Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy DOI Creative Commons
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Dec. 5, 2024

Copper (Cu) is essential for brain development and function, yet its overload induces neuronal damage contributes to neurodegeneration other neurological disorders. Multiple studies demonstrated that Cu neurotoxicity associated with mitochondrial dysfunction, routinely assessed by reduction of membrane potential. Nonetheless, the role alterations dynamics in dysfunction induced exposure still debatable. Therefore, objective present narrative review was discuss Cu-induced special emphasis on influence fusion fission, as well clearance mitophagy. Existing data demonstrate that, addition electron transport chain inhibition, damage, reactive oxygen species (ROS) overproduction, overexposure inhibits down-regulation Opa1, Mfn1, Mfn2 expression, while promoting fission through up-regulation Drp1. It has been also PINK1/Parkin-dependent mitophagy cells, considered a compensatory response dysfunction. However, long-term high-dose impairs mitophagy, resulting accumulation dysfunctional mitochondria. inhibition biogenesis due PGC-1α further aggravates brain. Studies from non-brain cells corroborate these findings, offering additional evidence dysregulation may be involved Finally, cuproptosis proteotoxic stress, contribute pathogenesis certain diseases. Based it assumed mitoprotective agents, specifically targeting mechanisms quality control, would useful prevention neurotoxic effects overload.

Language: Английский

Neuroinflammation and neurodegeneration in Huntington’s disease: genetic hallmarks, role of metals and organophosphates DOI

Omkar Kumar Kunwar,

Shamsher Singh

Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 17, 2025

Language: Английский

Citations

2
Neurotoxic chemistry: Unraveling the chemical mechanisms connecting environmental toxin exposure to neurological disorders DOI Creative Commons

Harshit Gouri,

Gaurav Bhalla

Journal of Integrated Science and Technology, Journal Year: 2025, Volume and Issue: 13(3)

Published: Jan. 7, 2025

The environmental pollution poses a serious global health risk, contributing to high morbidity and mortality rates. Neurological disorders, such as Alzheimer's, Parkinson's, Schizophrenia, ALS, Huntington's disease, are increasingly prevalent characterized by both structural functional abnormalities in neurons of the brain spinal cord. Understanding neuro-impact toxins is crucial for developing effective prevention intervention strategies. This review article investigates complex interactions between neurological health, focusing on their role development progression neurodegenerative neuropsychiatric disorders. Key mechanisms include oxidative stress, mitochondrial dysfunction, and, disruption neurotransmitter systems. It highlights pathways through which these exert effects, presents epidemiological evidence linking toxin exposure discusses potential public implications. By elucidating connections, paper aims enhance understanding determinants health.

Language: Английский

Citations

0
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Jan. 27, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

Citations

0
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Feb. 18, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

Citations

0
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: April 24, 2025

Heavy metal contamination has gradually become a highly significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These seep into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing very much important insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

Citations

0
Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy DOI Creative Commons
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Dec. 5, 2024

Copper (Cu) is essential for brain development and function, yet its overload induces neuronal damage contributes to neurodegeneration other neurological disorders. Multiple studies demonstrated that Cu neurotoxicity associated with mitochondrial dysfunction, routinely assessed by reduction of membrane potential. Nonetheless, the role alterations dynamics in dysfunction induced exposure still debatable. Therefore, objective present narrative review was discuss Cu-induced special emphasis on influence fusion fission, as well clearance mitophagy. Existing data demonstrate that, addition electron transport chain inhibition, damage, reactive oxygen species (ROS) overproduction, overexposure inhibits down-regulation Opa1, Mfn1, Mfn2 expression, while promoting fission through up-regulation Drp1. It has been also PINK1/Parkin-dependent mitophagy cells, considered a compensatory response dysfunction. However, long-term high-dose impairs mitophagy, resulting accumulation dysfunctional mitochondria. inhibition biogenesis due PGC-1α further aggravates brain. Studies from non-brain cells corroborate these findings, offering additional evidence dysregulation may be involved Finally, cuproptosis proteotoxic stress, contribute pathogenesis certain diseases. Based it assumed mitoprotective agents, specifically targeting mechanisms quality control, would useful prevention neurotoxic effects overload.

Language: Английский

Citations

2