Advancements in the investigation of gut microbiota-based strategies for stroke prevention and treatment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Stroke represents a predominant cause of mortality and disability on global scale, impacting millions annually exerting considerable strain healthcare systems. The incidence stroke exhibits regional variability, with ischemic accounting for the majority occurrences. Post-stroke complications, such as cognitive impairment, motor dysfunction, recurrent stroke, profoundly affect patients’ quality life. Recent advancements have elucidated microbiota-gut-brain axis (MGBA), underscoring complex interplay between gut health brain function. Dysbiosis, characterized by an imbalance in microbiota, is significantly linked to elevated risk unfavorable outcomes. MGBA plays crucial role modulating immune function, neurotransmitter levels, metabolic byproducts, which may intensify neuroinflammation impair cerebral health. This review elucidates pathophysiology explores potential gut-targeted therapeutic strategies reduce promote recovery, including probiotics, prebiotics, pharmacological interventions, dietary modifications. However, current prevention treatment based intestinal flora still face many problems, large difference individual flora, stability efficacy, long-term safety need be considered. Further research needs strengthened its better application clinical practice.

Language: Английский

Ido1 or Ido2 Deficiency in Myeloid-Derived Cells Attenuates Tmev-Induced Ictogenesis

Published: Jan. 1, 2025

Language: Английский