Differential effect of cerium nanoparticles on the viability, redox-status and Ca2+-signaling system of cancer cells of various origins. DOI
Е. Г. Варламова, Sergey V. Gudkov, Egor A. Turovsky

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 764, P. 110261 - 110261

Published: Dec. 5, 2024

Language: Английский

Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis DOI Creative Commons

Xue Xiao,

Guoquan Huang, Xinqiao Yu

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 251 - 265

Published: Jan. 1, 2025

Selenium (Se), a critically essential trace element, plays crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, pathological condition caused by various factors, has become significant global health issue. Numerous studies have demonstrated substantial impact of Se on fibrotic diseases. This review delves into latest research advancements Se-related biological agents for alleviating fibrosis heart, liver, lungs, kidneys, detailing their mechanisms action pathways. Additionally, article summa-rizes some anti-fibrotic drugs currently clinical trials aforementioned organ fibroses.

Language: Английский

Citations

1
Endoplasmic reticulum stress in liver fibrosis: Mechanisms and therapeutic potential DOI
Tiantian Wang,

Guoqing Xia,

Xue Li

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167695 - 167695

Published: Jan. 1, 2025

Language: Английский

Citations

1
Liver cirrhosis: molecular mechanisms and therapeutic interventions DOI Creative Commons
Zihe Dong, Yeying Wang, Weilin Jin

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 17, 2024

Liver cirrhosis is the end-stage of chronic liver disease, characterized by inflammation, necrosis, advanced fibrosis, and regenerative nodule formation. Long-term inflammation can cause continuous damage to tissues hepatocytes, along with increased vascular tone portal hypertension. Among them, fibrosis necessary stage essential feature cirrhosis, effective antifibrosis strategies are commonly considered key treating cirrhosis. Although different therapeutic aimed at reversing or preventing have been developed, effects not be more satisfactory. In this review, we discussed abnormal changes in microenvironment that contribute progression highlighted importance recent strategies, including lifestyle improvement, small molecular agents, traditional Chinese medicine, stem cells, extracellular vesicles, gut remediation, regulate Meanwhile, for nanoparticles discussed, as their possible underlying broad application prospects ameliorating Finally, also reviewed major challenges opportunities nanomedicine‒biological environment interactions. We hope review will provide insights into pathogenesis mechanisms thus facilitating new methods, drug discovery, better treatment

Language: Английский

Citations

6
Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics DOI Creative Commons
Yujia Shu, Xuanfu Wu, Dongxu Zhang

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 81 - 81

Published: Jan. 16, 2025

Iron is a trace element that indispensable for the growth and development of animals. Excessive iron supplementation may lead to overload elevated reactive oxygen species (ROS) production in animals, causing cellular damage. Nevertheless, precise mechanism by which causes cell injury remains be fully elucidated. In this study, 16 male SD rats aged 6 7 weeks were randomly assigned either control group (CON) or an (IO). Rats received 150 mg/kg dextran injections every three days duration four weeks. The results indicated treatment with significantly increased scores steatosis (p < 0.05) inflammation NAS score. integrated transcriptomic proteomic analysis suggests HO-1 Lnc286.2 are potentially significant overload-induced liver rats. vitro experiments utilizing ferric ammonium citrate (FAC) conducted establish model rat liver-derived BRL-3A cells. result found FAC can increase cell’s Fe2+ content 0.05), ROS 0.01), lipid 0.01) levels, expression gene protein aligning findings. inhibition decrease vitality promote thus aggravating FAC-induced Using agonist cobalt protoporphyrin (CoPP) induce overexpression alleviate viability 0.01). addition, siLnc286.2 expression, decline activity, content. conclusion, findings study suggest suppressing Lnc286.2, we enhance HO-1, turn alleviates peroxidation cells increases their antioxidant capacity, thereby exerting protective effect against induced overload.

Language: Английский

Citations

0
Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer DOI
Elena G. Varlamova

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127620 - 127620

Published: Feb. 14, 2025

Language: Английский

Citations

0
Anticancer signal transduction pathways of selenium nanoparticles in mouse colorectal cancer model. DOI
Elena G. Varlamova, Sergey V. Gudkov, Е.В. Блинова

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 769, P. 151962 - 151962

Published: May 7, 2025

Language: Английский

Citations

0
Differential effect of cerium nanoparticles on the viability, redox-status and Ca2+-signaling system of cancer cells of various origins. DOI
Е. Г. Варламова, Sergey V. Gudkov, Egor A. Turovsky

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 764, P. 110261 - 110261

Published: Dec. 5, 2024

Language: Английский

Citations

2