International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12495 - 12495
Published: Nov. 21, 2024
An
abdominal
aortic
aneurysm
(AAA)
is
described
as
a
gradual
and
localized
permanent
expansion
of
the
aorta
resulting
from
weakening
vascular
wall.
The
key
aspects
AAA's
progression
are
high
proteolysis
structural
elements
wall,
depletion
smooth
muscle
cells
(VSMCs),
chronic
immunoinflammatory
response.
pathological
mechanisms
underpinning
development
an
AAA
complex
still
unknown.
At
present,
there
no
successful
drug
treatments
available
that
can
slow
or
prevent
rupture
aneurysmal
Recently,
it
has
been
suggested
endothelial
cellular
senescence
may
be
involved
in
aging
diseases,
but
clear
correlation
between
AAAs.
Therefore,
aim
this
study
was
to
identify
presence
senescent
on
wall
aneurysmatic
aortas
correlate
their
distribution
with
morphological
markers
Pathological
healthy
segments
were
collected
during
repair
surgery
immediately
processed
for
histological
immunohistochemical
analyses.
Hematoxylin/eosin,
Verhoeff-van
Gieson,
Goldner's
Masson
trichrome
staining
procedures
carried
out
investigate
features
related
pathology.
Immunohistochemical
investigations
p21
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: May 13, 2024
Cardiovascular
diseases
(CVD)
are
the
leading
cause
of
death
worldwide,
despite
advances
in
understanding
cardiovascular
health.
Significant
barriers
still
exist
effectively
preventing
and
managing
these
diseases.
Vascular
smooth
muscle
cells
(VSMCs)
crucial
for
maintaining
vascular
integrity
can
switch
between
contractile
synthetic
functions
response
to
stimuli
such
as
hypoxia
inflammation.
These
transformations
play
a
pivotal
role
progression
diseases,
facilitating
modifications
disease
advancement.
This
article
synthesizes
current
mechanisms
signaling
pathways
regulating
VSMC
phenotypic
transitions,
highlighting
their
potential
therapeutic
targets
interventions.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e41906 - e41906
Published: Jan. 23, 2025
The
aim
of
this
study
was
to
systematically
investigate
the
effects
and
mechanisms
Rhubarb
in
treatment
Atherosclerosis
(AS)
Abdominal
Aortic
Aneurysm
(AAA)
by
utilizing
network
pharmacology
molecular
docking
techniques.
TCMSP
systematic
database
utilized
search
for
active
chemical
components
Rhubarb.
Disease-related
targets
were
retrieved
from
GEO
dataset
Disgenet
database.
Gene
interactions
identify
common
with
AS/AAA,
interaction
networks
constructed
using
Cytoscape
3.9.1.
Protein-protein
(PPI)
core
STRING
GO
KEGG
pathway
enrichment
analysis
performed
DAVID.
Molecular
is
used
assess
potential
target-active
compound
interactions.
In
our
study,
16
compounds
screened
Rhubarb,
along
310
targets.
Additionally,
110
AS/AAA
target
genes
out.
Topological
PPI
protein
yielded
23
targets,
biological
functions
signaling
pathways
further
investigated.
indicated
that
may
be
effective
treating
through
processes
such
as
lipids,
atherosclerosis,
extracellular
matrix
catabolism,
collagenolytic
metabolic
processes,
environment.
Five
pharmacological
also
identified:
TNF,
IL-1β
MMP9,
TP53,
PPARG.
showed
a
strong
binding
ability
between
This
successfully
predicted
functions,
associated
AS/AAA.
addition,
identified
ingredients
can
source
drug
screening.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2067 - 2067
Published: Feb. 27, 2025
Cardiovascular
diseases
remain
a
leading
cause
of
morbidity
and
mortality
worldwide,
with
aneurysmal
standing
out
as
particularly
insidious
threats
[...].
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
138, P. 112608 - 112608
Published: July 8, 2024
Abdominal
aortic
aneurysm
(AAA)
poses
a
significant
health
risk
and
is
influenced
by
various
compositional
features.
This
study
aimed
to
develop
an
artificial
intelligence-driven
multiomics
predictive
model
for
AAA
subtypes
identify
heterogeneous
immune
cell
infiltration
predict
disease
progression.
Additionally,
we
investigated
neutrophil
heterogeneity
in
patients
with
different
elucidate
the
relationship
between
microenvironment
pathogenesis.
Ovarian
cancer
(OC)
represents
a
significant
challenge
in
the
realm
of
gynecological
cancers,
characterized
by
poor
survival
rates
and
complex
etiology.
In
this
review,
we
delve
into
se-lected
genetic,
environmental,
hormonal
factors
underpinning
OC
development.
We
have
reviewed
scientific
databases
searching
for
ovarian
genetic
epigenetic
factors.
included
studies
based
on
their
relevancy.
As
result
exploring
carcinogen-esis,
systematic
review
contains
data
collected
from
126
various
works.
The
role
prominent
players
such
as
BRCA
mutations,
DNA
repair
mechanisms,
un-derscores
intricate
landscape
susceptibility.
explore
Li-Fraumeni
Lynch
syn-drome,
which
impart
heightened
predisposition
to
Hormonal
estrogen,
progesterone,
androgens
are
also
discussed.
Environmental
alterations,
ranging
lifestyle
influences
microbiome
dysbiosis
obesity,
al-cohol
consumption,
physical
activity
intersect
with
pathways,
shaping
risk
OC.
Through
meticulous
examination
current
literature,
provides
nuanced
under-standing
multifactorial
nature
OC,
emphasizing
need
holistic
approaches
prevention,
diagnosis,
treatment.
