Management approaches for recurrent or metastatic head and neck squamous cell carcinoma after anti-PD-1/PD-L1 immunotherapy

Cancer Treatment Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102938 - 102938

Published: April 1, 2025

Language: Английский

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The impact of the ATP-binding cassette (ABC) transporter family on multidrug resistance in head and neck tumors

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 21, 2025

Language: Английский

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Targeting fibroblast growth factor receptor (FGFR) with inhibitors in head and neck cancers: Their roles, mechanisms and challenges

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 235, P. 116845 - 116845

Published: March 3, 2025

Language: Английский

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Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(4), P. e011692 - e011692

Published: April 1, 2025

Immunotherapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, with neoadjuvant chemoimmunotherapy showing promising pathological complete response rates (36–42%). Lin et al introduce a radiomics-clinical nomogram using MRI-derived intratumoral peritumoral features to predict pCR, addressing critical clinical gap. Their model, emphasizing the region (within 3 mm), achieved high predictive accuracy area under curve (AUC) >0.8. While multicenter design enhances generalizability, standardizing imaging protocols remains challenge. Integrating radiomics Neck Imaging Reporting Data System could refine post-treatment assessment. This study advances precision oncology in HNSCC, offering non-invasive tool for personalized treatment strategies. Future directions include artificial intelligence-driven radiogenomics enhance prediction patient selection.

Language: Английский

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Current nano drug delivery systems for targeting head and neck squamous cell carcinoma microenvironment: a narrative review

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 8, 2025

Language: Английский

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Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 22, 2025

The treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC) has traditionally relied on a multimodal approach, combining surgery, radiation therapy (RT), chemotherapy. While chemotherapy plays critical role in improving cure rates functional outcomes, its substantial toxicity remains major concern, particularly older patients. These challenges are especially relevant for those who unfit or decline conventional concurrent chemoradiotherapy (CCRT), highlighting the need alternative therapeutic options. Many patients at high risk severe side effects, often preventing them from completing full regimen. This review explores strategies to definitive CCRT carcinomas larynx, hypopharynx oropharynx, aiming optimize outcomes while minimizing toxicity. We discuss altered fractionation as promising RT, offering balance between efficacy quality life. Additionally, we examine emerging approaches, including targeted therapies, immunotherapy, hyperthermia, photodynamic nanoparticle-based treatments with which provide complementary options traditional therapies management LA-HNSCC.

Language: Английский

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Dendritic cell-related hub genes in head-and-neck squamous cell carcinoma: implications for prognosis and immunotherapy

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(7), P. 3620 - 3636

Published: July 1, 2024

In the context of head-and-neck squamous cell carcinoma (HNSCC), dendritic cells (DCs) assume pivotal responsibilities, acting as architects antigen presentation and conductors immune checkpoint modulation. this study, we aimed to identify hub genes associated with DCs in HNSCC explore their prognostic significance implications for immunotherapy.

Language: Английский

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Unveiling therapeutic avenues targeting xCT in head and neck cancer

Cellular Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

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A Digital Workflow for Automated Assessment of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma Using QuPath and a StarDist-Based Model

Pathologica, Journal Year: 2024, Volume and Issue: 116(6), P. 390 - 403

Published: Dec. 1, 2024

The search for reliable prognostic markers in oral squamous cell carcinoma (OSCC) remains a critical need. Tumor-infiltrating lymphocytes (TILs), particularly T lymphocytes, play pivotal role the immune response against tumors and are strongly correlated with favorable prognoses. Computational pathology has proven highly effective histopathological image analysis, automating tasks such as detection, classification, segmentation.

Language: Английский

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Emerging therapeutic targets in oral squamous cell carcinoma: Insights from genetic alterations

Oral Oncology Reports, Journal Year: 2024, Volume and Issue: 10, P. 100548 - 100548

Published: June 1, 2024

• EGFR overexpression in OSCC drives tumor growth and metastasis, highlighting its potential as a therapeutic target. TP53 mutations disrupt cell cycle regulation OSCC, fueling oncogenesis treatment resistance. Dysregulation of the PI3K/AKT/mTOR pathway promotes survival proliferation. Immunotherapy shows promise particularly patients with high mutational burden or PD-L1 expression. Genetic profiling tumors may guide personalized strategies for improved patient outcomes.

Language: Английский

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