Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Abstract
IRE1α,
a
type
I
transmembrane
protein
characterized
by
cytoplasmic
serine/threonine
kinase
domain,
is
related
to
ER
stress
and
function
maintenance.
In
this
study,
4µ8c,
highly
effective
selective
inhibitor
of
IRE1α
RNase,
APY29,
an
ATP
competitive
inhibitor,
inhibiting
autophosphorylation
the
were
employed
elucidate
on
proliferation
ovarian
granulosa
cells,
with
ultimate
goal
identifying
novel
strategies
methodologies
for
prevention
treatment
associated
diseases.
Human
cells
(SVOG)
cultured
in
vitro
treated
inhibitors
4µ8c
APY29.
It
was
shown
that
inhibition
reduced
cell
ability
dealing
misfolded
protein,
triggered
oxidative
stress,
altered
mitochondrial
membrane
potential,
inflicted
DNA
damage,
eventually
lead
apoptosis.
Discover Sustainability,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Aug. 8, 2024
Abstract
This
review
explores
the
therapeutic
potential
of
propolis,
a
natural
resin
produced
by
bees,
analyzing
recent
literature
spanning
from
2005
to
2023.
Various
databases
including
Google
Scholar,
Web
Science,
Science
Direct,
PubMed,
SCOPUS,
and
WoS
were
searched
uncover
findings.
Propolis
exhibits
diverse
array
pharmacological
properties,
antimicrobial,
anti-inflammatory,
antioxidant,
immunomodulatory,
wound-healing
effects.
It
shows
promise
in
treating
respiratory
infections,
oral
diseases,
gastrointestinal
disorders,
skin
conditions.
Additionally,
research
suggests
its
as
an
anticancer
agent.
The
also
investigates
efficacy
propolis
addressing
antiviral,
antibacterial,
metabolic
disorders
(diabetes),
reproductive
disorder
(PCOS),
cardiovascular
hepatotoxicity,
wound
healing
properties
propolis.
Hence,
could
emerge
remedy
with
significant
for
enhancing
healthcare
outcomes.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(8), P. 1672 - 1672
Published: April 8, 2025
Parkinson's
disease
(PD)
is
a
complex
neurodegenerative
disorder
with
debilitating
non-motor
symptoms,
including
gastrointestinal
dysfunction,
cardiovascular
abnormalities,
mood
and
anxiety
disorders,
cognitive
decline,
sleep
disturbances,
respiratory
pain.
Despite
their
significant
impact
on
quality
of
life,
these
symptoms
are
often
inadequately
addressed.
Propolis
natural
bee-derived
product,
rich
in
bioactive
compounds
anti-inflammatory,
antioxidant,
immunomodulatory,
neuroprotective
properties,
which
holds
potential
PD
due
to
its
multitarget
multipathway
actions,
addressing
various
underlying
mechanisms
symptom
diseases.
Preclinical
clinical
studies
suggest
that
propolis
may
influence
key
pathological
PD's
symptoms.
Evidence
points
benefits
improving
cognition,
health,
alleviating
sleep-related
issues.
Although
research
remains
scarce,
findings
from
related
conditions
ability
associated
This
review
underscores
the
underexplored
therapeutic
PD,
drawing
existing
evidence
advocating
for
further
fully
assess
role
patient
outcomes.
ABSTRACT
Doxorubicin
(DOX)
is
the
most
widely
used
chemotherapeutic
agent
to
treat
various
tumors.
DOX
treatment
can
damage
many
organs,
including
brain,
by
causing
oxidative
stress.
Several
antioxidant
substances
lessen
effects
of
or
make
defense
systems
work
faster.
Propolis
(PROP)
a
powerful
with
healing
effects,
antioxidant,
antiproliferative,
and
anti‐inflammatory.
The
point
this
study
look
at
histopathological
changes,
apoptosis,
on
brain
in
rats.
To
find
out
what
kinds
phytochemicals
were
PROP
from
Karlıova
region
Bingöl
province,
ultra‐high‐performance
liquid
chromatography
(UHPLC‐Orbitrap‐HRMS)
was
used.
Then,
we
made
an
ethanol
extract
it.
A
total
28
healthy
male
Wistar
albino
rats,
each
12
weeks
old
weighing
between
220
250
g,
included
study.
Rats
divided
into
four
groups:
control,
PROP,
DOX,
PROP+DOX.
We
applied
relevant
treatments
determined
groups.
Following
application,
decapitated
rats
under
appropriate
conditions
collected
blood
tissue
samples.
examined
stress
parameters
samples
for
histopathological,
biochemical,
molecular
analyses.
levels
using
UHPLC‐Orbitrap‐HRMS.
findings
obtained
showed
that
improved
DOX‐induced
damage.
In
addition,
attenuated
inflammation,
ER
stress,
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: May 12, 2025
Although
a
large
number
of
trials
have
observed
the
anti-inflammatory
properties
propolis,
currently
available
research
remains
controversial
regarding
its
beneficial
health
effects.
Hence,
purpose
this
study
was
to
examine
effect
propolis
on
inflammatory
and
oxidative
stress
markers
in
adults.
A
comprehensive
search
performed
Scopus,
Web
Science,
PubMed/Medline
find
relevant
randomized
controlled
(RCTs)
until
January
2024.
