Elevated serum albumin-to-creatinine ratio as a protective factor on clinical outcomes among critically ill patients with sepsis: a retrospective study

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 19, 2024

Background The aim of this study was to examine the prognostic significance serum albumin-to-creatinine ratio (ACR) in critically ill patients with sepsis. Methods This retrospective analyzed sepsis cases admitted Affiliated Hospital Jiangsu University between January 2015 and November 2023. were divided into four groups based on their ACR upon admission intensive care unit (ICU). Laboratory data collected at time ICU admission, primary outcome measure in-hospital all-cause mortality. Kaplan–Meier survival curves generated illustrate differences 30−/60-day mortality among various groups. Multivariate Cox regression models restricted cubic splines (RCS) utilized explore association patients. Subgroup analyses conducted impact other covariates relationship Results A total 1,123 eligible included study, a median 0.169. rate 33.7%, 31.9%, 30-day 28.1%. analysis demonstrated that higher had significantly lower risk (log-rank p < 0.001). Multivariable proportional hazards revealed an independent predictor death (HR: 0.454, 95% CI 0.271–0.761, = 0.003), 0.498, 0.293–0.847, 0.010), 0.399, 0.218–0.730, 0.003). For each 1-unit increase ACR, there 1.203-fold decrease during hospital stay. RCS curve illustrated non-linear negative correlation (p for =0.018), ( =0.005), =0.006). Sensitivity indicated consistent effect sizes directions different subgroups, confirming stability results. Conclusion Low levels identified as factors associated increased in-hospital, ICU, can serve significant clinical

Language: Английский

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Adrenomedullin as a New Prosperous Biomarker in Infections: Current and Future Perspectives

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6142 - 6142

Published: Oct. 15, 2024

Adrenomedullin has emerged as a promising biomarker in the field of viral diseases. Numerous studies have demonstrated its potential assessing disease severity, predicting clinical outcomes, and monitoring treatment response. (AM) is multifaceted peptide implicated vasodilation, hormone secretion, antimicrobial defense, cellular growth, angiogenesis, and, importantly, chronic pain. AM related peptides interface with cytoskeletal proteins within neuronal contexts, influencing microtubule dynamics. primarily been utilized diagnosing diseases bacterial origin, including sepsis. Nevertheless, there are reports suggesting utility this focus present study. Furthermore, adrenomedullin shown to be elevated various infections, role immune response modulation. may contribute dysfunction through mechanisms involving inflammatory responses, apoptosis, disruptions calcium homeostasis. This review aims consolidate current knowledge regarding implications diseases, elucidating diverse roles neurological pathophysiology. highlights growing importance need for further functional understand underlying involved.

Language: Английский

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Sandwich immunoassay for adrenomedullin precursor and its practical application

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 15, 2024

Adrenomedullin (ADM) is a multifaceted peptide hormone involved in numerous physiological processes, including vascular stability, vasodilation, angiogenesis, and anti-inflammatory responses. The processing of ADM results several fragments, midregional proadrenomedullin (MR-proADM), glycine-extended (ADM-Gly) bioactive (bio-ADM). MR-proADM, the stable fragment, bio-ADM, active form with short half-life, have been shown to be potent biomarkers variety pathologies. ADM-Gly, direct precursor predominant human plasma, but remains less understood least investigated. This study presents development specific immunoluminometric assay for quantification ADM-Gly offers robust one-step approach large-scale sample screening. Applied rodent it elucidates release kinetics plasma half-life ADM-Gly. Our findings confirm predominance healthy individuals its significant under pathological conditions. enables precise measurement advancing research into ADM-related pathophysiology supporting use as biomarker therapeutic target various diseases.

Language: Английский

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Adrenomedullin-mediated depressor response with visceral afferent-specific membrane depolarization in isolated nodose ganglion neurons from adult female rat

Neuropeptides, Journal Year: 2024, Volume and Issue: 108, P. 102476 - 102476

Published: Oct. 10, 2024

Language: Английский

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Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 801 - 824

Published: Nov. 11, 2024

Background. Peptidergic GPCR systems are broadly distributed in the human body and regulate numerous physiological processes by activating complex networks of intracellular biochemical events responsible for cell regulation survival. Excessive stimulation, ill-function, or blockade GPCRs produces disturbances that may cause disease should compensatory mechanisms not suffice. Methods Results. Revision updated experimental research provided an evident relationship associating peptidergic malfunction with tumor formation maintenance resulting from uncontrolled proliferation migration, colonization, inhibition apoptosis altered metabolism, increased angiogenesis tumoral tissues. Conclusion. Determination implication peptide signaling specific neoplasia is crucial to designing tailored pharmacological treatments counteract dismantle origin circuitry causing cellular disruption. In some cases, particular ligands these receptors serve as concomitant aid other physical approaches eradicate neoplasias.

Language: Английский

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