Vascular Mesenchymal Stromal Cells and Cellular Senescence: A Two-Case Study Investigating the Correlation Between an Inflammatory Microenvironment and Abdominal Aortic Aneurysm Development DOI Open Access
Gabriella Teti,

Riccardo Camiletti,

Valentina Gatta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12495 - 12495

Published: Nov. 21, 2024

An abdominal aortic aneurysm (AAA) is described as a gradual and localized permanent expansion of the aorta resulting from weakening vascular wall. The key aspects AAA's progression are high proteolysis structural elements wall, depletion smooth muscle cells (VSMCs), chronic immunoinflammatory response. pathological mechanisms underpinning development an AAA complex still unknown. At present, there no successful drug treatments available that can slow or prevent rupture aneurysmal Recently, it has been suggested endothelial cellular senescence may be involved in aging diseases, but clear correlation between AAAs. Therefore, aim this study was to identify presence senescent on wall aneurysmatic aortas correlate their distribution with morphological markers Pathological healthy segments were collected during repair surgery immediately processed for histological immunohistochemical analyses. Hematoxylin/eosin, Verhoeff-van Gieson, Goldner's Masson trichrome staining procedures carried out investigate features related pathology. Immunohistochemical investigations p21

Language: Английский

Extracellular matrix in vascular homeostasis and disease DOI
Lu Zhang, Jing Zhou, Wei Kong

et al.

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

1
Elucidating VSMC phenotypic transition mechanisms to bridge insights into cardiovascular disease implications DOI

Yuning Xin,

Zipei Zhang,

Shan Lv

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 13, 2024

Cardiovascular diseases (CVD) are the leading cause of death worldwide, despite advances in understanding cardiovascular health. Significant barriers still exist effectively preventing and managing these diseases. Vascular smooth muscle cells (VSMCs) crucial for maintaining vascular integrity can switch between contractile synthetic functions response to stimuli such as hypoxia inflammation. These transformations play a pivotal role progression diseases, facilitating modifications disease advancement. This article synthesizes current mechanisms signaling pathways regulating VSMC phenotypic transitions, highlighting their potential therapeutic targets interventions.

Language: Английский

Citations

6
Network Pharmacology and Molecular Analysis of Mechanisms underlying the therapeutic effects of Rhubarb in treating Atherosclerosis and Abdominal Aortic Aneurysm DOI Creative Commons
Huilin Xu, Jun Huang, Youjie Zeng

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e41906 - e41906

Published: Jan. 23, 2025

The aim of this study was to systematically investigate the effects and mechanisms Rhubarb in treatment Atherosclerosis (AS) Abdominal Aortic Aneurysm (AAA) by utilizing network pharmacology molecular docking techniques. TCMSP systematic database utilized search for active chemical components Rhubarb. Disease-related targets were retrieved from GEO dataset Disgenet database. Gene interactions identify common with AS/AAA, interaction networks constructed using Cytoscape 3.9.1. Protein-protein (PPI) core STRING GO KEGG pathway enrichment analysis performed DAVID. Molecular is used assess potential target-active compound interactions. In our study, 16 compounds screened Rhubarb, along 310 targets. Additionally, 110 AS/AAA target genes out. Topological PPI protein yielded 23 targets, biological functions signaling pathways further investigated. indicated that may be effective treating through processes such as lipids, atherosclerosis, extracellular matrix catabolism, collagenolytic metabolic processes, environment. Five pharmacological also identified: TNF, IL-1β MMP9, TP53, PPARG. showed a strong binding ability between This successfully predicted functions, associated AS/AAA. addition, identified ingredients can source drug screening.

Language: Английский

Citations

0
Molecular Insights into Cardiovascular Disease: Unraveling Pathways for Diagnosis and Treatment DOI Open Access
Dai Yamanouchi

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2067 - 2067

Published: Feb. 27, 2025

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, with aneurysmal standing out as particularly insidious threats [...].

Language: Английский

Citations

0
Artificial intelligence-driven multiomics predictive model for abdominal aortic aneurysm subtypes to identify heterogeneous immune cell infiltration and predict disease progression DOI Creative Commons
Lin Zhang, Yang Han,

Chenxing Zhou

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112608 - 112608

Published: July 8, 2024

Abdominal aortic aneurysm (AAA) poses a significant health risk and is influenced by various compositional features. This study aimed to develop an artificial intelligence-driven multiomics predictive model for AAA subtypes identify heterogeneous immune cell infiltration predict disease progression. Additionally, we investigated neutrophil heterogeneity in patients with different elucidate the relationship between microenvironment pathogenesis.

Language: Английский

Citations

1
Most Relevant Genetic, Hormonal, and Environmental Factors in Ovarian Cancer Development – A Literature Review DOI Open Access

Alicja Florczak,

Aleksandra Królikowska, Mateusz Mazurek

et al.

Published: May 21, 2024

Ovarian cancer (OC) represents a significant challenge in the realm of gynecological cancers, characterized by poor survival rates and complex etiology. In this review, we delve into se-lected genetic, environmental, hormonal factors underpinning OC development. We have reviewed scientific databases searching for ovarian genetic epigenetic factors. included studies based on their relevancy. As result exploring carcinogen-esis, systematic review contains data collected from 126 various works. The role prominent players such as BRCA mutations, DNA repair mechanisms, un-derscores intricate landscape susceptibility. explore Li-Fraumeni Lynch syn-drome, which impart heightened predisposition to Hormonal estrogen, progesterone, androgens are also discussed. Environmental alterations, ranging lifestyle influences microbiome dysbiosis obesity, al-cohol consumption, physical activity intersect with pathways, shaping risk OC. Through meticulous examination current literature, provides nuanced under-standing multifactorial nature OC, emphasizing need holistic approaches prevention, diagnosis, treatment.

