Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5951 - 5951
Published: Dec. 17, 2024
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
condition
characterized
by
immune
dysregulation,
barrier
dysfunction,
and
significant
patient
burden.
Recent
studies
have
highlighted
the
aryl
hydrocarbon
receptor
(AhR)
as
promising
therapeutic
target
for
AD
management
because
of
its
pivotal
role
in
modulating
responses
maintaining
integrity.
The
dysfunction
AhR
pathway
has
been
linked
to
pathogenesis,
emphasizing
need
therapies
that
can
restore
regulatory
functions.
Natural
products
emerged
potential
modulators
are
effective
safe
alternatives
conventional
treatments.
Compounds
such
curcumin,
resveratrol,
quercetin,
microbial
metabolites
demonstrated
ability
activate
AhR,
reduce
inflammation,
promote
function.
These
natural
agents
fewer
side
effects
enhance
compliance
compared
with
therapies,
making
them
attractive
candidates
long-term
management.
integration
targeting
provides
multifaceted
approach
alleviates
symptoms,
addresses
underlying
disease
mechanisms,
promotes
sustainable
improvements
health.
This
review
highlights
their
roles
enhancing
outcomes
through
novel
integrative
treatment
strategies.
Experimental Dermatology,
Journal Year:
2025,
Volume and Issue:
34(5)
Published: April 29, 2025
ABSTRACT
Immune‐mediated
skin
disorders
arise
from
dysfunctional
immune
responses,
instigating
inflammatory
dermatoses
and
a
reduced
quality
of
life.
The
complex
pathogenesis
likely
involves
genetic
risks,
environmental
triggers
aberrant
activation.
An
emerging
body
evidence
suggests
that
bile
acid
disturbances
may
critically
promote
pathology
in
certain
conditions.
Bile
acids
synthesised
cholesterol
regulate
nutrient
metabolism
cell
function
via
nuclear
receptors
G
protein‐coupled
(GPCRs).
Altered
profiles
receptor
expression
have
been
identified
psoriasis,
atopic
dermatitis
(AD)
autoimmune
blistering
diseases.
Disruptions
signalling
affect
the
metabolic
pathways
linked
to
these
disorders.
Targeting
components
axis
represents
promising
therapeutic
strategy.
This
review
elucidates
intricate
links
between
homeostasis
dysfunction
diseases,
synthesising
targeting
unlock
innovative
avenues.
study
compiles
clinical
experimental
data
revealing
disrupted
composition
various
immune‐mediated
dermatoses,
highlighting
significance
cutaneous
regulation.
Open Journal of Medical Psychology,
Journal Year:
2024,
Volume and Issue:
13(02), P. 25 - 38
Published: Jan. 1, 2024
This
comprehensive
review
investigates
the
significant
psychological
impact
and
profound
comorbidities
found
in
individuals
suffering
from
chronic
pruritic
dermatoses,
including
atopic
dermatitis,
urticaria,
prurigo
nodularis.
Highlighting
complex,
reciprocal
relationship
between
pruritus
psychiatric
conditions
such
as
depression,
anxiety,
sleep
disturbances,
this
paper
elucidates
of
dermatological
disorders
on
skin
addition
to
far-reaching
effects
an
individual's
well-being.
By
evaluating
efficacy
integrated
psychodermatological
interventions,
cognitive
behavioral
therapy,
mindfulness
practices,
pharmacological
treatments,
innovative
telepsychiatry
digital
health
solutions,
aims
lay
foundation
for
a
more
holistic
approach
treatment
concurrent
conditions.
Future
research
endeavors
should
delve
deeper
into
mechanistic
pruritus-psychiatry
interface,
refinement
tailored
strategies,
evaluation
long-term
patient
outcomes.
In
doing
so,
seeks
contribute
optimization
care
well-being,
underscoring
pivotal
role
addressing
both
needs
achieving
Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5951 - 5951
Published: Dec. 17, 2024
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
condition
characterized
by
immune
dysregulation,
barrier
dysfunction,
and
significant
patient
burden.
Recent
studies
have
highlighted
the
aryl
hydrocarbon
receptor
(AhR)
as
promising
therapeutic
target
for
AD
management
because
of
its
pivotal
role
in
modulating
responses
maintaining
integrity.
The
dysfunction
AhR
pathway
has
been
linked
to
pathogenesis,
emphasizing
need
therapies
that
can
restore
regulatory
functions.
Natural
products
emerged
potential
modulators
are
effective
safe
alternatives
conventional
treatments.
Compounds
such
curcumin,
resveratrol,
quercetin,
microbial
metabolites
demonstrated
ability
activate
AhR,
reduce
inflammation,
promote
function.
These
natural
agents
fewer
side
effects
enhance
compliance
compared
with
therapies,
making
them
attractive
candidates
long-term
management.
integration
targeting
provides
multifaceted
approach
alleviates
symptoms,
addresses
underlying
disease
mechanisms,
promotes
sustainable
improvements
health.
This
review
highlights
their
roles
enhancing
outcomes
through
novel
integrative
treatment
strategies.
