Cited by Mitigating Oxidative Stress and Inflammation: The Protective Role of β-lapachone in Kidney Disease

miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis DOI

Yixuan Wang,

Houkun Zhou,

Ying Liu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

Language: Английский

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NFE2L2 and ferroptosis resistance in cancer therapy DOI

Daolin Tang, Rui Kang

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a key in the cellular defense against oxidative stress, playing crucial role cancer cell survival and resistance to therapies. This review outlines current knowledge on link between NFE2L2 ferroptosis - form of regulated death characterized by iron-dependent lipid peroxidation within cells. While activation can protect normal cells from damage, its overexpression contributes drug upregulating antioxidant defenses inhibiting ferroptosis. We delve into molecular pathways ferroptosis, highlighting involvement target genes, such

Language: Английский

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Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic adenocarcinoma DOI

Yuhang Chen, Fenglin Zhang,

Shengyuan Dai

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract This study aims to evaluate the predictive value and therapeutic significance of lactate-related genes (LRGs) in pancreatic ductal adenocarcinoma (PDAC). By analyzing PDAC data from TCGA GEO databases employing WGCNA consensus clustering, we identified two lactate subtypes with distinct gene expression profiles clinical outcomes, extracted differentially expressed genes. Functional enrichment GSEA analyses were conducted explore related pathways, a lactate-associated risk signature based on four LRGs was constructed, which demonstrated significant accuracy predicting survival. In vitro experimental results showed that MCU knockdown reduced proliferation, migration, invasion, stemness cells, confirming its role malignancy PDAC. underscores importance PDAC, providing new biomarkers targets for prognostic assessment treatment Background The metabolism lactylation proteins are believed influence tumor development through their effects microenvironment immune escape mechanisms. Nevertheless, (PDAC) has yet be fully understood. investigation sought assess implications Methods We analyzed GEO, identifying LRGs. Using delineated pathways. A lactate-linked constructed using Lasso-Cox regression, validated. experiments executed examine function cells. Results Two identified, outcomes. signature, comprising LRGs, predicted survival accuracy. vitro, cell stemness, malignancy. Conclusion Our novel target.

Language: Английский

Citations

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic DOI

Mervic D. Kagho, Katharina Schmidt, Christopher Lambert

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Migrastatic drugs targeting cell motility and suppressing invasiveness of solid tumors, have the potential to bring about a paradigm shift in treatment cancer. Cytochalasin B ( CB ) is potent migrastatic compound, but its clinical use limited by poor selectivity. Here, NQO1‐responsive prodrug, BQTML‐CB developed, synthesized three steps from cytochalasin derived Preussia similis G22. selectively activated NQO1‐positive cancer cells, releasing active . In vitro , significantly inhibits proliferation migration U‐2OS causing actin disruption cytokinesis abnormalities, while sparing NQO1‐negative B16‐F1 cells. The prodrug shows reduced effects on human neutrophils, indicating immunosuppressive activity compared Co‐culture studies reveal beneficial bystander effect, as cleaved diffused into adjacent NQO1‐deficient These findings support cancer‐targeted with selective antiproliferative properties, highlighting C7‐OH‐modified cytochalasans therapy.

Language: Английский

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Cancer‐Type‐Specific DNA Methylation Is a Source of Vulnerability in Liver Cancer Cells DOI

Kazuyuki Minowa, Mineaki Seki,

Y Nagai

et al.

Cancer Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

ABSTRACT DNA methylation, a pivotal epigenetic mechanism, plays critical role in various pathological conditions, including cancers. Notably, cancer‐type‐specific methylation can be advantageous for survival only specific environments while being disadvantageous others. To investigate the of as vulnerability cancer cells, we bioinformatically profiled genome‐wide 1165 human cell lines across 25 types. The number methylated cytosines varied significantly by organ, with exceptionally high numbers observed blood A total 73 genes were identified potential liver cancer‐specific methylation‐silenced genes, and four ASNS , NQO1 FXYD5 BCAT2, subjected to experimental further analysis. Silencing BCAT2 was found contribute cells BCAT1 inhibition gabapentin. Additionally, silencing other three also rendered vulnerable under different environmental conditions. These findings enhance our understanding biological clinical significance provide basis developing diagnostic markers cancer. (169 words).

Language: Английский

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Mitigating Oxidative Stress and Inflammation: The Protective Role of β-lapachone in Kidney Disease DOI

Haoxin Liu,

Tram N. Diep,

Liang‐Jun Yan

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 1, 2025

Language: Английский

Citations