Stimuli-responsive smart nanomaterials for theranostics of urological cancers
Coordination Chemistry Reviews,
Journal Year:
2025,
Volume and Issue:
539, P. 216745 - 216745
Published: May 1, 2025
Language: Английский
Prebiotic Peptide Synthesis: How Did Longest Peptide Appear?
Yuling Yang,
No information about this author
Zhibiao Wang,
No information about this author
Jin Bai
No information about this author
et al.
Journal of Molecular Evolution,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
Language: Английский
Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics
Journal of Extracellular Biology,
Journal Year:
2024,
Volume and Issue:
3(11)
Published: Oct. 30, 2024
The
translation
of
pre-clinical
anti-cancer
therapies
to
regulatory
approval
has
been
promising,
but
slower
than
hoped.
While
innovative
and
effective
treatments
continue
achieve
or
seek
approval,
setbacks
are
often
attributed
a
lack
efficacy,
failure
clinical
endpoints,
dose-limiting
toxicities.
Successful
efforts
have
characterized
by
the
development
therapeutics
designed
specifically
deliver
optimal
dosing
tumour
cells
while
minimizing
off-target
toxicity.
Much
effort
devoted
rational
design
application
synthetic
nanoparticles
serve
as
targeted
therapeutic
delivery
vehicles.
Several
challenges
successful
this
modality
vehicles
include
induction
protracted
immune
response
that
results
in
their
rapid
systemic
clearance,
manufacturing
cost,
stability,
biocompatibility.
Extracellular
vesicles
(EVs)
heterogeneous
class
endogenous
biologically
produced
lipid
bilayer
mediate
intercellular
communication
carrying
bioactive
macromolecules
capable
modifying
cellular
phenotypes
local
distant
cells.
By
genetic,
chemical,
metabolic
methods,
extracellular
can
be
engineered
display
targeting
moieties
on
surface
transporting
specific
cargo
modulate
pathological
processes
following
uptake
target
cell
populations.
This
review
will
survey
types
EVs,
composition
cargoes,
strategies
employed
increase
targeting,
uptake,
release,
potential
Language: Английский
Hybrid nano-stimulator for specific amplification of oxidative stress and precise tumor treatment
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 14
Published: June 4, 2024
The
use
of
reactive
oxygen
species
(ROS)
to
target
cancer
cells
has
become
a
hot
topic
in
tumor
therapy.
Language: Английский
Spatially Variable Genes
Shantagoud Biradar,
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Chaaya Suresh,
No information about this author
Nagashri Nanjundeshwara
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et al.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 28
Published: Dec. 17, 2024
The
clinical
translation
of
spatial
transcriptomics
represents
cancer
diagnosis
and
therapy
based
on
the
role
heterogeneity
cancer-associated
fibroblasts
(CAFs)
within
tumor
microenvironment
(TME).
Recent
developments
in
have
enabled
a
detailed
characterization
organization
cellular
interactions
tumors.
data
integration,
multi-omics
approaches,
along
with
developing
standardized
protocols
is
essential
for
effective
translation.
experimental
selection
regimes
factorial
designs
reveals
novel
insights
into
biomarkers
prognostic
value
CAFs.
incorporation
optogenetics
advancements
bio-engineered
gene
circuits,
therapeutics
tissue
engineering
further
underscores
potential
to
refine
patient
stratification
improve
treatment
responsiveness.
By
integrating
workflows,
this
work
aims
advance
personalized
therapies
biology.
Language: Английский