The
overall
sizes
were
calculated
using
random-effects
model
expressed
as
weighted
mean
differences
(WMD)
with
95%
confidence
interval
(CI).
possible
heterogeneity
between
included
assessed
by
performing
Cochran's
Q
test.
In
total,
27
29
treatment
arms
eligible
for
inclusion
review.
This
meta-analysis
revealed
that
consumption
led
significant
decrease
C-reactive
protein
(CRP)
(WMD:
-1.23;
95%CI:
-1.76,
-0.69;
p
<
0.001),
Interleukin-6
(IL-6)
-1.52;
-2.10,
-0.93;
Tumor
necrosis
factor-α
-1.15;
-1.75,
-0.55;
Monocyte
chemoattractant
protein-1
(MCP-1)
-35.33;
-50.28,
-20.37;
increase
total
antioxidant
capacity
(TAC)
0.32;
0.12,
0.51;
=
Glutathione
(GSH)
4.71;
3.17,
6.25;
peroxidase
(GPx)
44.75;
5.10,
84.40;
0.02).
However,
there
no
effects
IL-10,
IL-2,
IL-8,
pro-oxidant-antioxidant
balance
(PAB),
malondialdehyde
(MDA),
superoxide
dismutase
(SOD)
comparison
control
group.
Propolis
supplementation
appears
effective
reducing
inflammation
enhancing
specific
markers.
variations
designs,
dosages,
participant
characteristics
contribute
results.
Further
well-designed
RCTs
are
needed
confirm
these
findings
determine
optimal
dosage
long-term
Given
potential
properties,
may
serve
complementary
approach
managing
inflammation-related
conditions,
though
clinical
application
requires
further
validation.
https://clinicaltrials.gov/,
identifier
CRD42023474033.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: June 4, 2025
IRE1α,
a
type
I
transmembrane
protein
characterized
by
cytoplasmic
serine/threonine
kinase
domain,
is
related
to
ER
stress
and
function
maintenance.
In
this
study,
4µ8c,
highly
effective
selective
inhibitor
of
IRE1α
RNase,
APY29,
an
ATP
competitive
inhibitor,
inhibiting
autophosphorylation
the
were
employed
elucidate
on
proliferation
ovarian
granulosa
cells,
with
ultimate
goal
identifying
novel
strategies
methodologies
for
prevention
treatment
associated
diseases.
Human
cells
(SVOG)
cultured
in
vitro
treated
inhibitors
4µ8c
APY29.
It
was
shown
that
inhibition
reduced
cell
ability
dealing
misfolded
protein,
triggered
oxidative
stress,
altered
mitochondrial
membrane
potential,
inflicted
DNA
damage,
eventually
lead
apoptosis.
Peptide Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 27, 2024
ABSTRACT
Propolis,
a
bee
product,
is
renowned
globally
for
its
diverse
pharmacological
activities
attributed
to
phenolic
compounds,
flavonoids,
and
terpenes.
This
study
aims
identify
the
chemical
compounds
in
Algerian
raw
propolis
evaluate
protective
potential
of
inclusion
complex.
Gas
chromatography–mass
spectrometry
(GC/MS),
differential
scanning
calorimetry
(DSC),
thermogravimetric
analysis
(TGA)
were
used
characterization.
Additionally,
molecular
docking
against
SARS‐COVID‐2
main
proteases
ADMET
profiling
conducted.
The
revealed
α‐pinene
(25.29%–11.04%)
limonene
(22.46%–12.88%)
as
major
components
DSC/TGA
demonstrated
effect
encapsulated
molecules,
with
showing
high
activity
7N5Z,
6LU7,
7E6L,
scores
−5.71,
−5.61,
−5.10
kcal/mol,
respectively.
highlights
constituents
drug
candidates
pandemic.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 122 - 122
Published: Dec. 26, 2024
One
of
the
most
pressing
challenges
facing
society
today
is
rising
prevalence
physical
and
cognitive
frailty.
This
geriatric
condition
makes
older
adults
more
vulnerable
to
disability,
illness,
a
heightened
risk
mortality.
In
this
scenario,
Parkinson’s
disease
(PD)
frailty,
which
share
several
common
characteristics,
are
becoming
increasingly
prevalent
worldwide,
underscoring
urgent
need
for
innovative
strategies.
Nutraceuticals
naturally
occurring
bioactive
compounds
contained
in
foods,
offering
health
benefits
over
above
essential
nutrition.
By
examining
literature
from
past
decade,
review
highlights
how
nutraceuticals
can
act
as
complementary
therapies,
addressing
key
processes,
such
oxidative
stress,
inflammation,
neuroprotection.
Notably,
antioxidant
action
appears
particularly
beneficial
regard
PD
For
instance,
antioxidant-rich
may
mitigate
damage
linked
levodopa
therapy
PD,
potentially
reducing
side
effects
enhancing
treatment
sustainability.
Similarly,
amplify
activity,
muscle
function,
health,
resilience,
thereby
proposes
holistic
approach
integrating
with
exercise,
pharmacotherapy,
lifestyle
adjustments.
It
promises
transform
management
ARD,
prolong
life,
improve
quality
life
well-being
people.
