Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury DOI Creative Commons
Shama Ahmad,

Waleed Nasser,

Aftab Ahmad

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Airways, alveoli and the pulmonary tissues are most vulnerable to external environment including occasional deliberate or accidental exposure highly toxic chemical gases. However, there many effective protective mechanisms that maintain integrity of preserve lung function. Alveolar macrophages form first line defense against any pathogen chemical/reactant crosses airway mucociliary barrier reaches alveolar region. Resident activated circulating monocytes infiltrate airspace contribute towards inflammatory reparative responses. Studies on response noxious stimuli rapidly emerging macrophage also being sought as therapeutic target. Here such studies have been reviewed put together for a better understanding role in general particular play pathogenesis disease caused by induced acute injury.

Language: Английский

The Multifaceted Role of Macrophages in Biology and Diseases DOI Open Access
Jan Brancewicz,

Natalia Wójcik,

Zuzanna Sarnowska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2107 - 2107

Published: Feb. 27, 2025

Macrophages are highly adaptable immune cells capable of responding dynamically to diverse environmental cues. They pivotal in maintaining homeostasis, orchestrating responses, facilitating tissue repair, and, under certain conditions, contributing disease pathogenesis. This review delves into the complex biology macrophages, highlighting their polarization states, roles autoimmune and inflammatory diseases, involvement cancer progression, potential as therapeutic targets. By understanding context-dependent functional plasticity we can better appreciate contributions health disease, paving way for innovative strategies.

Language: Английский

Citations

0
Alveolar macrophages: guardians of the alveolar lipid galaxy DOI
Isaiah Little, Stephanie Bersie, Elizabeth F. Redente

et al.

Current Opinion in Lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Purpose of review As the primary guardians at air-surface interface, functional profile alveolar macrophages (AM) is wide-ranging from establishment niche, homeostatic maintenance surfactant levels, to pathogen clearance and resolution repair processes. Alveolar lipid homeostasis disturbed in chronic lung diseases contributes disease pathogenesis through extracellular localization lumen or intracellular accumulation AM. This aims provide a focused overview state knowledge AM, their ontogeny development during health disease, how dysregulated AM lipids play key role processes, initiation resolution. Recent findings While lipid-laden are observed across broad spectrum diseases, occurrence has largely been considered consequential. advances lipidomic profiling single cell types revealed that disturbances occur early tissue-resident cells. Comparisons between inflammatory fibrotic injury models reveal specific macrophage subsets with different utilization contribute process. Summary Understanding intricate web population seeding this niche perturbed by may help leverage for new interventions.

Language: Английский

Citations

0
Lipid metabolism reprogramming in chronic obstructive pulmonary disease DOI Creative Commons
Qianqian Liang, Yide Wang, Zheng Li

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: April 7, 2025

Abstract Chronic Obstructive Pulmonary Disease (COPD) is a complex and diverse respiratory disorder, characterized by ongoing symptoms restricted airflow. The major clinical manifestations typically encompass chronic cough, sputum production, wheezing. main pathological characteristics involve infiltration of inflammatory cells, overproduction mucus, damage to the alveolar walls. underlying causes COPD are remain incompletely elucidated, thought originate from combined effect various factors. Lipids, as hydrophobic molecules, fulfill three fundamental functions: energy storage, membrane biosynthesis, signal transduction. Lipid metabolism intricately intertwined with metabolic pathways plays pivotal role in pathogenesis COPD. Delving into lipid metabolism, well particular modifications roles molecules paramount importance context This review primarily aims elucidate fatty acid onset progression Additionally, it examines potential reprogramming promising therapeutic approach, illuminating new paths for management treatment this disabling condition.

Language: Английский

Citations

0
Gene expression changes in mouse lung induced by subacute inhalation of PM 10 -rich particulate matter DOI
Jong-Uk Lee, Jisu Hong, Eun Ji Park

et al.

