Complex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117803 - 117803

Published: Jan. 2, 2025

Language: Английский

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Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1715 - 1740

Published: Jan. 2, 2025

Chronic liver diseases, primarily metabolic dysfunction-associated steatotic disease (MASLD), and alcoholic (MetALD), viral hepatitis, can lead to fibrosis, cirrhosis, cancer. Hepatic stellate cell (HSC) activation plays a central role in the development of myofibroblasts fibrogenesis chronic diseases. However, HSC is influenced by complex microenvironments within liver, which are largely shaped interactions between HSCs various other types. Changes phenotypes mechanisms involve glucose, lipid, cholesterol metabolism, oxidative stress, unfolded protein response (UPR), autophagy, ferroptosis, senescence, nuclear receptors. Clinical interventions targeting these pathways have shown promising results addressing inflammation as well modulating glucose lipid metabolism stress responses. Therefore, comprehensive understanding presents opportunities for novel therapeutic approaches aimed at halting or even reversing

Language: Английский

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Biological Clock Perspective in Rheumatoid Arthritis

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 10, 2024

Language: Английский

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Obesity alters circadian and behavioral responses to constant light in male mice

Physiology & Behavior, Journal Year: 2024, Volume and Issue: 287, P. 114711 - 114711

Published: Oct. 11, 2024

Language: Английский

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Circadian Rhythms, Immune Regulation and the Risk for Sepsis

Clinics in Perinatology, Journal Year: 2024, Volume and Issue: 52(1), P. 185 - 197

Published: Nov. 26, 2024

Language: Английский

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