The ARK2N (C18ORF25) Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status DOI Creative Commons

Rukiye Çığırtaş,

Celal Bulğay, Hasan Hüseyin Kazan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 684 - 684

Published: Dec. 5, 2024

Background: Data on the genetic factors contributing to inter-individual variability in muscle fiber size are limited. Recent research has demonstrated that mice lacking Arkadia (RNF111) N-terminal-like PKA signaling regulator 2N (Ark2n; also known as C18orf25) gene exhibit reduced size, contraction force, and exercise capacity, along with defects calcium handling within fast-twitch fibers. However, role of ARK2N human physiology, particularly athletic populations, remains poorly understood. The aim this study was threefold: (a) compare expression between power endurance athletes; (b) analyze relationship composition; (c) investigate association functional variant gene, sport-related phenotypes. Results: We found significantly higher athletes compared (p = 0.042) positively associated proportion oxidative (type IIA) fibers untrained subjects 0.017, adjusted for age sex). Additionally, we observed rs6507691 T allele, which predicts high 3.8 × 10−12), a greater cross-sectional area strength 0.015) over-represented world-class (38.6%; OR 2.2, p 0.023) wrestlers (33.8%; 1.8, 0.044) controls (22.0%). Conclusions: In conclusion, appears be specific myofibers, its being strength-athlete status.

Language: Английский

Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review DOI Open Access
Nikolaos Theodorakis, Magdalini Kreouzi,

Apostolis Pappas

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13438 - 13438

Published: Dec. 15, 2024

The global rise in obesity underscores the need for effective weight management strategies that address individual metabolic and hormonal variability, moving beyond simplistic “calories in, calories out” model. Body types—ectomorph, mesomorph, endomorph—provide a framework understanding differences fat storage, muscle development, energy expenditure, as each type responds uniquely to caloric intake exercise. Variability outcomes is influenced by factors such genetic polymorphisms epigenetic changes signaling pathways processes, well lifestyle factors, including nutrition, exercise, sleep, stress. These impact magnitude of lipogenesis myofibrillar protein synthesis during overfeeding, extent lipolysis proteolysis restriction, through complex mechanisms involve resting rate, pathways, profiles. Precision approaches, nutrigenomics, indirect calorimetry, artificial-intelligence-based strategies, can potentially leverage these insights create individualized aligned with person’s unique profile. By addressing personalized precision nutrition offers promising pathway sustainable outcomes. main objective this review examine adaptations driving variability explore how challenges strategies.

Language: Английский

Citations

6
BDNF coexpresses with MTOR and is associated with muscle fiber size, lean mass and power-related traits DOI Creative Commons
Celal Bulğay, Erdal Zorba, Hasan Hüseyin Kazan

et al.

European Journal of Applied Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Purpose Recent research suggests a link between brain-derived neurotrophic factor (BDNF) and the mTOR signaling pathway, key regulator of protein synthesis muscle growth. However, it remains unclear whether BDNF influences growth power performance. Our study aimed to investigate relationship expression MTOR genes in human skeletal examine association genetically predicted higher gene fiber size, lean mass, performance, athlete status. Methods The involved 456,382 subjects, including 285 athletes, 112 physically active individuals with composition data, 291 sedentary 5451 controls, 450,243 UK Biobank participants. was evaluated using immunohistochemistry, while analysis performed RNA sequencing. genotyping carried out real-time PCR or microarrays. Results We found that positively associated vastus lateralis ( p < 0.0001). Furthermore, (i.e., carriage C allele rs6265 (Val66Met) polymorphism) cross-sectional area fast-twitch fibers athletes = 0.0069), appendicular mass 2.6 × 10⁻⁷), personal best scores 0.029), status 0.0056). Conclusion demonstrates positive correlation muscle, greater enhanced

Language: Английский

Citations

0
Sporda Genetik Etki: WoS Üzerine Bibliyometrik Bir Güncelleme DOI Creative Commons
Sedat KAHYA

Herkes için Spor ve Rekreasyon Dergisi, Journal Year: 2025, Volume and Issue: 7(1), P. 13 - 25

Published: March 5, 2025

Sporda genetik etki, İGP (İnsan Genom Projesi)’nin tamamlanmasıyla büyük bir öneme sahip olmuştur. Spora özgü kuvvet, sürat, dayanıklılık becerileri ile yaralanma hassasiyeti gibi olguları belirlemede genetiğin anahtar role olduğu ve sporcu olabilmenin % 66 oranında özelliklerle açıklanan durum bilinmektedir. Bu sebeple, spor genomiği ilgili GWAS (Genome-Wide Associated Study) Athlome Project Consortium çalışmalar yapılmaya başlamıştır. Literatürde gen ilişkisine yönelik birçok çalışma bulunmasına rağmen, bu çalışmaların kapsamlı şekilde değerlendirilmesindeki eksiklikler dikkat çekicidir. amaçla, WoS veri tabanında bulunan makalelerin VOSwiever programı aracılığıyla bibliyometrik olarak görselleştirilmesi amacıyla yapılmıştır. Çalışmada, yer alan 316 makale incelenmiştir. 1.6.20 kullanılarak elde edilen veriler, analiz edilmiştir. Çalışmadan bulgulara göre, yapılan artış eğiliminde tespit alana araştırmalara verilen mali desteklerin, artışın temel sebebi olabileceği düşünülmektedir. Amerika Birleşik Devletlerinin durumu en iyi özetleyen örnek ülke konumunda aldığı görülmüştür. Sonuç olarak, alanda çalışan bilim insanlarının desteklenmesi daha farklı akademik tabanlarının titizlikle taranması ciddi katkılar sağlayabilir.

Citations

0
Genetic Determinants of Endurance: A Narrative Review on Elite Athlete Status and Performance DOI Open Access

Barkın Bıçakçı,

Paweł Cięszczyk, Kinga Humińska‐Lisowska

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13041 - 13041

Published: Dec. 4, 2024

This narrative review explores the relationship between genetics and elite endurance athletes, summarizes current literature, highlights some novel findings, provides a physiological basis for understanding mechanistic effects of in sport. Key genetic markers include

Language: Английский

Citations

1
The ARK2N (C18ORF25) Genetic Variant Is Associated with Muscle Fiber Size and Strength Athlete Status DOI Creative Commons

Rukiye Çığırtaş,

Celal Bulğay, Hasan Hüseyin Kazan

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 684 - 684

Published: Dec. 5, 2024

Background: Data on the genetic factors contributing to inter-individual variability in muscle fiber size are limited. Recent research has demonstrated that mice lacking Arkadia (RNF111) N-terminal-like PKA signaling regulator 2N (Ark2n; also known as C18orf25) gene exhibit reduced size, contraction force, and exercise capacity, along with defects calcium handling within fast-twitch fibers. However, role of ARK2N human physiology, particularly athletic populations, remains poorly understood. The aim this study was threefold: (a) compare expression between power endurance athletes; (b) analyze relationship composition; (c) investigate association functional variant gene, sport-related phenotypes. Results: We found significantly higher athletes compared (p = 0.042) positively associated proportion oxidative (type IIA) fibers untrained subjects 0.017, adjusted for age sex). Additionally, we observed rs6507691 T allele, which predicts high 3.8 × 10−12), a greater cross-sectional area strength 0.015) over-represented world-class (38.6%; OR 2.2, p 0.023) wrestlers (33.8%; 1.8, 0.044) controls (22.0%). Conclusions: In conclusion, appears be specific myofibers, its being strength-athlete status.

Language: Английский

Citations

0