Inhalation Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Oct. 10, 2024

Particulate matter (PM) air pollution is associated with an increased incidence of lung diseases, but the underlying mechanisms have not been fully elucidated. In this study, a mouse model subacute inflammation was employed to investigate cellular responses and gene expression changes induced by exposure natural ambient pollution.

Language: Английский

Citations

0
Is There a Role for Bronchoscopy in Aspiration Pneumonia? DOI
Andrei Darie, Daiana Stolz

Seminars in Respiratory and Critical Care Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Aspiration represents the passage of oropharyngeal content to lower respiratory tract. The interplay between host and aspirate proprieties determines subsequent aspiration syndrome. A low pH, typical gastric aspirate, favors chemical pneumonitis, whereas an increased bacterial inoculum causes pneumonia. About a quarter patients with pneumonitis will develop superinfection during course recovery. While antibiotic therapy is indicated for pneumonia, supportive care remains cornerstone treatment in pneumonitis. However, overlapping clinical features these syndromes lead initiation antimicrobial most cases aspiration. Bronchoscopy can aid decision-making by direct airway visualization also providing access series emerging biomarkers. Invasive microbiological studies increase diagnostic yield enable tailored treatment. In conjunction stewardship programs, invasive sampling novel molecular diagnostics decrease amount inappropriate therapy. context foreign body aspiration, bronchoscopy both gold standard.

Language: Английский

Citations

0
Protocol for studying macrophage lipid crosstalk with murine tumor cells DOI Creative Commons
Daan J. Kloosterman,

Martina Farber,

Menno Boon

et al.

STAR Protocols, Journal Year: 2024, Volume and Issue: 5(4), P. 103421 - 103421

Published: Nov. 2, 2024

Language: Английский

Citations

0
Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model DOI Open Access
Martina Bonatti,

Vanessa Pitozzi,

Paola Caruso

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

ABSTRACT INTRODUCTION Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with poor prognosis. While pirfenidone nintedanib offer some benefits, they cannot cure IPF. Nintedanib inhibits various proliferative pathways has antifibrotic effects, but its molecular mechanisms impact on the transcriptome in vivo remain unclear. This study aims to evaluate nintedanib’s transcriptomic profile rat model of bleomycin-induced fibrosis. METHODOLOGY/PRINCIPAL FINDINGS Lung was induced by two intratracheal administrations bleomycin. protocol included three weeks daily oral treatments beginning seven days after first bleomycin dose. Left lungs were processed for histological evaluation using an automated quantification system Ashcroft Score, while right used RNA sequencing conduct differential expression correlation network analysis (WGCNA). WGCNA modules examined cell pathway enrichment analysis. Lipid peroxidation assessed through measurement malondialdehyde lysates. Bleomycin significant fibrotic lesions, as confirmed evaluations. reduced lesion size about 15% decreased severe scores. When compared controls, number differentially expressed genes from over 2000 barely more than 400 treatment. identified gene clusters correlated parameters, nintedanib-treated animals showing levels similar control animals. One cluster associated mesenchymal cells extracellular matrix-related pathways, line known anti-fibrotic effect nintedanib. The second cluster, involving principally macrophages, related lipid metabolism, potentially uncovering new mechanistic role modulating CONCLUSIONS/SIGNIFICANCE macrophages influenced this study, may open research directions better inquire cellular type tissue repair pathological

Language: Английский

Citations

0
Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury DOI Creative Commons
Shama Ahmad,

Waleed Nasser,

Aftab Ahmad

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Airways, alveoli and the pulmonary tissues are most vulnerable to external environment including occasional deliberate or accidental exposure highly toxic chemical gases. However, there many effective protective mechanisms that maintain integrity of preserve lung function. Alveolar macrophages form first line defense against any pathogen chemical/reactant crosses airway mucociliary barrier reaches alveolar region. Resident activated circulating monocytes infiltrate airspace contribute towards inflammatory reparative responses. Studies on response noxious stimuli rapidly emerging macrophage also being sought as therapeutic target. Here such studies have been reviewed put together for a better understanding role in general particular play pathogenesis disease caused by induced acute injury.

Language: Английский

Citations

0