Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms DOI Creative Commons
Eleonora Ceneri, Alessia De Stefano, Irene Casalin

et al.

Advances in Biological Regulation, Journal Year: 2024, Volume and Issue: unknown, P. 101071 - 101071

Published: Dec. 1, 2024

Language: Английский

Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer DOI Creative Commons
Agnieszka Chytła, Stephanie Rattay, Baki Akgül

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 6, 2025

The development of metastasis is a leading cause cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus cancer cells. Elevated levels lipids, including sphingomyelin, cholesterol, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), PM, contribute to rigidity, lipid raft formation, actin polymerisation dynamics, processes drive cell invasion. This review discusses relationship between well-studied cytoplasmic phosphoinositides their lesser-known nuclear counterparts, highlighting functional role metastatic progression. Nuclear phosphoinositides, particularly PI(4,5)P2, are essential for regulating transcription factors chromatin organisation, thereby shaping gene expression patterns. We also explore PI(4,5)P2 its metabolism invasiveness metastasis, proposing model which dysregulation cytosolic and/or pool triggers malignant transformation. Understanding PI(4,5)P2-related mechanisms underlying may provide insights into potential therapeutic targets, paving way more effective therapies improved patient outcomes.

Language: Английский

Citations

0
The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5 bisphosphate and long non-coding RNA HANR DOI Creative Commons

Ana Miladinović,

Ludovica Antiga,

Tomáš Venit

et al.

Advances in Biological Regulation, Journal Year: 2024, Volume and Issue: unknown, P. 101069 - 101069

Published: Nov. 1, 2024

Language: Английский

Citations

1
Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation DOI Creative Commons

Nesrine Hifdi,

Mathilde Vaucourt,

Karim Hnia

et al.

Biology of the Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract Phosphoinositides also called Polyphosphoinositides (PPIns) are small lipid messengers with established key roles in organelle trafficking and cell signaling response to physiological environmental inputs. Besides their well‐described functions the cytoplasm, accumulating evidences pointed PPIns involvement transcription chromatin regulation. Through description of previous recent advances implication transcription, this review highlights discoveries on how modulate nuclear factors activity might impact modify gene expression. Finally, we discuss cytosolic metabolisms work jointly orchestrating transduction cascades that end nucleus

Language: Английский

Citations

1
Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms DOI Creative Commons
Eleonora Ceneri, Alessia De Stefano, Irene Casalin

et al.

Advances in Biological Regulation, Journal Year: 2024, Volume and Issue: unknown, P. 101071 - 101071

Published: Dec. 1, 2024

Language: Английский

Citations

0