Staphylococcus aureus Proteases: Orchestrators of Skin Inflammation DOI
Sabrina N. Kline, Yoshine Saito, Nathan K. Archer

et al.

DNA and Cell Biology, Journal Year: 2024, Volume and Issue: 43(10), P. 483 - 491

Published: July 3, 2024

Skin homeostasis relies on a delicate balance between host proteases and protease inhibitors along with those secreted from microbial communities, as disruption to this harmony contributes the pathogenesis of inflammatory skin disorders, including atopic dermatitis Netherton's syndrome. In addition being prominent cause soft tissue infections, gram-positive bacterium Staphylococcus aureus is key player in conditions due its array 10 proteases. Herein we review how S. augment development inflammation disorders. These mechanisms include degradation barrier integrity, immune dysregulation pruritis, impairment defenses. Delineating diverse roles has potential reveal novel therapeutic strategies, such or their cognate target, well neutralizing vaccines alleviate burden disorders patients.

Language: Английский

Staphylococcus aureus Proteases: Orchestrators of Skin Inflammation DOI
Sabrina N. Kline, Yoshine Saito, Nathan K. Archer

et al.

DNA and Cell Biology, Journal Year: 2024, Volume and Issue: 43(10), P. 483 - 491

Published: July 3, 2024

Skin homeostasis relies on a delicate balance between host proteases and protease inhibitors along with those secreted from microbial communities, as disruption to this harmony contributes the pathogenesis of inflammatory skin disorders, including atopic dermatitis Netherton's syndrome. In addition being prominent cause soft tissue infections, gram-positive bacterium Staphylococcus aureus is key player in conditions due its array 10 proteases. Herein we review how S. augment development inflammation disorders. These mechanisms include degradation barrier integrity, immune dysregulation pruritis, impairment defenses. Delineating diverse roles has potential reveal novel therapeutic strategies, such or their cognate target, well neutralizing vaccines alleviate burden disorders patients.

Language: Английский

Citations

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