Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic Homeostasis DOI Creative Commons

Zhaoyu Yang,

Jiaxuan Zhang,

Qiongyu Yuan

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1432 - 1432

Published: Nov. 21, 2024

Oxidative stress is a crucial factor contributing to ovarian follicular atresia and an imbalance in energy metabolism poultry, leading decreased laying performance aging hens. This study aimed investigate the effects of natural flavonoid, fisetin, on performance, redox status, chickens. The results showed that dietary fisetin supplementation improved egg production eggshell quality chickens, reduced rate, promoted cell proliferation, elevated serum estrogen progesterone levels, restored antioxidant capacity, metabolism. Furthermore, treatment increased activity enzymes by inhibiting NF-κB signaling COX-2 expression while promoting SIRT1 H2O2-induced small white follicle (SWF). Additionally, significantly enhanced anti-apoptotic capacity SWF glucose catabolism activating AKT JNK pathways. In summary, can alleviate oxidative chickens upregulating signaling. activation pathways contributes balance promotion development ovaries thereby retarding poultry production.

Language: Английский

Chicken ovarian follicular atresia: interaction network at organic, cellular, and molecular levels DOI Creative Commons
Ru Meng,

Haiping Liang,

Jiming Ruan

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(8), P. 103893 - 103893

Published: May 26, 2024

Most of follicles undergo a degenerative process called follicular atresia. This directly affects the egg production laying hens and is regulated by external internal factors. External factors primarily include nutrition environmental In atresia, are predominantly at 3 levels; organic, cellular molecular levels. At organic level, hypothalamic-pituitary-ovary (HPO) axis plays an essential role in controlling development. gonadotropins cytokines, as well estrogens, bind to their receptors activate different signaling pathways, thereby suppressing By contrast, oxidative stress induces atresia increasing ROS granulosa cell (GC) apoptosis not only factor triggering Autophagy also known give rise Epigenetics pivotal regulating gene expression processes that seem be related such apoptosis, autophagy, proliferation, steroidogenesis. Among these processes, miRNA regulation mechanism well-studied. The current review focuses on regulate levels evaluates interaction network among Additionally, this summarizes atretic follicle characteristics, vitro modeling methods, preventing hens.

Language: Английский

Citations

8
Targeting autophagy in premature ovarian failure: Therapeutic strategies from molecular pathways to clinical applications DOI

Ziwen Ding,

Genbao Shao, Mingyang Li

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123473 - 123473

Published: Feb. 1, 2025

Language: Английский

Citations

1
Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies DOI Creative Commons
Abdel Halim Harrath, Md. Ataur Rahman,

Sujay Kumar Bhajan

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1354 - 1354

Published: Aug. 14, 2024

Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.

Language: Английский

Citations

4
Study on the Mechanism of the Chinese Herbal Pair Banxia-Chenpi in Ameliorating Polycystic Ovary Syndrome Based on the CYP17A1 Gene DOI

Can Shen,

Haotian Li, Min Xiao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119503 - 119503

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nobiletin ameliorates monosodium urate-induced gouty arthritis in mice by enhancing AMPK/mTOR-mediated autophagy to inhibit NF-κB/NLRP3 inflammasome activation DOI
Zhiyong Liu,

A. Chu,

Zhi-Ming Bai

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: unknown, P. 106982 - 106982

Published: Feb. 1, 2025

Language: Английский

Citations

0
Atrophic C2C12 Myotubes Activate Inflammatory Response of Macrophages In Vitro DOI Creative Commons
Cong Wu, Yishan Tong, Jiapeng Huang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 317 - 317

Published: Feb. 20, 2025

Skeletal muscle wasting is commonly observed in aging, immobility, and chronic diseases. In pathological conditions, the impairment of skeletal immune system often occurs simultaneously. Recent studies have highlighted initiative role interactions with cells. However, impact on macrophage inflammatory responses remains poorly understood. To investigate effect atrophic myotubes response macrophages, we established two vitro models to induce myotube atrophy: one induced by D-galactose other starvation. Conditioned medium (CM) from normal were collected administered bone marrow-derived macrophages (BMDMs) mice. Subsequently, lipopolysaccharide (LPS) stimulation was applied, expression cytokines measured via RT-qPCR. Both starvation treatments reduced diameter upregulated atrophy-related gene expression. CM both augmented pro-inflammatory factors BMDMs following LPS stimulation, including Il6, Il1b, Nfkb1. Notably, starvation-induced also enhanced Il12b, Tnf, Nos2 after a not D-galactose-induced myotubes. These findings suggest that LPS-induced mediators macrophages.

Language: Английский

Citations

0
Effects of Melatonin on H2O2-Induced Oxidative Damage of the Granulosa Cells in Hen Ovarian Follicles DOI Open Access

Sheng Wang,

Yu Ou,

Sinan Cao

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 362 - 362

Published: March 22, 2025

Background: The egg-laying performance of hens is primarily regulated by ovarian follicle growth and development; these follicles are susceptible to oxidative damage caused excessive reactive oxygen species (ROS). Oxidative can lead follicular atresia impaired reproductive performance. Melatonin (MT), a known endogenous antioxidant, plays role in regulating damage, but its precise mechanisms mitigating H2O2-induced via mitophagy regulation granulosa cells remain unclear. Methods: An vitro model was established determining the optimal H2O2 concentration using CCK-8 fluorescence quantification. MT identified through quantification catalase (CAT) activity assays. protective effects against were investigated flow cytometry, Western blotting, ELISA, quantitative analysis. Results: cells, characterized P53 LC3-II upregulation LC3-I BCL-2 downregulation. for reducing cellular injury determined. co-treatment enhanced CAT, GSH, SOD activities, decreased LC3-II/LC3-I conversion, increased P62 expression. Furthermore, reduced autophagic vesicle formation restored mitochondrial membrane potential, demonstrating effect damage. Conclusions: alleviates chicken modulating antioxidant defense, autophagy, function. These findings provide newer insights our understanding regulatory underlying alleviation during development chickens.

Language: Английский

Citations

0
Utilizing Flaxseed as an Antimicrobial Alternative in Chickens: Integrative Review for Salmonella enterica and Eimeria DOI Creative Commons
William Weston, Karen H. Hales, Dale B. Hales

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(11), P. 12322 - 12342

Published: Oct. 31, 2024

This review provides an integrative framework for understanding flaxseed (

Language: Английский

Citations

0
Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic Homeostasis DOI Creative Commons

Zhaoyu Yang,

Jiaxuan Zhang,

Qiongyu Yuan

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1432 - 1432

Published: Nov. 21, 2024

Oxidative stress is a crucial factor contributing to ovarian follicular atresia and an imbalance in energy metabolism poultry, leading decreased laying performance aging hens. This study aimed investigate the effects of natural flavonoid, fisetin, on performance, redox status, chickens. The results showed that dietary fisetin supplementation improved egg production eggshell quality chickens, reduced rate, promoted cell proliferation, elevated serum estrogen progesterone levels, restored antioxidant capacity, metabolism. Furthermore, treatment increased activity enzymes by inhibiting NF-κB signaling COX-2 expression while promoting SIRT1 H2O2-induced small white follicle (SWF). Additionally, significantly enhanced anti-apoptotic capacity SWF glucose catabolism activating AKT JNK pathways. In summary, can alleviate oxidative chickens upregulating signaling. activation pathways contributes balance promotion development ovaries thereby retarding poultry production.

Language: Английский

Citations

0