Academic Radiology,
Journal Year:
2024,
Volume and Issue:
31(9), P. 3837 - 3843
Published: April 17, 2024
RationaleThe
pulmonary
artery
(PA)
diameter-to-aorta
ratio
(PA:A)
is
a
novel
marker
in
cardiovascular
imaging
for
detecting
hypertension.
However,
we
question
the
effect
of
varying
aorta
diameter
on
ratio,
which
complicates
interpretation
PA:A
ratio.ObjectiveInvestigate
variability
by
examining
correlation
between
and
comparing
associations
PA
diameter,
diameters,
ratio.MethodsWe
included
2197
participants
from
Rotterdam
Study
who
underwent
non-contrast
multidetector
computed
tomography
to
measure
diameters.
Pearson
coefficient
was
calculated
diameter.
Multiple
linear
regression
analyses
were
performed
compare
determinants
individual
diameters
ratio.ResultsWe
found
statistically
significant
(r
=
−0.38,
p
<
0.001).
The
significantly
associated
with,
height,
weight,
diastolic
blood
pressure,
pressure
medication,
prevalence
atrial
fibrillation,
heart
failure,
stroke
(p
0.05).
Except
had
similar
compared
but
also
with
sex,
systolic
0.05),
0.05).ConclusionThe
should
not
be
interpreted
without
taking
into
account
components
(PA
diameter)
according
anthropomorphic
clinical
characteristics.
ratio.
Investigate
We
Aging,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Precursor
T-cell
acute
lymphoblastic
leukemia
(Pre-T
ALL)
is
a
malignant
neoplastic
disease
in
which
T-cells
proliferate
the
bone
marrow.
Single-cell
sequencing
technology
could
identify
characteristic
cell
types,
facilitating
study
of
therapeutic
mechanisms
Pre-T
ALL.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
ABSTRACT
Introduction
Intracranial
aneurysm
(IA)
frequently
coincides
with
autosomal
dominant
polycystic
kidney
disease
(ADPKD),
exhibiting
incidence
rates
nearly
10
times
higher
than
the
general
population.
However,
exact
mechanism
of
how
these
two
conditions
is
related
remains
unclear.
This
study
aims
to
identify
mechanisms
behind
IA
occurrence
in
ADPKD
patients
using
proteomics
and
discover
potential
protein
biomarkers
for
early
diagnosis.
Method
Pre-kidney
transplantation
underwent
cranial
CT
and/or
MR
angiography,
findings
dictating
assignment
either
a
control
group
(ADPKD
without
IA,
n=20)
or
n=9).
During
transplantation,
bilateral
nephrectomy
was
performed
native
renal
arteries
were
sampled
proteomic
analysis
via
liquid
chromatography-tandem
mass
spectrometry.
Differentially
expressed
proteins
subjected
bioinformatic
protein-protein
interaction
network
analysis.
Results
Eight
showed
significant
variation
between
groups,
four
upregulated
(DIS3,
RAB6A,
MMS19,
EXOC8)
downregulated
(CLUH,
SYNC,
MEF2D,
WDR36)
(Log
2
fold
change
(FC)
>2
false
discovery
rate
(FDR]
q-value
<0.05)
compared
group.
These
correlated
pathways
implicated
development,
such
as
ciliopathy,
exocytosis,
inflammation,
extracellular
matrix
remodelling,
apoptosis.
quantitatively
validated
Western
blot
found
be
consistent
data.
Moreover,
connection
observed
expression
clinical
metrics
(bilirubin,
prothrombin
time,
platelet
count),
indicating
their
diagnostic
markers.
Conclusion
first
employ
artery
samples
underlying
by
proteomics.
We
identified
novel
candidate
markers
that
are
research’s
finding
opens
new
avenues
understanding
diagnosing
ADPKD,
potentially
leading
earlier
diagnosis
targeted
treatments.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 17, 2024
Abstract
Background
The
pathogenesis
of
aortic
aneurysm
(AA)
remains
unclear,
and
there
are
no
effective
therapeutic
drugs
or
targets.
Circulating
plasma
proteins
considered
biomarkers
AA
potential
targets
for
AA.
This
study
aimed
to
systematically
evaluate
the
causal
effects
on
using
a
multi-cohort
Mendelian
randomization
(MR)
approach.
Methods
Protein
quantitative
trait
loci
(pQTLs)
was
obtained
from
9
published
proteome
genome-wide
association
studies
(GWAS)
GWAS
data
FinnGen
cohort.
Independent
pQTLs
were
selected
as
instrumental
variables
(IVs).
Two-sample
MR
analysis
performed
inverse-variance
weighted,
MR-Egger
regression,
weighted
median,
mode,
simple
mode
methods.
Heterogeneity
pleiotropy
assessed
Cochran’s
Q
test,
I²
statistic,
intercept,
MR-PRESSO,
Leave-one-out
analysis.
Steiger
filtering
used
test
direction.
Colocalization
pQTL-eQTL
overlap
assessment
conducted
validate
findings.
Pathway
enrichment
drug
target
analyses
explore
biological
clinical
implications
results.
Results
A
total
8,285
4,421
retained
IVs.
Using
cis-pQTLs
IVs,
identified
154
causally
associated
with
TAA
(76
protective
factors
78
risk
factors)
211
AAA
(112
99
factors).
cis-pQTLs+trans-pQTLs
236
(113
123
309
(143
166
results
showed
significant
heterogeneity
pleiotropy.
confirmed
direction
circulating
found
evidence
shared
variants
between
multiple
majority
AA-associated
had
overlapping
blood
eQTLs
proxy
eQTLs.
revealed
that
these
involved
in
stress
response,
immune
regulation,
cytokine-cytokine
receptor
interaction,
metabolic
processes
so
on.
Nearly
two-thirds
related
classified
druggable
potentially
Conclusions
large
number
novel
pathogenic
AA,
providing
important
references
elucidating
molecular
advancing
development.