Luminescent Lanthanide Infinite Coordination Polymers for Ratiometric Sensing Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 396 - 396

Published: Jan. 18, 2025

Ratiometric lanthanide coordination polymers (Ln-CPs) are advanced materials that combine the unique optical properties of ions (e.g., Eu3+, Tb3+, Ce3+) with structural flexibility and tunability polymers. These widely used in biological chemical sensing, environmental monitoring, medical diagnostics due to their narrow-band emission, long fluorescence lifetimes, excellent resistance photobleaching. This review focuses on composition, sensing mechanisms, applications ratiometric Ln-CPs. The mechanism relies two distinct emission bands, which provides a self-calibrating, reliable, precise method for detection. relative intensity ratio between these bands varies concentration target analyte, enabling real-time monitoring minimizing interference. approach is particularly suitable detecting trace analytes use complex environments where factors like background noise, temperature fluctuations, light variations may affect results. Finally, we outline future research directions improving design synthesis Ln-CPs, such as incorporating long-lifetime reference luminescent molecules, exploring near-infrared systems, developing up-conversion or two-photon materials. Progress areas could significantly broaden scope Ln-CP applications, especially biosensing, other fields.

Language: Английский

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Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1158 - 1158

Published: Sept. 25, 2024

Hydrogen sulfide (H

Language: Английский

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Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3521 - 3521

Published: March 20, 2024

The phrase “Let food be thy medicine…” means that can a form of medicine and food; in other words, the diet we eat have significant impact on our health well-being. Today, this is gaining prominence as more scientific evidence suggests one’s help prevent treat disease. A rich fruits, vegetables, whole grains, lean protein reduce risk heart disease, cancer, diabetes, problems and, hand, processed foods, added sugars, saturated fats increase same diseases. Electrophilic compounds health, they are molecules covalently modify cysteine residues present thiol-rich Keap1 protein. These bind to activate NRF2, which promotes its translocation nucleus binding DNA ARE region, triggering antioxidant response protecting against oxidative stress. include polyphenols flavonoids nucleophilic but converted electrophilic quinones by metabolic enzymes such polyphenol oxidases (PPOs) sulfur foods Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) garlic. This review summarizes current knowledge subject.

Language: Английский

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Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 746 - 746

Published: June 24, 2024

Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development leukemia cells involves substantial disturbances within cellular machinery, offering hope search for effective selective treatments that could improve 5-year survival rate. Consequently, pathophysiological processes focus critical research. Enzymes such as cystathionine beta-synthase and sulfurtransferases like thiosulfate sulfurtransferase, 3-mercaptopyruvate gamma-lyase play vital role sulfur metabolism. These enzymes essential to maintaining homeostasis, providing robust antioxidant defenses, supporting cell division. Numerous studies have demonstrated cancerous can alter expression activity these enzymes, uncovering potential vulnerabilities or molecular targets cancer therapy. Recent laboratory research has indicated certain lines may exhibit changes patterns enzymes. Analysis scientific literature online datasets confirmed variations enzyme function specific leukemic compared normal leukocytes. This comprehensive review collects analyzes available information on lines, valuable insights identifying new pathways this field.

Language: Английский

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Hydrogen Sulfide Modulation of Matrix Metalloproteinases and CD147/EMMPRIN: Mechanistic Pathways and Impact on Atherosclerosis Progression

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1951 - 1951

Published: Aug. 26, 2024

Atherosclerosis is a chronic inflammatory condition marked by endothelial dysfunction, lipid accumulation, cell infiltration, and extracellular matrix (ECM) remodeling within arterial walls, leading to plaque formation potential cardiovascular events. Key players in ECM inflammation are metalloproteinases (MMPs) CD147/EMMPRIN, surface glycoprotein expressed on cells, vascular smooth muscle cells (VSMCs), immune that regulates MMP activity. Hydrogen sulfide (H₂S), gaseous signaling molecule, has emerged as significant modulator of these processes including oxidative stress mitigation, reduction, remodeling. This systematic review investigates the mechanistic pathways through which H₂S influences MMPs CD147/EMMPRIN assesses its impact atherosclerosis progression. A comprehensive literature search was conducted across PubMed, Scopus, Web Science databases, focusing studies examining modulation contexts. Findings indicate modulates expression activity transcriptional regulation post-translational modifications, S-sulfhydration. By mitigating stress, reduces activation, contributing stability also downregulates via pathways, diminishing responses cellular proliferation plaques. The dual regulatory role inhibiting downregulating CD147 suggests therapeutic agent stabilizing atherosclerotic plaques inflammation. Further research warranted elucidate precise molecular mechanisms explore H₂S-based therapies for clinical application atherosclerosis.

Language: Английский

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UCST Polymeric H₂S‐Donor Fabricated Nanomedicine Managing Atherosclerosis by Gas‐Photothermal Therapy Involving a “Turning Waste into Treasure” Strategy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Atherosclerosis (AS) stands as a primary cause of vascular diseases worldwide, with its occurrence and progression being attributed to the interplay multiple risk factors. Therefore, it is imperative develop comprehensive strategy aimed at effectively mitigating reversing AS. Herein, hydrogen sulfide (H 2 S) donor incorporated into thermal‐sensitive polymer possessing an upper critical solution temperature (UCST), which not only serves novel macromolecular H S but also forms targeted nanocarrier for delivering near infrared II photothermal agent, achieving gas‐photothermal therapy against AS notable advantages. For one aspect, multifunctional UCST nanomedicine could target atherosclerotic plaque perform photoacoustic imaging‐guided S‐photothermal reduce ratio en‐face aortic lesion areas from 17.2% 6.5% alleviate inflammatory microenvironment. another inevitable hepatic accumulation would activate 5'‐adenosine monophosphate (AMP)‐activated protein kinase/mammalian rapamycin signaling pathway, thereby enhancing lipid metabolism reducing plasma triglyceride levels. This transformation waste valuable asset further aids in inhibiting Consequently, here mediate effective attenuate

Language: Английский

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A Superoxide Anion Responsive and Self-Reporting Fluorescent H2s Donor for the Treatment of Diabetic Wound

Published: Jan. 1, 2025

Language: Английский

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Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 344 - 344

Published: Feb. 27, 2025

Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.

Language: Английский

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Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Kawasaki disease (KD) is a severe pediatric vasculitis leading to coronary artery complications. Hydrogen sulfide (H2S), recognized endogenous gasotransmitter with anti-inflammatory properties, offers potential as novel treatment for KD through its cardiovascular benefits. However, the specific effects and underlying mechanisms remain unclear. The objective of present study investigate therapeutic exogenous H2S in using network pharmacology experimental validation. By online database searches, total 405 pharmacological targets H2S, 826 KD-related targets, 107 were identified. Through PPI analysis Cytoscape screening, 9 hub genes filtered, namely TNF, IL6, JUN, AKT1, IL1B, TP53, NFKB1, MAPK1, RELA. KEGG pathway enrichment indicated that TLR4/MyD88/NF-κB signaling may play crucial role on KD. Additionally, vivo experiments confirmed sodium hydrosulfide (NaHS), an donor, markedly improved body weight, reduced inflammatory pathology arteries, downregulated levels cytokines TNF-α, IL-1β, IL-6. Furthermore, WB NaHS inhibited expression TLR4, MyD88, NF-κB, p-NF-κB. In brief, it first reveal attenuates response via pathway, highlighting approach These findings lay foundation further development H2S-based therapies management.

Language: Английский

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Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119608 - 119608

Published: March 1, 2025

Language: Английский

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