Strategies for promoting neurovascularization in bone regeneration
Military Medical Research,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: March 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
Language: Английский
Regenerative Potential of Neural Stem/Progenitor Cells for Bone Repair
Tissue Engineering Part B Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Language: Английский
The causal relationship of inflammation-related factors with osteoporosis: A Mendelian Randomization Analysis
Experimental Gerontology,
Journal Year:
2025,
Volume and Issue:
202, P. 112715 - 112715
Published: Feb. 22, 2025
We
used
Mendelian
randomization
(MR)
approach
to
examine
whether
genetically
determined
inflammation-related
risk
factors
play
a
role
in
the
onset
of
osteoporosis
(OP)
European
population.
Genome-wide
association
studies
(GWASs)
summary
statistics
estimated
bone
mineral
density
(eBMD)
obtained
from
public
database
GEnetic
Factors
for
OSteoporosis
Consortium
(GEFOS)
including
142,487
people.
For
exposures,
we
utilized
GWAS
data
9
diseases
chronic
kidney
disease
(CKD)
(41,395
cases
and
439,303
controls),
type
2
diabetes
(T2D)
(88,427
566,778
Alzheimer's
(AD)
(71,880
cases,
383,378
controls)
major
depression
disorder
(MDD)
(9240
9519
lifestyle
behaviors
are
different
consortiums.
Inverse
variance
weighted
(IVW)
analysis
was
principal
method
this
study
random
effect
model
applied;
MR-Egger
median
were
also
performed
reliable
results.
Cochran's
Q
test
regression
detect
heterogeneity
pleiotropy
leave-one-out
find
out
there
influential
SNPs.
found
that
T2D
(IVW:
β
=
0.05,
P
0.0014),
FI
-0.22,
<
0.001),
CKD
0.02,
0.009),
ALZ
0.06,
0.005),
Coffee
consumption
0.11,
0.003)
causally
associated
with
OP
(P<0.006after
Bonferroni
correction).
Our
revealed
T2D,
FI,
CKD,
coffee
OP.
Future
interventions
targeting
above
could
provide
new
clinical
strategies
personalized
prevention
treatment
osteoporosis.
Language: Английский
Acute effects of high-intensity interval exercise plus whole-body vibration on bone turnover markers, BDNF, irisin, and neurocognitive performance in postmenopausal women
Biological Psychology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109029 - 109029
Published: April 1, 2025
Language: Английский
Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13007 - 13007
Published: Dec. 3, 2024
We
determined
the
relative
expression
levels
of
receptors
TrkA,
TrkB,
TrkC,
and
p75NTR
ligands
BDNF,
NT-3,
NGF,
NT-4
with
RNAseq
analysis
on
fetal
human
inner
ear
samples,
located
TrkB
TrkC
proteins,
quantified
BDNF
in
situ
hybridization
histological
sections
between
gestational
weeks
(GW)
9
to
19.
Spiral
ganglion
neurons
(SGNs)
satellite
glia
appear
be
main
source
synthesis
peaks
twice
at
GW10
GW15–GW17.
Tonotopical
gradients
revert
GW8
GW15
follow
a
maturation
innervation
density
gradient
SGNs.
NT-3/TrkC
follows
same
time
course
as
BDNF/TrkB.
Immunostaining
reveals
that
signaling
may
act
mainly
through
glia,
Schwann
cells,
supporting
cells
Kölliker’s
organ,
while
targets
SGNs
pillar
humans.
The
is
upregulated
when
BDNF/NT-3
downregulated,
suggesting
balancing
effect
for
sustained
activation
during
development.
mission
neurotrophins
expects
nerve
fiber
guidance,
innervation,
maturation,
trophic
effects.
data
shall
serve
provide
better
understanding
neurotrophic
regulation
action
development
assess
transferability
regenerative
therapy
from
animal
models.
Language: Английский