Cited by Combination Therapy of Curcumin and Cisplatin Encapsulated in Niosome Nanoparticles for Enhanced Oral Cancer Treatment

Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) DOI

Judit Bóvári‐Biri,

Judith A Miskei,

Zsanett Kövér

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 145 - 145

Published: Jan. 20, 2025

Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds shown promise in addressing these challenges, regenerating this region remains complex due to its irregular shape, intricate structure, differing cellular origins compared other bones the human body. Moreover, significant variable mechanical loads placed maxillofacial add further complexity, especially cases of difficult-to-treat medical conditions. This review provides brief overview medication-related osteonecrosis jaw (MRONJ), highlighting medication-induced adverse reactions associated clinical challenges treating condition. The purpose manuscript is emphasize role biotechnology tissue engineering technologies therapy. By using scaffold materials biofactors combination with autologous cells, innovative solutions are explored for repair damaged bones. ongoing search effective that address improve vitro preparation subsequent regeneration critical. primary spotlight current research trends novel approaches area.

Language: Английский

Citations

Polymer-Based Scaffolds as an Implantable Material in Regenerative Dentistry: A Review DOI

Ľuboš Leško,

Petra Jungová, Martina Culenova

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 80 - 80

Published: Feb. 24, 2025

Polymer-based scaffolds have emerged as transformative materials in regenerative dentistry, enabling the restoration and replacement of dental tissues through tissue engineering approaches. These scaffolds, derived from natural synthetic polymers, mimic extracellular matrix to promote cellular attachment, proliferation, differentiation. Natural polymers such collagen, chitosan, alginate offer biocompatibility bioactivity, while alternatives like polylactic acid (PLA) polycaprolactone (PCL) provide tunable mechanical properties degradation rates. Recent advancements highlight integration bioactive molecules nanotechnology enhance potential these materials. Furthermore, developing hybrid combining addresses strength challenges, paving way for patient-specific treatments. Innovations 3D bioprinting stimuli-responsive biomaterials are expected refine scaffold design further, improving therapeutic precision clinical outcomes. This review underscores critical role polymer-based advancing focusing on their applications, advantages, limitations.

Language: Английский

Citations

An experimental study of the effect of a new bone plastic material based on poly-3-hydroxybutyrate and simvastatin on bone formation processes. DOI

Karina M. Salekh, А. В. Волков, А.А. Мураев

et al.

Russian Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

BACKGROUND: Given the increasing number of patients with alveolar bone atrophy and jaw defects following trauma, relevance developing new materials osteoinductive properties remains high, highlighting importance research in field tissue engineering. AIMS: To investigate potential a novel substitution material based on poly-3-hydroxybutyrate enriched simvastatin an vivo experiment sheep. MATERIALS AND METHODS: A single-center, prospective, comparative study was conducted involving 24 healthy sheep aged 18 to months weighing 65 70 kg. The sample formed strict inclusion exclusion criteria, ensuring group homogeneity. Surgeries were performed under general local anesthesia using external approach maxillary sinus, where window created for implantation material. In first group, osteoplastic form granules containing used, while second received similar without simvastatin. outcome manifestation morphological signs osteogenesis induction morphometric evaluation structural parameters tissue. RESULTS: assessment results at 3 6 after At months, Group 1, found moderate connective multiple foci active around 2, predominated implanted material, isolated osteogenesis. amount decreased, persisted, mature lamellar predominated. Histomorphometric data showed that volume newly 34.5% 63.4% respectively, which significantly exceeded control (21.4% 36.8%, respectively). CONCLUSIONS: confirmed saturation made from polylactic acid increases However, questions regarding long-term effects use require further investigation.

Language: Английский

Citations

The Intersection of Biomaterials and Stem Cells in Tissue Repair DOI

Mallikarjun Goni,

Keshav Shenoy S,

Prasanna Baindoor

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Potential Applications of Calcium Pyrophosphate for Bone Regeneration: A Systematic Review DOI