Toward an animal model of Progressive Supranuclear Palsy DOI Creative Commons

Priyanka Singh,

Syeda Hania Qamar, Naomi P. Visanji

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 3, 2024

Progressive Supranuclear Palsy (PSP) is a rare and fatal neurodegenerative tauopathy which, with rapid clinical progression coupled to strong degree of clinico-pathologic correlation, has been suggested be "frontrunner" in translational development for proteinopathies. Elegant studies animals have contributed greatly our understanding disease pathogenesis PSP. However, presently no animal model replicates the key anatomical cytopathologic hallmarks, spatiotemporal spread pathology, progressive neurodegeneration, or locomotor cognitive symptoms that characterize Current models therefore likely fail recapitulate mechanisms underly pathological PSP, impeding their value. Here we review what learned about PSP from work date, examine gaps modeling discuss strategies refined will improve provide critical platform testing novel therapeutics this devastating disease.

Language: Английский

Astrocyte and oligodendrocyte pathology in Alzheimer's disease DOI Creative Commons

Rania Ziar,

Paul J. Tesar, Benjamin L.L. Clayton

et al.

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00540 - e00540

Published: Feb. 1, 2025

Astrocytes and oligodendrocytes, once considered passive support cells, are now recognized as active participants in the pathogenesis of Alzheimer's disease. Emerging evidence highlights critical role that these glial cells play pathological features Alzheimer's, including neuroinflammation, excitotoxicity, synaptic dysfunction, myelin degeneration, which contribute to neurodegeneration cognitive decline. Here, we review current understanding astrocyte oligodendrocyte pathology disease highlight research supports therapeutic potential modulating functions treat

Language: Английский

Citations

0
Toward an animal model of Progressive Supranuclear Palsy DOI Creative Commons

Priyanka Singh,

Syeda Hania Qamar, Naomi P. Visanji

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 3, 2024

Progressive Supranuclear Palsy (PSP) is a rare and fatal neurodegenerative tauopathy which, with rapid clinical progression coupled to strong degree of clinico-pathologic correlation, has been suggested be "frontrunner" in translational development for proteinopathies. Elegant studies animals have contributed greatly our understanding disease pathogenesis PSP. However, presently no animal model replicates the key anatomical cytopathologic hallmarks, spatiotemporal spread pathology, progressive neurodegeneration, or locomotor cognitive symptoms that characterize Current models therefore likely fail recapitulate mechanisms underly pathological PSP, impeding their value. Here we review what learned about PSP from work date, examine gaps modeling discuss strategies refined will improve provide critical platform testing novel therapeutics this devastating disease.

Language: Английский

Citations

0