Cited by Metabolic fate of the natural anticancer agent cucurbitacin B: an LC–MS/MS-enabled profiling of its major phase I and II conjugates in vivo

Autophagy and Programmed Cell Death Modalities Interplay in HIV Pathogenesis DOI

Harpreet Kaur Lamsira,

Andrea Sabatini, Serena Ciolfi

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 351 - 351

Published: Feb. 28, 2025

Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according the Joint United Nations Program on HIV/AIDS (UNAIDS) at end of 2021 with 1.5 new infections. New HIV infections increased during 2 years after COVID-19 pandemic. Understanding intricate cellular processes underlying pathogenesis is crucial for developing effective therapeutic strategies. Among these processes, autophagy and programmed cell death modalities, including apoptosis, necroptosis, pyroptosis, ferroptosis, play pivotal roles in host-virus interaction dynamics. Autophagy, highly conserved mechanism, acts as double-edged sword infection, influencing viral replication, immune response modulation, fate infected cells. Conversely, critical defense mechanism against spread contributes depletion CD4+ T cells, hallmark progression. This review aims dissect complex interplay between modalities HIV-induced pathogenesis. It highlights molecular mechanisms involved, their persistence dysfunction, challenges posed by reservoir drug resistance, which continue impede management pathology. Targeting pathways holds promise novel strategies mitigate chronic inflammation, ultimately improving outcomes individuals living HIV.

Language: Английский

Citations

Hesperetin inhibits Siniperca chuatsi rhabdovirus replication by reducing mitochondrial apoptosis in EPC cells DOI

Zhenyu Ma,

Shuangshuang Sun,

Shiwei Ma

et al.

Israeli Journal of Aquaculture - Bamidgeh, Journal Year: 2025, Volume and Issue: 77(1)

Published: March 20, 2025

Hesperetin is one of the natural dihydroflavonoid widely extracted from various plants, and a large number studies have demonstrated that hesperetin has wide range biological activities. In this study, we explored its antiviral function against Siniperca chuatsi rhabdovirus (SCRV), strain important fish viral viruses, resulting in multiple transmissions devastating damage aquaculture. Experiments were performed to confirm could effectively delay occurrence cytopathic effects (CPEs) epithelioma papulosum cyprinid cells (EPC), inhibit SCRV replication by microscopy observation titer assay, respectively. Time-of-addition assay showed best inhibitory effect was achieved blocking invasion into cells. addition, qRT-PCR western blot analysis confirmed significantly expression nucleoprotein. Flow cytometry reduce SCRV-inducing apoptosis EPC after annexin V-FITC/PI double staining immunofluorence JC-1 incubation. Down-regulation caspase-3 caspase-9 enzymatic activity treatment indicated it might protect infection decreasing mitochondrial intrinsic infected After treatment, decrease ROS an increase membrane potential (MMP) SCRV-infected further inhibition apoptotic pathway mediated hesperetin. Thus, our present study possessed ability SCRV, suggesting candidate role for effective control spreading.

Language: Английский

Citations

Selective Autophagy Mediated by Protein Ubiquitination in Major Prevalent Zoonoses DOI

Chi Meng,

Fengyuan Jiao,

Gengxu Zhou

et al.

Transboundary and Emerging Diseases, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Zoonotic diseases not only cause great harm to animal health but also involve the development of husbandry, which in turn endangers human life and public safety. Protein ubiquitination autophagy are important ways for body degrade invading pathogens, correspond ubiquitin (Ub)‐proteasome system (UPS) autophagic lysosomal pathway (ALP), respectively, play an role occurrence diseases. For UPS, substrate is delivered 26S proteasome via a cascade subsequently degraded removed. ALP, encapsulated form autophagosomes, fuse with lysosomes autophagolysosomes, eventually cleared. However, variety zoonotic pathogens can interfere protein process promote self‐replication survival, resist host immune defense. This article reviews mechanisms by multiple degradation pathways, providing new perspective treatment prevention

Language: Английский

Citations

Non-coding RNA as a key regulator and novel target of apoptosis in diabetic cardiomyopathy: Current status and future prospects DOI

Yicheng Liu, Jie Yuan, Yuhang Zhang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 128, P. 111632 - 111632

Published: Feb. 6, 2025

Language: Английский

Citations

Deciphering Biofilm Formation in Veterinary Pathogens: Unveiling Insights Through Proteomics Analysis DOI

Anati Abd Rashid Syaida,

Mohd Taufiq Mat Jalil, Shafiq Aazmi

et al.

Livestock diseases and management, Journal Year: 2025, Volume and Issue: unknown, P. 447 - 471

Published: Jan. 1, 2025

Language: Английский

Citations

Carboplatin restricts peste des petits ruminants virus replication by suppressing the STING-mediated autophagy DOI

Rui Zhang, Zhanying Hu,

Dingcheng Wei

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: May 15, 2024

Peste des petits ruminants virus (PPRV) is a morbillivirus that causes the acute and highly pathogenic infectious disease peste (PPR) in small poses major threat to goat sheep industries. Currently, there no effective treatment for PPRV infection. Here, we propose Carboplatin, platinum-based regimen designed treat range of malignancies, as potential antiviral agent. We showed Carboplatin exhibits significant activity against cell culture model. The mechanism action mainly attributed its ability block STING mediated autophagy. Together, our study supports discovery an potentially other closely related viruses, sheds light on mode action, establishes valid attractive target counteract viral

Language: Английский

Citations

Role of Neurotropic Viruses in Brain Metastasis of Breast Cancer: Mechanisms and Therapeutic Implications DOI

Ziran Qiu,

Xinyu Liu, Wenqing Cao

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Sept. 1, 2024

ABSTRACT Neurotropic viruses have been implicated in altering the central nervous system microenvironment and promoting brain metastasis of breast cancer through complex interactions involving viral entry mechanisms, modulation blood–brain barrier, immune evasion, alteration tumour microenvironment. This narrative review explores molecular mechanisms by which neurotropic such as Herpes Simplex Virus, Human Immunodeficiency Japanese Encephalitis Rabies Virus facilitate metastasis, focusing on their ability to disrupt barrier integrity, modulate responses, create a permissive environment for metastatic cell survival growth within system. Current therapeutic implications challenges targeting prevent or treat are discussed, highlighting need innovative strategies multidisciplinary approaches virology, oncology, immunology.

Language: Английский

Citations

Metabolic fate of the natural anticancer agent cucurbitacin B: an LC–MS/MS-enabled profiling of its major phase I and II conjugates in vivo DOI

Wenya Liu,

Di Xu,

Huihui Meng

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(29), P. 7043 - 7062

Published: Oct. 23, 2024

Language: Английский

Citations