Language: Английский

Citations

1
Revisiting the Clinical Interpretation of CT-Measured Pulmonary Artery-to-Aorta Ratio—The Rotterdam Study DOI Creative Commons

Cyrus Khan,

M. Kamran Ikram,

Natalie Terzikhan

et al.

Academic Radiology, Journal Year: 2024, Volume and Issue: 31(9), P. 3837 - 3843

Published: April 17, 2024

RationaleThe pulmonary artery (PA) diameter-to-aorta ratio (PA:A) is a novel marker in cardiovascular imaging for detecting hypertension. However, we question the effect of varying aorta diameter on ratio, which complicates interpretation PA:A ratio.ObjectiveInvestigate variability by examining correlation between and comparing associations PA diameter, diameters, ratio.MethodsWe included 2197 participants from Rotterdam Study who underwent non-contrast multidetector computed tomography to measure diameters. Pearson coefficient was calculated diameter. Multiple linear regression analyses were performed compare determinants individual diameters ratio.ResultsWe found statistically significant (r = −0.38, p < 0.001). The significantly associated with, height, weight, diastolic blood pressure, pressure medication, prevalence atrial fibrillation, heart failure, stroke (p 0.05). Except had similar compared but also with sex, systolic 0.05), 0.05).ConclusionThe should not be interpreted without taking into account components (PA diameter) according anthropomorphic clinical characteristics. ratio. Investigate We

Language: Английский

Citations

0
Single-cell sequencing technology to characterize stem T-cell subpopulations in acute T-lymphoblastic leukemia and the role of stem T-cells in the disease process DOI Creative Commons
Yan Li, Zhenwei Jia, Xiaoyan Liu

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Precursor T-cell acute lymphoblastic leukemia (Pre-T ALL) is a malignant neoplastic disease in which T-cells proliferate the bone marrow. Single-cell sequencing technology could identify characteristic cell types, facilitating study of therapeutic mechanisms Pre-T ALL.

Language: Английский

Citations

0
Exploring the Molecular Pathways of Intracranial Aneurysm Formation in Autosomal Dominant Polycystic Kidney Disease Using Proteomic Analysis DOI Creative Commons
Jin-Myung Kim, Hee‐Sung Ahn, Mi Joung Kim

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

ABSTRACT Introduction Intracranial aneurysm (IA) frequently coincides with autosomal dominant polycystic kidney disease (ADPKD), exhibiting incidence rates nearly 10 times higher than the general population. However, exact mechanism of how these two conditions is related remains unclear. This study aims to identify mechanisms behind IA occurrence in ADPKD patients using proteomics and discover potential protein biomarkers for early diagnosis. Method Pre-kidney transplantation underwent cranial CT and/or MR angiography, findings dictating assignment either a control group (ADPKD without IA, n=20) or n=9). During transplantation, bilateral nephrectomy was performed native renal arteries were sampled proteomic analysis via liquid chromatography-tandem mass spectrometry. Differentially expressed proteins subjected bioinformatic protein-protein interaction network analysis. Results Eight showed significant variation between groups, four upregulated (DIS3, RAB6A, MMS19, EXOC8) downregulated (CLUH, SYNC, MEF2D, WDR36) (Log 2 fold change (FC) >2 false discovery rate (FDR] q-value <0.05) compared group. These correlated pathways implicated development, such as ciliopathy, exocytosis, inflammation, extracellular matrix remodelling, apoptosis. quantitatively validated Western blot found be consistent data. Moreover, connection observed expression clinical metrics (bilirubin, prothrombin time, platelet count), indicating their diagnostic markers. Conclusion first employ artery samples underlying by proteomics. We identified novel candidate markers that are research’s finding opens new avenues understanding diagnosing ADPKD, potentially leading earlier diagnosis targeted treatments.

Language: Английский

Citations

0
Causal Effect of Multi-cohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization Study DOI Creative Commons
Yuan Zheng,

Qin Lin,

Jiayu Ji

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 17, 2024

Abstract Background The pathogenesis of aortic aneurysm (AA) remains unclear, and there are no effective therapeutic drugs or targets. Circulating plasma proteins considered biomarkers AA potential targets for AA. This study aimed to systematically evaluate the causal effects on using a multi-cohort Mendelian randomization (MR) approach. Methods Protein quantitative trait loci (pQTLs) was obtained from 9 published proteome genome-wide association studies (GWAS) GWAS data FinnGen cohort. Independent pQTLs were selected as instrumental variables (IVs). Two-sample MR analysis performed inverse-variance weighted, MR-Egger regression, weighted median, mode, simple mode methods. Heterogeneity pleiotropy assessed Cochran’s Q test, I² statistic, intercept, MR-PRESSO, Leave-one-out analysis. Steiger filtering used test direction. Colocalization pQTL-eQTL overlap assessment conducted validate findings. Pathway enrichment drug target analyses explore biological clinical implications results. Results A total 8,285 4,421 retained IVs. Using cis-pQTLs IVs, identified 154 causally associated with TAA (76 protective factors 78 risk factors) 211 AAA (112 99 factors). cis-pQTLs+trans-pQTLs 236 (113 123 309 (143 166 results showed significant heterogeneity pleiotropy. confirmed direction circulating found evidence shared variants between multiple majority AA-associated had overlapping blood eQTLs proxy eQTLs. revealed that these involved in stress response, immune regulation, cytokine-cytokine receptor interaction, metabolic processes so on. Nearly two-thirds related classified druggable potentially Conclusions large number novel pathogenic AA, providing important references elucidating molecular advancing development.

Language: Английский

Citations

0