Exploring novel pharmacological trends: Natural compounds in dry eye disease management DOI Creative Commons
Tibor Rák, Adrienne Csutak

Acta Pharmaceutica, Journal Year: 2024, Volume and Issue: 74(3), P. 383 - 404

Published: Sept. 1, 2024

Abstract Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity quality of life influenced age, gender, environmental factors. The first line treatment consists dynamically developing artificial tears, gels, eyelid sprays, which can be supplemented with natural ingredients for enhanced efficacy. Other therapeutic steps include auto-logous serum anti-inflammatory immunosuppressive eyedrops, or oral tablets. Management also targets Meibomian gland dysfunction the surface micro-biome. This article explores various approaches, including compounds complementary strategies. Natural compounds, such as vitamins, herbal substances ( e.g ., trehalose), offer promising benefits enhancing stability protection. Apitherapeutic products manuka honey propolis exhibit antibacterial properties. Additionally, human tissue-derived solutions, tears amniotic membrane extracts, hold potential regeneration. strategies, polyherbal drops, liposomal microbiome-supporting solutions alternative avenues. Moreover, patient education, lifestyle modifications, interdisciplinary collaboration play crucial roles DED management, emphasizing importance holistic care approaches.

Language: Английский

Complementary Practices in Pharmacy and Their Relation to Glaucoma—Classification, Definitions, and Limitations DOI Creative Commons
Tibor Rák, Adrienne Csutak

Scientia Pharmaceutica, Journal Year: 2024, Volume and Issue: 92(1), P. 16 - 16

Published: March 14, 2024

Background: Traditional and evidence-based medicines, as seen depicted throughout human history, reportedly first begin with the application of medicinal plants, animal products, or inorganic minerals a basic framework towards effectively engineering prototypes generally aligned to pharmaceuticals medical nutrition. The growing global trend complementary treatments for glaucoma can be explained by intraocular pressure (IOP)-independent mechanisms disease its interpretation progressive neurodegenerative disorder. Unfortunately, categorical positions major fields applied popular therapies their relation are consistently neglected. Methods: In consideration bibliographic resources, most well-known online scientific databases were searched. Conclusion: rising popularity trends products coming onto market cannot escape attention pharmacists ophthalmologists, patients suffering from eye diseases also increasingly looking such products. Most them still lack knowledge appropriate evidence side effect profiles. Our proposed systematic charts demonstrate position each mainstream therapy sciences distinctively unique; we could not find any similar relevant illustration resource among published international literature.

Language: Английский

Citations

5
Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases DOI

Yufei Yao,

Qiannan Cao,

Huapan Fang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

Citations

0
Combined Herbal Eye Drops Exhibit Neuroprotective and Intraocular Pressure-Reducing Effects in a Glaucoma Rat Model DOI Creative Commons
Tibor Rák,

Evelin Patkó,

Edina Szabó

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 549 - 549

Published: May 1, 2025

(1) Background: Glaucoma is a multifactorial group of diseases characterized by progressive optic neuropathy. Intraocular pressure (IOP) the only successfully modifiable risk factor for all forms glaucoma. However, recent research has highlighted reduction oxidative stress and neuroinflammation as promising therapeutic targets. In this study, we evaluated antiglaucomatous effects combined herbal extract applied eye drops in rat model (2) Methods: Sprague Dawley rats were divided into four groups: healthy controls, glaucomatous animals treated with preservative-free artificial tears, groups receiving herbal-based 8 weeks. was induced through injection microbeads anterior chamber at week 1 3. Before first weeks 4 8, underwent optical coherence tomography (OCT) electroretinogram (ERG) recordings. Retinal analyses conducted to assess retinal ganglion cell (RGC) count, vessel density, markers neural pathways, stress, inflammation. (3) Results: The combination extracts showed beneficial on IOP elevation, significantly improved ERG responses. Neuroprotective assessed using OCT, immunohistochemistry, proteomics. Most parameters drop-treated not statistically different from those controls. (4) Conclusions: Topical administration plant-based compounds may serve an effective supportive therapy ocular hypertension neuroprotection.

Language: Английский

Citations

0
Exploring novel pharmacological trends: Natural compounds in dry eye disease management DOI Creative Commons
Tibor Rák, Adrienne Csutak

Acta Pharmaceutica, Journal Year: 2024, Volume and Issue: 74(3), P. 383 - 404

Published: Sept. 1, 2024

Abstract Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity quality of life influenced age, gender, environmental factors. The first line treatment consists dynamically developing artificial tears, gels, eyelid sprays, which can be supplemented with natural ingredients for enhanced efficacy. Other therapeutic steps include auto-logous serum anti-inflammatory immunosuppressive eyedrops, or oral tablets. Management also targets Meibomian gland dysfunction the surface micro-biome. This article explores various approaches, including compounds complementary strategies. Natural compounds, such as vitamins, herbal substances ( e.g ., trehalose), offer promising benefits enhancing stability protection. Apitherapeutic products manuka honey propolis exhibit antibacterial properties. Additionally, human tissue-derived solutions, tears amniotic membrane extracts, hold potential regeneration. strategies, polyherbal drops, liposomal microbiome-supporting solutions alternative avenues. Moreover, patient education, lifestyle modifications, interdisciplinary collaboration play crucial roles DED management, emphasizing importance holistic care approaches.

Language: Английский

Citations

1