedies exhibiting therapeutic efficacy through modulation macrophage polarization. This review investigates cutaneous macrophages, elucidates their potential significance acne, prevalent chronic disorder, explores mechanisms plant products targeting macrophages. Despite insights, poorly elucidated. Subsequent investigations this domain will further illuminate potentially offer guidance for identifying novel targets condition.

Language: Английский

Citations

0
TRADITIONAL AND ALTERNATIVE METHODS OF ACNE TREATMENT DOI Open Access
O. V. Bezeha, Ya.О. Yemchenko, К. V. Vasylyeva

et al.

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(2), P. 244 - 249

Published: May 20, 2024

Acne, characterized by chronic inflammation of the skin, has a multifactorial pathogenesis. Despite array available treatments, it remains one most prevalent dermatological conditions globally. While primarily affecting adolescents, noteworthy and escalating number cases occur in adults, particularly women. The complex pathogenesis acne encompasses follicular hyperkeratinization, colonization Cutibacterium acnes, sebum production, intricate inflammatory processes involving innate acquired immunity, neuroendocrine mechanisms, genetic non-genetic factors. Risk factors include adolescence, familial predisposition, oily skin. Although numerous treatments exist, ongoing efforts aim to mitigate side effects such as skin irritation, dryness, photosensitivity, while enhancing efficacy through refined formulations novel drugs with innovative mechanisms action. Emerging products target various aspects acne's pathogenesis, offering promising advancements treatment options. With concern over antibiotic resistance, current guidelines advocate for judicious use oral antibiotics emphasize exploring alternative treatments. Isotretinoin stands out highly efficacious therapy acne: operates reducing sebaceous gland size, decreasing secretion, regulating cell proliferation keratinization, also possessing anti-inflammatory immunomodulatory properties. Spironolactone plays an important role treatment; functioning synthetic aldosterone receptor antagonist anti-androgenic attributes. Androgens exert significant physiological on renewal, hair follicle growth, proliferation, embryogenesis. Topical therapies serve viable options both initial maintenance acne. They can be utilized monotherapy (excluding topical antibiotics) or combination other products.

Language: Английский

Citations

0
Acne vulgaris revisited: from pathogenesis to treatment strategies DOI Open Access

Ju Qiang,

Jiaqi Li

Chinese Journal of Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

摘要: 【摘要】 寻常痤疮是毛囊皮脂腺单位慢性炎症性疾病,其发病机制与雄激素诱导的脂质大量分泌、毛囊皮脂腺导管角化异常、毛囊微生物增殖及炎症和免疫反应密切相关,但具体的发病机制和病理生理过程仍未完全揭示。近年来随着研究不断深入,传统认知也不断更新并影响着临床治疗理念的转变。本文从激素水平、毛囊微生物、毛囊皮脂腺干细胞分化及重度痤疮发生机制等角度总结寻常痤疮发生机制中部分新观点、新理念及其在临床防治中的意义,为痤疮防治提供新的方向和思路。

Citations

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Acne and Rosacea DOI
Winston Liu,

Choon Fong Liew,

Hazel H. Oon

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 293 - 304

Published: Jan. 1, 2024

Language: Английский

Citations

0
Skin Microbiome and Acne: Microbial Imbalances and Impact – Interview with Three Key Opinion Leaders DOI Creative Commons

Brigitte Scott

EMJ Dermatology, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 94

Published: Nov. 7, 2024

Acne vulgaris, commonly known as acne, is a multifactorial, chronic inflammatory skin condition involving the pilosebaceous unit, and one of most common diseases globally. significantly impacts quality life wellbeing patients, can be associated with anxiety, depression, low self-esteem. This also substantial healthcare costs economic burden for society. The treatment acne complex challenging. For this article, EMJ conducted an interview in September 2024 key opinion leaders Marco Rocha from Federal University São Paulo, Brazilian Society Dermatology, Brazil; Thomas Dirschka CentroDerm Clinic, Wuppertal, Witten-Herdecke, Germany; Alison Layton Skin Research Centre, Hull York Medical School, York, Harrogate District NHS Foundation Trust, UK. leaders, who have wealth experience expertise clinical management were asked about current landscape potential role microbiome development disease. experts provided valuable insights into some many unmet needs management, particularly overuse antibiotics lack effective alternative therapies condition. discussed contribution microbial imbalances prebiotics probiotics restoring health. concept integrating microbiome-modulating strategies conventional treatment, whether there connection between psychological conditions such considered. A further topic covered was educating patients parents acne. Finally, outlined what future might look like.

Language: Английский

Citations

0