Naringenin-loaded nanoparticles modulate HIF-driven oxygen-sensing pathways in lung adenocarcinoma cells

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 12, 2025

Abstract Background Hypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. It has recently been established that naringenin (NAR) its nanoparticles are chemo-preventive flavonoids in Aim Adjust HIF activity reviving oxygen-sensing enzyme while considering possible therapeutic targets. Method The bindings NAR to target proteins were examined using computational modeling techniques. Additionally, (NARNPs) synthesized characterized. Normal fibroblast cells A549 used determine cytotoxicity. Colorimetric analysis α-ketoglutarate detection for hydroxylases. Results According molecular modeling, have high affinity. PHD FIH activities significantly stimulated. Conclusion NARNPs diminish hypoxia cancer stimulating

Language: Английский

Integrated anti-inflammatory and anti-fibrosis dual drug-loaded core-shell fiber scaffolds: Diabetic wound healing and scar reduction

Journal of Material Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский